Search Results - "Frazier, Donald E"

Neurotoxic Effects of Zoniporide: A Selective Inhibitor of the Na+/H+ Exchanger Isoform 1 by Pettersen, John C., Chouinard, Luc, Kerlin, Roy L., Groom, Simon N., Botts, Suzanne, Arezzo, Joseph C., Boucher, Mary A., Frazier, Donald E., Buchholz, Allan R.

“…Zoniporide, an inhibitor of the Na+-H+ exchanger-1, was administered by continuous intravenous infusion to rats and dogs for up to 1 month. In 1-month studies,…”
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Zoniporide: a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1) by Tracey, W Ross, Allen, Mary C, Frazier, Donald E, Fossa, Anthony A, Johnson, Celeste G, Marala, Ravi B, Knight, Delvin R, Guzman-Perez, Angel

“…The sodium-hydrogen exchanger isoform-1 (NHE-1) plays an important role in the myocardial response to ischemia-reperfusion; inhibition of this exchanger…”
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Neurotoxic Effects of Zoniporide: A Selective Inhibitor of the Na super(+)/H super(+) Exchanger Isoform 1 by Pettersen, John C, Chouinard, Luc, Kerlin, Roy L, Groom, Simon N, Botts, Suzanne, Arezzo, Joseph C, Boucher, Mary A, Frazier, Donald E, Buchholz, Allan R

“…Zoniporide, an inhibitor of the Na super(+)-H super(+) exchanger-1, was administered by continuous intravenous infusion to rats and dogs for up to 1 month. In…”
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Overexpression of the Anti-apoptotic Oncogene, bcl-2, in the Thymus Does Not Prevent Thymic Atrophy Induced by Estradiol or 2,3,7,8-Tetrachlorodibenzo-p-Dioxin by Staples, J.Erin, Fiore, Nancy C., Frazier, Donald E., Gasiewicz, Thomas A., Silverstone, Allen E.

“…Dexamethasone (Dex), estradiol (E2), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) all affect the immune system, causing immunosuppression and thymic atrophy…”
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Dexamethasone, beta-estradiol, and 2,3,7,8-tetrachlorodibenzo-p-dioxin elicit thymic atrophy through different cellular targets by Silverstone, A E, Frazier, Jr, D E, Fiore, N C, Soults, J A, Gasiewicz, T A

“…The effects of single doses of dexamethasone (DEX), beta-estradiol-17-valerate (E2), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the kinetics of thymic…”
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Pharmacokinetics/dynamics of 5c8, a monoclonal antibody to CD154 (CD40 ligand) suppression of an immune response in monkeys by Gobburu, J V, Tenhoor, C, Rogge, M C, Frazier, Jr, D E, Thomas, D, Benjamin, C, Hess, D M, Jusko, W J

“…The pharmacokinetics and pharmacodynamics (PK/PD) of chimeric (Ch5c8) and humanized (Hu5c8) 5c8, a monoclonal antibody that binds CD154 (CD40 ligand), thus…”
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2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced thymic atrophy and lymphocyte stem cell alterations by mechanisms independent of the estrogen receptor by Frazier, Jr, D E, Silverstone, A E, Gasiewicz, T A

“…2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has both agonist and antagonist effects on estrogen-mediated activities and estrogen receptor (ER) levels in…”
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The thymus does not mediate 2,3,7,8-tetrachlorodibenzo-p-dioxin-elicited alterations in bone marrow lymphocyte stem cells by Frazier, Jr, D E, Silverstone, A E, Soults, J A, Gasiewicz, T A

“…Our previous studies have shown that bone marrow lymphocyte stem cells are affected following perinatal or adult exposure to…”
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Alternate immune system targets for TCDD: lymphocyte stem cells and extrathymic T-cell development by Silverstone, A E, Frazier, Jr, D E, Gasiewicz, T A

“…We here summarize evidence that thymic atrophy induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can be mediated, at least in part, by damage to…”
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Subunit vaccine protects Macaca nemestrina (pig-tailed macaque) against simian T-cell lymphotropic virus type I challenge by DEZZUTTI, C. S, FRAZIER, D. E, HUFF, L. Y, STROMBERG, P. C, OLSEN, R. G

“…Five macaques received two vaccinations consisting of soluble human T-cell lymphotropic virus type I proteins from a cell/serum-free human T-cell lymphotropic…”
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Evaluation of murine lymphocyte membrane potential, intracellular free calcium, and interleukin-2 receptor expression upon exposure to 1,1-dimethylhydrazine by Frazier, Jr, D E, Tarr, M J, Olsen, R G

“…The effects of 1,1-dimethylhydrazine (UDMH) on several early events associated with lymphocyte activation were examined. The concentration of intracellular…”
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The effects of perfluorodecanoic acid (PFDA) on humoral, cellular, and innate immunity in Fischer 344 rats by Nelson, D L, Frazier, Jr, D E, Ericson, J E, Tarr, M J, Mathes, L E

“…The in vivo effects of perfluorodecanoic acid (PFDA) exposure on antibody production, delayed type hypersensitivity (DTH), and natural killer (NK) cell…”
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