Search Results - "Frazer, John M"

Identification of fused bicyclic heterocycles as potent and selective 5-HT2A receptor antagonists for the treatment of insomnia by Xiong, Yifeng, Ullman, Brett, Choi, Jin-Sun Karoline, Cherrier, Martin, Strah-Pleynet, Sonja, Decaire, Marc, Feichtinger, Konrad, Frazer, John M., Yoon, Woo H., Whelan, Kevin, Sanabria, Erin K., Grottick, Andrew J., Al-Shamma, Hussien, Semple, Graeme

“…A series of fused bicyclic heterocycles was identified as potent and selective 5-HT2A receptor antagonists. Optimization of the series resulted in compounds…”
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Synthesis and in vivo evaluation of phenethylpiperazine amides: selective 5-hydroxytryptamine(2A) receptor antagonists for the treatment of insomnia by Xiong, Yifeng, Ullman, Brett, Choi, Jin-Sun Karoline, Cherrier, Martin, Strah-Pleynet, Sonja, Decaire, Marc, Dosa, Peter I, Feichtinger, Konrad, Teegarden, Bradley R, Frazer, John M, Yoon, Woo H, Shan, Yun, Whelan, Kevin, Hauser, Erin K, Grottick, Andrew J, Semple, Graeme, Al-Shamma, Hussien

“…Recent developments in sleep research suggest that antagonism of the serotonin 5-HT(2A) receptor may improve sleep maintenance insomnia. We herein report the…”
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Synthesis and in Vivo Evaluation of Phenethylpiperazine Amides: Selective 5-Hydroxytryptamine2A Receptor Antagonists for the Treatment of Insomnia by Xiong, Yifeng, Ullman, Brett, Choi, Jin-Sun Karoline, Cherrier, Martin, Strah-Pleynet, Sonja, Decaire, Marc, Dosa, Peter I, Feichtinger, Konrad, Teegarden, Bradley R, Frazer, John M, Yoon, Woo H, Shan, Yun, Whelan, Kevin, Hauser, Erin K, Grottick, Andrew J, Semple, Graeme, Al-Shamma, Hussien

“…Recent developments in sleep research suggest that antagonism of the serotonin 5-HT2A receptor may improve sleep maintenance insomnia. We herein report the…”
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Discovery of 1-[3-(4-Bromo-2-methyl-2 H -pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (Nelotanserin) and Related 5-Hydroxytryptamine 2A Inverse Agonists for the Treatment of Insomnia by Teegarden, Bradley R., Li, Hongmei, Jayakumar, Honnappa, Strah-Pleynet, Sonja, Dosa, Peter I., Selaya, Susan D., Kato, Naomi, Elwell, Katie H., Davidson, Jarrod, Cheng, Karen, Saldana, Hazel, Frazer, John M., Whelan, Kevin, Foster, Jonathan, Espitia, Stephan, Webb, Robert R., Beeley, Nigel R. A., Thomsen, William, Morairty, Stephen R., Kilduff, Thomas S., Al-Shamma, Hussien A.

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Synthesis and in Vivo Evaluation of Phenethylpiperazine Amides: Selective 5-Hydroxytryptamine 2A Receptor Antagonists for the Treatment of Insomnia by Xiong, Yifeng, Ullman, Brett, Choi, Jin-Sun Karoline, Cherrier, Martin, Strah-Pleynet, Sonja, Decaire, Marc, Dosa, Peter I., Feichtinger, Konrad, Teegarden, Bradley R., Frazer, John M., Yoon, Woo H., Shan, Yun, Whelan, Kevin, Hauser, Erin K., Grottick, Andrew J., Semple, Graeme, Al-Shamma, Hussien

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Discovery of 1-[3-(4-Bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea (Nelotanserin) and Related 5-Hydroxytryptamine2A Inverse Agonists for the Treatment of Insomnia by Teegarden, Bradley R, Li, Hongmei, Jayakumar, Honnappa, Strah-Pleynet, Sonja, Dosa, Peter I, Selaya, Susan D, Kato, Naomi, Elwell, Katie H, Davidson, Jarrod, Cheng, Karen, Saldana, Hazel, Frazer, John M, Whelan, Kevin, Foster, Jonathan, Espitia, Stephan, Webb, Robert R, Beeley, Nigel R. A, Thomsen, William, Morairty, Stephen R, Kilduff, Thomas S, Al-Shamma, Hussien A

“…Insomnia affects a growing portion of the adult population in the U.S. Most current therapeutic approaches to insomnia primarily address sleep onset latency…”
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Identification of fused bicyclic heterocycles as potent and selective 5-HT(2A) receptor antagonists for the treatment of insomnia by Xiong, Yifeng, Ullman, Brett, Choi, Jin-Sun Karoline, Cherrier, Martin, Strah-Pleynet, Sonja, Decaire, Marc, Feichtinger, Konrad, Frazer, John M, Yoon, Woo H, Whelan, Kevin, Sanabria, Erin K, Grottick, Andrew J, Al-Shamma, Hussien, Semple, Graeme

“…A series of fused bicyclic heterocycles was identified as potent and selective 5-HT(2A) receptor antagonists. Optimization of the series resulted in compounds…”
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Enhanced immunogenicity of leucine enkephalin following coupling to anti-immunoglobulin and anti-CD3 antibodies by Hendrickson, T L, Wilson, G S, Frazer, J M, Liu, R S, McCormack, R T, Wolfert, R L

“…Leucine enkephalin (Leu-enk) was coupled to both T and B cell antibodies in order to investigate the possibility of enhanced immunogenicity via targeted…”
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Isoaccepting transfer ribonucleic acids in liver and brain of young and old BC3F 1 mice by Frazer, J M, Yang, W K

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Effects of detergents on the activity of alpha 2-macroglobulin-protease complexes by Finlay, T H, Kadner, S S, Nathoo, S A, Levytska, V, Frazer, J M, Galdston, M

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