Validity of the GLIM criteria for the diagnosis of malnutrition in patients with colorectal cancer: A multicenter study on the diagnostic performance of different indicators of reduced muscle mass and disease severity

Validity of the GLIM criteria for the diagnosis of malnutrition in patients with colorectal cancer: A multicenter study on the diagnostic performance of different indicators of reduced muscle mass and disease severity

•None of the GLIM combinations showed satisfactory accuracy in concurrent validity.•Low muscle mass by tomography in GLIM was associated with postoperative complications.•Low muscle mass by anthropometry and disease staging in GLIM were associated with mortality. [Display omitted] To assess the conc...

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Bibliographic Details
Published in:Nutrition (Burbank, Los Angeles County, Calif.) Vol. 119; p. 112324
Main Authors: dos Santos, Ana Luiza Soares, Santos, Bárbara Chaves, Frazão, Luísa Nascimento, Miranda, Ana Lúcia, Fayh, Ana Paula Trussardi, Silva, Flávia Moraes, Gonzalez, Maria Cristina, Correia, Maria Isabel Toulson Davisson, Souza, Nilian Carla, Anastácio, Lucilene Rezende, Maurício, Sílvia Fernandes
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-03-2024
Elsevier Limited
Subjects:
Arm
Body composition
Body mass index
Cancer
Circumferences
Colorectal cancer
Colorectal carcinoma
Complications
Criteria
Diagnosis
Disease
Etiology
Fat-free body mass
GLIM criteria
Hospitals
Indicators
Malnutrition
Mortality
Muscles
Musculoskeletal system
Nutrition assessment
Postoperative
Secondary analysis
Skeletal muscle
Surgery
Validation
Validity
Vertebrae
Brazil
Rio de Janeiro Brazil
Validation
Nutrition assessment
Malnutrition
Colorectal cancer
GLIM criteria
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Summary:•None of the GLIM combinations showed satisfactory accuracy in concurrent validity.•Low muscle mass by tomography in GLIM was associated with postoperative complications.•Low muscle mass by anthropometry and disease staging in GLIM were associated with mortality. [Display omitted] To assess the concurrent and predictive validity of different combinations of Global Leadership Initiative on Malnutrition (GLIM) criteria in patients with colorectal cancer considering different indicators of reduced muscle mass (MM) and the effects of the disease. A secondary analysis with patients with colorectal cancer. The reduced MM was assessed by arm muscle area, arm muscle circumference, calf circumference, fat-free mass index, skeletal muscle index (SMI) and skeletal muscle. Cancer diagnosis or disease staging (TNM) was considered for the etiologic criterion referred to as the effect of the disease. The other phenotypic and etiologic criteria were also evaluated, and we analyzed 13 GLIM combinations. Concurrent validity between GLIM criteria and Patient-Generated Subjective Global Assessment was evaluated. Logistic and Cox regression were used in the predictive validation. For concurrent validity (n = 208), most GLIM combinations (n = 6; 54.5%) presented a moderate agreement with Patient-Generated Subjective Global Assessment and none showed satisfactory sensitivity and specificity (>80%). Reduced MM evaluated by SMI and SMI were present in the GLIM combinations associated with postoperative complications (odds ratio, ≥2.0), independent of other phenotypic and etiologic criteria. The combinations with reduced MM considering any method and fixed phenotypic criteria and TNM were associated with mortality (hazard ratio, ≥2.0). Satisfactory concurrent validity was not verified. The GLIM diagnosis of malnutrition was associated with postoperative complications and mortality.
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ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2023.112324