Search Results - "Frayling, Tim M."

Differences in smoking associated DNA methylation patterns in South Asians and Europeans by Elliott, Hannah R, Tillin, Therese, McArdle, Wendy L, Ho, Karen, Duggirala, Aparna, Frayling, Tim M, Davey Smith, George, Hughes, Alun D, Chaturvedi, Nish, Relton, Caroline L

“…DNA methylation is strongly associated with smoking status at multiple sites across the genome. Studies have largely been restricted to European origin…”
Get full text

A Common Haplotype of the Glucokinase Gene Alters Fasting Glucose and Birth Weight: Association in Six Studies and Population-Genetics Analyses by Weedon, Michael N., Clark, Vanessa J., Qian, Yudong, Ben-Shlomo, Yoav, Timpson, Nicholas, Ebrahim, Shah, Lawlor, Debbie A., Pembrey, Marcus E., Ring, Susan, Wilkin, Terry J., Voss, Linda D., Jeffery, Alison N., Metcalf, Brad, Ferrucci, Luigi, Corsi, Anna Maria, Murray, Anna, Melzer, David, Knight, Bridget, Shields, Bev, Smith, George Davey, Hattersley, Andrew T., Di Rienzo, Anna, Frayling, Tim M.

“…Fasting glucose is associated with future risk of type 2 diabetes and ischemic heart disease and is tightly regulated despite considerable variation in…”
Get full text

Understanding the complex genetic architecture connecting rheumatoid arthritis, osteoporosis and inflammation: discovering causal pathways by Kasher, Melody, Williams, Frances M K, Freidin, Maxim B, Malkin, Ida, Cherny, Stacey S, Livshits, Gregory

“…Abstract Rheumatoid arthritis (RA) and osteoporosis (OP) are two comorbid complex inflammatory conditions with evidence of shared genetic background and causal…”
Get full text

Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity by Deshmukh, Harshal A, Madsen, Anne Lundager, Viñuela, Ana, Have, Christian Theil, Grarup, Niels, Tura, Andrea, Mahajan, Anubha, Heggie, Alison J, Koivula, Robert W, De Masi, Federico, Tsirigos, Konstantinos K, Linneberg, Allan, Drivsholm, Thomas, Pedersen, Oluf, Sørensen, Thorkild I A, Astrup, Arne, Gjesing, Anette A P, Pavo, Imre, Wood, Andrew R, Ruetten, Hartmut, Jones, Angus G, Koopman, Anitra D M, Cederberg, Henna, Rutters, Femke, Ridderstrale, Martin, Laakso, Markku, McCarthy, Mark I, Frayling, Tim M, Ferrannini, Ele, Franks, Paul W, Pearson, Ewan R, Mari, Andrea, Hansen, Torben, Walker, Mark

“…Abstract Context Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of…”
Get full text

The paraoxonase (PON1) Q192R polymorphism is not associated with poor health status or depression in the ELSA or InCHIANTI studies by Rice, Neil E, Bandinelli, Stefania, Corsi, Anna Maria, Ferrucci, Luigi, Guralnik, Jack M, Miller, Michelle A, Kumari, Meena, Murray, Anna, Frayling, Tim M, Melzer, David

“…Background The human paraoxonase (PON1) protein detoxifies certain organophosphates, and the PON1 Q192R polymorphism (rs662) affects PON1 activity. Groups with…”
Get full text

Preterm Birth Genome Project (PGP) -- validation of resources for preterm birth genome-wide studies by Pennell, Craig E, Vadillo-Ortega, Felipe, Olson, David M, Ha, Eun-Hee, Williams, Scott, Frayling, Tim M, Dolan, Siobhan, Katz, Michael, Merialdi, Mario, Menon, Ramkumar

“…We determined a series of quality control (QC) analyses to assess the usability of DNA collected and processed from different countries utilizing different DNA…”
Get more information

C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization by Timpson, N.J, Nordestgaard, B.G, Harbord, R.M, Zacho, J, Frayling, T.M, Tybjærg-Hansen, A, Smith, G. Davey

“…Context: The assignment of direction and causality within networks of observational associations is problematic outside randomized control trials, and the…”
Get full text

Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independently of obesity by Scott, Robert A, Fall, Tove, Pasko, Dorota, Barker, Adam, Sharp, Stephen J, Arriola, Larraitz, Balkau, Beverley, Barricarte, Aurelio, Barroso, Inês, Boeing, Heiner, Clavel-Chapelon, Françoise, Crowe, Francesca L, Dekker, Jacqueline M, Fagherazzi, Guy, Ferrannini, Ele, Forouhi, Nita G, Franks, Paul W, Gavrila, Diana, Giedraitis, Vilmantas, Grioni, Sara, Groop, Leif C, Kaaks, Rudolf, Key, Timothy J, Kühn, Tilman, Lotta, Luca A, Nilsson, Peter M, Overvad, Kim, Palli, Domenico, Panico, Salvatore, Quirós, J. Ramón, Rolandsson, Olov, Roswall, Nina, Sacerdote, Carlotta, Sala, Núria, Sánchez, María-José, Schulze, Matthias B, Siddiq, Afshan, Slimani, Nadia, Sluijs, Ivonne, Spijkerman, Annemieke MW, Tjonneland, Anne, Tumino, Rosario, van der A, Daphne L, Yaghootkar, Hanieh, McCarthy, Mark I, Semple, Robert K, Riboli, Elio, Walker, Mark, Ingelsson, Erik, Frayling, Tim M, Savage, David B, Langenberg, Claudia, Wareham, Nicholas J

“…We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterise their association with intermediate phenotypes, and…”
Get full text