Search Results - "Frayling, T M"

Estimating sleep parameters using an accelerometer without sleep diary by van Hees, Vincent Theodoor, Sabia, S., Jones, S. E., Wood, A. R., Anderson, K. N., Kivimäki, M., Frayling, T. M., Pack, A. I., Bucan, M., Trenell, M. I., Mazzotti, Diego R., Gehrman, P. R., Singh-Manoux, B. A., Weedon, M. N.

“…Wrist worn raw-data accelerometers are used increasingly in large-scale population research. We examined whether sleep parameters can be estimated from these…”
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C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization by Timpson, N.J, Nordestgaard, B.G, Harbord, R.M, Zacho, J, Frayling, T.M, Tybjærg-Hansen, A, Smith, G. Davey

“…Context: The assignment of direction and causality within networks of observational associations is problematic outside randomized control trials, and the…”
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Genome-wide association studies: the good, the bad and the ugly by Frayling, TM

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Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population by CHANDAK, G. R, JANIPALLI, C. S, BHASKAR, S, KULKARNI, S. R, MOHANKRISHNA, P, HATTERSLEY, A. T, FRAYLING, T. M, YAJNIK, C. S

“…India has the greatest number of diabetic subjects in any one country, but the genetic basis of type 2 diabetes mellitus in India is poorly understood. Common…”
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Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants by Southam, L, Soranzo, N, Montgomery, S. B, Frayling, T. M, McCarthy, M. I, Barroso, I, Zeggini, E

“…Aims/hypothesis According to the thrifty genotype hypothesis, the high prevalence of type 2 diabetes and obesity is a consequence of genetic variants that have…”
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genetic link between type 2 diabetes and prostate cancer by Frayling, T. M, Colhoun, H, Florez, J. C

“…Epidemiological studies suggest that men with type 2 diabetes are less likely than non-diabetic men to develop prostate cancer. The cause of this association…”
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FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians by Yajnik, C. S, Janipalli, C. S, Bhaskar, S, Kulkarni, S. R, Freathy, R. M, Prakash, S, Mani, K. R, Weedon, M. N, Kale, S. D, Deshpande, J, Krishnaveni, G. V, Veena, S. R, Fall, C. H. D, McCarthy, M. I, Frayling, T. M, Hattersley, A. T, Chandak, G. R

“…Aims and hypothesis Variants of the FTO (fat mass and obesity associated) gene are associated with obesity and type 2 diabetes in white Europeans, but these…”
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Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response by Langenberg, C, Pascoe, L, Mari, A, Tura, A, Laakso, M, Frayling, T. M, Barroso, I, Loos, R. J. F, Wareham, N. J, Walker, M

“…Aims/hypothesis We investigated whether variation in MTNR1B, which was recently identified as a common genetic determinant of fasting glucose levels in…”
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An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference by Rees, S. D., Islam, M., Hydrie, M. Z. I., Chaudhary, B., Bellary, S., Hashmi, S., O'Hare, J. P., Kumar, S., Sanghera, D. K., Chaturvedi, N., Barnett, A. H., Shera, A. S., Weedon, M. N., Basit, A., Frayling, T. M., Kelly, M. A., Jafar, T. H.

“…Diabet. Med. 28, 673–680 (2011) Aims  A common variant, rs9939609, in the FTO (fat mass and obesity) gene is associated with adiposity in Europeans, explaining…”
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A common variant of the interleukin 6 receptor ( ) gene increases IL-6r and IL-6 levels, without other inflammatory effects by Rafiq, S, Frayling, T M, Murray, A, Hurst, A, Stevens, K, Weedon, M N, Henley, W, Ferrucci, L, Bandinelli, S, Corsi, A-M, Guralnik, J M, Melzer, D

“…Interleukin-6 (IL-6) is a key inflammatory cytokine, signalling to most tissues by binding to a soluble IL-6 receptor (sIL-6r), making a complex with gp130. We…”
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Beta cell glucose sensitivity is decreased by 39% in non-diabetic individuals carrying multiple diabetes-risk alleles compared with those with no risk alleles by Pascoe, L, Frayling, T. M, Weedon, M. N, Mari, A, Tura, A, Ferrannini, E, Walker, M

“…Aims/hypothesis Novel type 2 diabetes-susceptibility loci have been identified with evidence that individually they mediate the increased diabetes risk through…”
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Genetic studies of diabetes following the advent of the genome-wide association study: where do we go from here by Frayling, T. M, McCarthy, M. I

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Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis by Islam, M., Jafar, T. H., Wood, A. R., De Silva, N. M. G., Caulfield, M., Chaturvedi, N., Frayling, T. M.

“…Aims/hypothesis Multiple genetic variants are associated with type 2 diabetes-related traits in Europeans, but their role in South Asian populations needs…”
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Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes by Rafiq, S, Melzer, D, Weedon, M. N, Lango, H, Saxena, R, Scott, L. J, Palmer, C. N. A, Morris, A. D, McCarthy, M. I, Ferrucci, L, Hattersley, A. T, Zeggini, E, Frayling, T. M

“…Aims/hypothesis There are strong associations between measures of inflammation and type 2 diabetes, but the causal directions of these associations are not…”
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Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes by ZEGGINI, E, GROVES, C. J, HATTERSLEY, A. T, MCCARTHY, M. I, PARKINSON, J. R. C, HALFORD, S, OWEN, K. R, FRAYLING, T. M, WALKER, M, HITMAN, G. A, LEVY, J. C, O'RAHILLY, S

“…The proinflammatory cytokine TNF-alpha has been implicated in the pathogenesis of insulin resistance and type 2 diabetes, and variation in the gene encoding…”
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Assessing association of common variation in the C1Q gene cluster with systemic lupus erythematosus by Rafiq, S, Frayling, T.M, Vyse, T.J, Cunninghame Graham, D.S, Eggleton, P

“…Recent studies have tested genetic variation at the C1QA, C1QB and C1QC (complement component 1, q subcomponent, A chain, complement component 1, q…”
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role for coding functional variants in HNF4A in type 2 diabetes susceptibility by Jafar-Mohammadi, B, Groves, C. J, Gjesing, A. P, Herrera, B. M, Winckler, W, Stringham, H. M, Morris, A. P, Lauritzen, T, Doney, A. S. F, Morris, A. D, Weedon, M. N, Swift, A. J, Kuusisto, J, Laakso, M, Altshuler, D, Hattersley, A. T, Collins, F. S, Boehnke, M, Hansen, T, Pedersen, O, Palmer, C. N. A, Frayling, T. M, Gloyn, A. L, McCarthy, M. I

“…Aims/hypothesis Rare mutations in the gene HNF4A, encoding the transcription factor hepatocyte nuclear factor 4α (HNF-4A), account for ~5% of cases of MODY and…”
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association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits by Webster, R. J, Warrington, N. M, Weedon, M. N, Hattersley, A. T, McCaskie, P. A, Beilby, J. P, Palmer, L. J, Frayling, T. M

“…Aims/hypothesis Common genetic variants influence plasma triacylglycerol, HDL-cholesterol (HDL-C) and glucose levels in cross-sectional studies. However, the…”
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Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes by Edghill, E. L., Khamis, A., Weedon, M. N., Walker, M., Hitman, G. A., McCarthy, M. I., Owen, K. R., Ellard, S., T Hattersley, A., Frayling, T. M.

“…Diabet. Med. 28, 681–684 (2011) Aim  Genome‐wide association studies have identified > 30 common variants associated with Type 2 diabetes (> 5% minor allele…”
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Mutations in the human Delta homologue, DLL3 , cause axial skeletal defects in spondylocostal dysostosis by Bulman, Michael P, Hattersley, Andrew T, Kusumi, Kenro, Turnpenny, Peter D, Frayling, Timothy M, Lander, Eric S, Ellard, Sian, Krumlauf, Robb, McKeown, Carole, Garrett, Christine

“…Spondylocostal dysostosis (SD, MIM 277300) is a group of vertebral malsegmentation syndromes with reduced stature resulting from axial skeletal defects. SD is…”
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