Search Results - "Fray, Emily"

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses by Bruner, Katherine M., Wang, Zheng, Simonetti, Francesco R., Bender, Alexandra M., Kwon, Kyungyoon J., Sengupta, Srona, Fray, Emily J., Beg, Subul A., Antar, Annukka A. R., Jenike, Katharine M., Bertagnolli, Lynn N., Capoferri, Adam A., Kufera, Joshua T., Timmons, Andrew, Nobles, Christopher, Gregg, John, Wada, Nikolas, Ho, Ya-Chi, Zhang, Hao, Margolick, Joseph B., Blankson, Joel N., Deeks, Steven G., Bushman, Frederic D., Siliciano, Janet D., Laird, Gregory M., Siliciano, Robert F.

“…A stable latent reservoir for HIV-1 in resting CD4 + T cells is the principal barrier to a cure 1 – 3 . Curative strategies that target the reservoir are being…”
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The latent reservoir of inducible, infectious HIV-1 does not decrease despite decades of antiretroviral therapy by McMyn, Natalie F, Varriale, Joseph, Fray, Emily J, Zitzmann, Carolin, MacLeod, Hannah, Lai, Jun, Singhal, Anushka, Moskovljevic, Milica, Garcia, Mauro A, Lopez, Brianna M, Hariharan, Vivek, Rhodehouse, Kyle, Lynn, Kenneth, Tebas, Pablo, Mounzer, Karam, Montaner, Luis J, Benko, Erika, Kovacs, Colin, Hoh, Rebecca, Simonetti, Francesco R, Laird, Gregory M, Deeks, Steven G, Ribeiro, Ruy M, Perelson, Alan S, Siliciano, Robert F, Siliciano, Janet M

“…HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy (ART). The reservoir decays slowly over the first 7 years of ART…”
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Antiretroviral therapy reveals triphasic decay of intact SIV genomes and persistence of ancestral variants by Fray, Emily J., Wu, Fengting, Simonetti, Francesco R., Zitzmann, Carolin, Sambaturu, Narmada, Molina-Paris, Carmen, Bender, Alexandra M., Liu, Po-Ting, Ventura, John D., Wiseman, Roger W., O’Connor, David H., Geleziunas, Romas, Leitner, Thomas, Ribeiro, Ruy M., Perelson, Alan S., Barouch, Dan H., Siliciano, Janet D., Siliciano, Robert F.

“…The decay kinetics of HIV-1-infected cells are critical to understand virus persistence. We evaluated the frequency of simian immunodeficiency virus…”
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Biphasic decay of intact SHIV genomes following initiation of antiretroviral therapy complicates analysis of interventions targeting the reservoir by Kumar, Mithra R, Fray, Emily J, Bender, Alexandra M, Zitzmann, Carolin, Ribeiro, Ruy M, Perelson, Alan S, Barouch, Dan H, Siliciano, Janet D, Siliciano, Robert F

“…The latent reservoir for HIV-1 in resting CD4 T cells persists despite antiretroviral therapy (ART) and precludes cure. Reservoir-targeting interventions are…”
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Simian-Human Immunodeficiency Virus SHIV.C.CH505 Persistence in ART-Suppressed Infant Macaques Is Characterized by Elevated SHIV RNA in the Gut and a High Abundance of Intact SHIV DNA in Naive CD4 + T Cells by Obregon-Perko, Veronica, Bricker, Katherine M, Mensah, Gloria, Uddin, Ferzan, Kumar, Mithra R, Fray, Emily J, Siliciano, Robert F, Schoof, Nils, Horner, Anna, Mavigner, Maud, Liang, Shan, Vanderford, Thomas, Sass, Julian, Chan, Cliburn, Berendam, Stella J, Bar, Katharine J, Shaw, George M, Silvestri, Guido, Fouda, Genevieve G, Permar, Sallie R, Chahroudi, Ann

“…Mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1) continues to cause new pediatric cases of infection through breastfeeding, a…”
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Therapeutic efficacy of combined active and passive immunization in ART-suppressed, SHIV-infected rhesus macaques by Walker-Sperling, Victoria E. K., Mercado, Noe B., Chandrashekar, Abishek, Borducchi, Erica N., Liu, Jinyan, Nkolola, Joseph P., Lewis, Mark, Murry, Jeffrey P., Yang, Yunling, Geleziunas, Romas, Robb, Merlin L., Michael, Nelson L., Pau, Maria G., Wegmann, Frank, Schuitemaker, Hanneke, Fray, Emily J., Kumar, Mithra R., Siliciano, Janet D., Siliciano, Robert F., Barouch, Dan H.

“…The latent viral reservoir is the critical barrier for developing an HIV-1 cure. Previous studies have shown that therapeutic vaccination or broadly…”
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The Landscape of Persistent Viral Genomes in ART-Treated SIV, SHIV, and HIV-2 Infections by Bender, Alexandra M., Simonetti, Francesco R., Kumar, Mithra R., Fray, Emily J., Bruner, Katherine M., Timmons, Andrew E., Tai, Katherine Y., Jenike, Katharine M., Antar, Annukka A.R., Liu, Po-Ting, Ho, Ya-Chi, Raugi, Dana N., Seydi, Moussa, Gottlieb, Geoffrey S., Okoye, Afam A., Del Prete, Gregory Q., Picker, Louis J., Mankowski, Joseph L., Lifson, Jeffrey D., Siliciano, Janet D., Laird, Greg M., Barouch, Dan H., Clements, Janice E., Siliciano, Robert F.

“…Evaluation of HIV cure strategies is complicated by defective proviruses that persist in ART-treated patients but are irrelevant to cure. Non-human primates…”
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TCR-mimic bispecific antibodies to target the HIV-1 reservoir by Sengupta, Srona, Board, Nathan L, Wu, Fengting, Moskovljevic, Milica, Douglass, Jacqueline, Zhang, Josephine, Reinhold, Bruce R, Duke-Cohan, Jonathan, Yu, Jeanna, Reed, Madison C, Tabdili, Yasmine, Azurmendi, Aitana, Fray, Emily J, Zhang, Hao, Hsiue, Emily Han-Chung, Jenike, Katharine, Ho, Ya-Chi, Gabelli, Sandra B, Kinzler, Kenneth W, Vogelstein, Bert, Zhou, Shibin, Siliciano, Janet D, Sadegh-Nasseri, Scheherazade, Reinherz, Ellis L, Siliciano, Robert F

“…HIV-1 infection is incurable due to the persistence of the virus in a latent reservoir of resting memory CD4+ T cells. “Shock-and-kill” approaches that seek to…”
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Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques by Wu, Helen L., Busman-Sahay, Kathleen, Weber, Whitney C., Waytashek, Courtney M., Boyle, Carla D., Bateman, Katherine B., Reed, Jason S., Hwang, Joseph M., Shriver-Munsch, Christine, Swanson, Tonya, Northrup, Mina, Armantrout, Kimberly, Price, Heidi, Robertson-LeVay, Mitch, Uttke, Samantha, Kumar, Mithra R., Fray, Emily J., Taylor-Brill, Sol, Bondoc, Stephen, Agnor, Rebecca, Junell, Stephanie L., Legasse, Alfred W., Moats, Cassandra, Bochart, Rachele M., Sciurba, Joseph, Bimber, Benjamin N., Sullivan, Michelle N., Dozier, Brandy, MacAllister, Rhonda P., Hobbs, Theodore R., Martin, Lauren D., Panoskaltsis-Mortari, Angela, Colgin, Lois M.A., Siliciano, Robert F., Siliciano, Janet D., Estes, Jacob D., Smedley, Jeremy V., Axthelm, Michael K., Meyers, Gabrielle, Maziarz, Richard T., Burwitz, Benjamin J., Stanton, Jeffrey J., Sacha, Jonah B.

“…Allogeneic hematopoietic stem cell transplantation (alloHSCT) from donors lacking C-C chemokine receptor 5 (CCR5Δ32/Δ32) can cure HIV, yet mechanisms remain…”
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Persistence of viral RNA in lymph nodes in ART-suppressed SIV/SHIV-infected Rhesus Macaques by Cadena, Anthony M., Ventura, John D., Abbink, Peter, Borducchi, Erica N., Tuyishime, Hubert, Mercado, Noe B., Walker-Sperling, Victoria, Siamatu, Mazuba, Liu, Po-Ting, Chandrashekar, Abishek, Nkolola, Joseph P., McMahan, Katherine, Kordana, Nicole, Hamza, Venous, Bondzie, Esther A., Fray, Emily, Kumar, Mithra, Fischinger, Stephanie, Shin, Sally A., Lewis, Mark G., Siliciano, Robert F., Alter, Galit, Barouch, Dan H.

“…The establishment of a long-lived viral reservoir is the key obstacle for achieving an HIV-1 cure. However, the anatomic, virologic, and immunologic features…”
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Assessing the impact of autologous virus neutralizing antibodies on viral rebound time in postnatally SHIV-infected ART-treated infant rhesus macaques by Mainou, Ellie, Berendam, Stella J., Obregon-Perko, Veronica, Uffman, Emilie A., Phan, Caroline T., Shaw, George M., Bar, Katharine J., Kumar, Mithra R., Fray, Emily J., Siliciano, Janet M., Siliciano, Robert F., Silvestri, Guido, Permar, Sallie R., Fouda, Genevieve G., McCarthy, Janice, Chahroudi, Ann, Conway, Jessica M., Chan, Cliburn

“…While the benefits of early antiretroviral therapy (ART) initiation in perinatally infected infants are well documented, early initiation is not always…”
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CD8+ lymphocytes do not impact SIV reservoir establishment under ART by Statzu, Maura, Jin, Wang, Fray, Emily J., Wong, Andrew Kam Ho, Kumar, Mithra R., Ferrer, Elizabeth, Docken, Steffen S., Pinkevych, Mykola, McBrien, Julia B., Fennessey, Christine M., Keele, Brandon F., Liang, Shan, Harper, Justin L., Mutascio, Simona, Franchitti, Lavinia, Wang, Hong, Cicetti, Davide, Bosinger, Steven E., Carnathan, Diane G., Vanderford, Thomas H., Margolis, David M., Garcia-Martinez, J. Victor, Chahroudi, Ann, Paiardini, Mirko, Siliciano, Janet, Davenport, Miles P., Kulpa, Deanna A., Siliciano, Robert S., Silvestri, Guido

“…Persistence of the human immunodeficiency virus type-1 (HIV-1) latent reservoir in infected individuals remains a problem despite fully suppressive…”
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Therapeutic efficacy of an Ad26/MVA vaccine with SIV gp140 protein and vesatolimod in ART-suppressed rhesus macaques by Ventura, John D., Nkolola, Joseph P., Chandrashekar, Abishek, Borducchi, Erica N., Liu, Jinyan, Mercado, Noe B., Hope, David L., Giffin, Victoria M., McMahan, Katherine, Geleziunas, Romas, Murry, Jeffrey P., Yang, Yunling, Lewis, Mark G., Pau, Maria G., Wegmann, Frank, Schuitemaker, Hanneke, Fray, Emily J., Kumar, Mithra R., Siliciano, Janet D., Siliciano, Robert F., Robb, Merlin L., Michael, Nelson L., Barouch, Dan H.

“…Developing an intervention that results in virologic control following discontinuation of antiretroviral therapy (ART) is a major objective of HIV-1 cure…”
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Binding of Calcineurin Homologous Protein Isoforms 1 and 2 for the Na/H+ Exchanger Isoform 1 Using Recombinant Fluorescent Proteins by Fray, Emily, Wallert, Mark, Provost, Joseph

“…Abstract only The sodium hydrogen exchanger isoform 1 (NHE1) is a transmembrane transport protein critical for cell motility and intracellular pH regulation…”
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HSF1 inhibition attenuates HIV-1 latency reversal mediated by several candidate LRAs In Vitro and Ex Vivo by Timmons, Andrew, Fray, Emily, Kumar, Mithra, Wu, Fengting, Dai, Weiwei, Bullen, Cynthia Korin, Kim, Peggy, Hetzel, Carrie, Yang, Chao, Beg, Subul, Lai, Jun, Pomerantz, Joel L., Yukl, Steven A., Siliciano, Janet D., Siliciano, Robert F.

“…HIV-1 latency is a major barrier to cure. Identification of small molecules that destabilize latency and allow immune clearance of infected cells could lead to…”
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Induction of durable remission by dual immunotherapy in SHIV-infected ART-suppressed macaques by Lim, So-Yon, Lee, Jina, Osuna, Christa E, Vikhe, Pratik, Schalk, Dane R, Chen, Elsa, Fray, Emily, Kumar, Mithra, Schultz-Darken, Nancy, Rakasz, Eva, Capuano, Saverio, Ladd, Ruby A, Gil, Hwi Min, Evans, David T, Jeng, Emily K, Seaman, Michael, Martin, Malcolm, Van Dorp, Christiaan, Perelson, Alan S, Wong, Hing C, Siliciano, Janet D, Siliciano, Robert, Safrit, Jeffrey T, Nixon, Douglas F, Soon-Shiong, Patrick, Nussenzweig, Michel, Whitney, James B

“…The eradication of the viral reservoir represents the major obstacle to the development of a clinical cure for established HIV-1 infection. Here, we…”
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Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected anti-retroviral therapy-suppressed macaques by Wu, Helen L., Busman-Sahay, Kathleen, Weber, Whitney C., Waytashek, Courtney M., Boyle, Carla D., Bateman, Katherine B., Reed, Jason S., Hwang, Joseph M., Shriver-Munsch, Christine, Swanson, Tonya, Northrup, Mina, Armantrout, Kimberly, Price, Heidi, Robertson-LeVay, Mitch, Uttke, Samantha, Kumar, Mithra R., Fray, Emily J., Taylor-Brill, Sol, Bondoc, Stephen, Agnor, Rebecca, Junell, Stephanie L., Legasse, Alfred W., Moats, Cassandra, Bochart, Rachele M., Sciurba, Joseph, Bimber, Benjamin N., Sullivan, Michelle N., Dozier, Brandy, MacAllister, Rhonda P., Hobbs, Theodore R., Martin, Lauren D., Panoskaltsis-Mortari, Angela, Colgin, Lois M.A., Siliciano, Robert F., Siliciano, Janet D., Estes, Jacob D., Smedley, Jeremy V., Axthelm, Michael K., Meyers, Gabrielle, Maziarz, Richard T., Burwitz, Benjamin J., Stanton, Jeffrey J., Sacha, Jonah B.

“…Allogeneic hematopoietic stem cell transplantation (alloHSCT) from donors lacking C-C chemokine receptor 5 (CCR5 Δ32/Δ32 ) can cure HIV, yet mechanisms remain…”
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In vivo and in vitro interaction of calcineurin B homologous protein isoforms 1 and 2 with the Na+ ‐ H+ exchanger isoform 1 (796.10) by Wallert, Clarice, Buchholz, Scott, Keifer, Lea, Fray, Emily, Provost, Joseph, Wallert, Mark

“…The Na+‐H+ exchanger isoform 1 (NHE1) is a key regulator of cell proliferation, migration and invasion in cells from a variety of solid tumors. The calcineurin…”
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A novel quantitative approach for measuring the reservoir of latent HIV-1 proviruses by Bruner, Katherine M., Wang, Zheng, Simonetti, Francesco R., Bender, Alexandra M., Kwon, Kyungyoon J., Sengupta, Srona, Fray, Emily J., Beg, Subul A., Antar, Annukka A. R., Jenike, Katharine M., Bertagnolli, Lynn N., Capoferri, Adam A., Kufera, Joshua T., Timmons, Andrew, Nobles, Christopher, Gregg, John, Wada, Nikolas, Ho, Ya-Chi, Zhang, Hao, Margolick, Joseph B., Blankson, Joel N., Deeks, Steven G., Bushman, Frederic D., Siliciano, Janet D., Laird, Gregory M., Siliciano, Robert F.

“…A stable latent reservoir for HIV-1 in resting CD4 + T-cells precludes cure 1 – 3 . Curative strategies targeting the reservoir are being tested 4 , 5 and…”
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