Search Results - "Frauwirth, Kenneth A."

Biochemical and functional characterization of three activated macrophage populations by Edwards, Justin P., Zhang, Xia, Frauwirth, Kenneth A., Mosser, David M.

“…We generated three populations of macrophages (Mφ) in vitro and characterized each. Classically activated Mφ (Ca‐Mφ) were primed with IFN‐γ and stimulated with…”
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CTLA-4 and PD-1 Receptors Inhibit T-Cell Activation by Distinct Mechanisms by Parry, Richard V., Chemnitz, Jens M., Frauwirth, Kenneth A., Lanfranco, Anthony R., Braunstein, Inbal, Kobayashi, Sumire V., Linsley, Peter S., Thompson, Craig B., Riley, James L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Activation and inhibition of lymphocytes by costimulation by Frauwirth, Kenneth A, Thompson, Craig B

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Induction of glucose metabolism in stimulated T lymphocytes is regulated by mitogen-activated protein kinase signaling by Marko, Aimee J, Miller, Rebecca A, Kelman, Alina, Frauwirth, Kenneth A

“…T lymphocytes play a critical role in cell-mediated immune responses. During activation, extracellular and intracellular signals alter T cell metabolism in…”
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The CD28 Signaling Pathway Regulates Glucose Metabolism by Frauwirth, Kenneth A, Riley, James L, Harris, Marian H, Parry, Richard V, Rathmell, Jeffrey C, Plas, David R, Elstrom, Rebecca L, June, Carl H, Thompson, Craig B

“…Lymphocyte activation initiates a program of cell growth, proliferation, and differentiation that increases metabolic demand. Although T cells increase glucose…”
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Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation by Carr, Erikka L, Kelman, Alina, Wu, Glendon S, Gopaul, Ravindra, Senkevitch, Emilee, Aghvanyan, Anahit, Turay, Achmed M, Frauwirth, Kenneth A

“…Activation of a naive T cell is a highly energetic event, which requires a substantial increase in nutrient metabolism. Upon stimulation, T cells increase in…”
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Regulation of T Lymphocyte Metabolism by Frauwirth, Kenneth A, Thompson, Craig B

“…Upon stimulation, lymphocytes develop from small resting cells into highly proliferative and secretory cells. Although a great deal of study has focused on the…”
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Anergic CD8+ T lymphocytes have impaired NF-κB activation with defects in p65 phosphorylation and acetylation by Clavijo, Paúl E, Frauwirth, Kenneth A

“…Because of the cytotoxic potential of CD8(+) T cells, maintenance of CD8(+) peripheral tolerance is extremely important. A major peripheral tolerance mechanism…”
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T-cell regulation by CD28 and CTLA-4 by Alegre, Maria-Luisa, Frauwirth, Kenneth A, Thompson, Craig B

“…Activation of T lymphocytes is thought to require at least two signals, one delivered by the T-cell receptor complex after antigen recognition, and one…”
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Reciprocal NFAT1 and NFAT2 Nuclear Localization in CD8+ Anergic T Cells Is Regulated by Suboptimal Calcium Signaling by Srinivasan, Mathangi, Frauwirth, Kenneth A

“…Anergy is an important mechanism of maintaining peripheral immune tolerance. T cells rendered anergic are refractory to further stimulation and are…”
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Peripheral tolerance in CD8 + T cells by Srinivasan, Mathangi, Frauwirth, Kenneth A.

“…The establishment and maintenance of T cell tolerance to self- and non-pathogenic foreign antigens is critical for immune homeostasis. Thymic deletion of…”
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The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis by Jones, Russell G, Bui, Thi, White, Carl, Madesh, Muniswamy, Krawczyk, Connie M, Lindsten, Tullia, Hawkins, Brian J, Kubek, Sara, Frauwirth, Kenneth A, Wang, Y Lynn, Conway, Stuart J, Roderick, H Llewelyn, Bootman, Martin D, Shen, Hao, Foskett, J Kevin, Thompson, Craig B

“…The Bcl-2-associated X protein (Bax) and Bcl-2-antagonist/killer (Bak) are essential regulators of lymphocyte apoptosis, but whether they play a role in viable…”
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The Proapoptotic Factors Bax and Bak Regulate T Cell Proliferation through Control of Endoplasmic Reticulum Ca2+ Homeostasis by Jones, Russell G., Bui, Thi, White, Carl, Madesh, Muniswamy, Krawczyk, Connie M., Lindsten, Tullia, Hawkins, Brian J., Kubek, Sara, Frauwirth, Kenneth A., Wang, Y. Lynn, Conway, Stuart J., Roderick, H. Llewelyn, Bootman, Martin D., Shen, Hao, Foskett, J. Kevin, Thompson, Craig B.

“…The Bcl-2-associated X protein (Bax) and Bcl-2-antagonist/killer (Bak) are essential regulators of lymphocyte apoptosis, but whether they play a role in viable…”
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In the Absence of Extrinsic Signals, Nutrient Utilization by Lymphocytes Is Insufficient to Maintain Either Cell Size or Viability by Rathmell, Jeffrey C., Heiden, Mathew G.Vander, Harris, Marian H., Frauwirth, Kenneth A., Thompson, Craig B.

“…Without receptor stimulation, cells from multicellular organisms die by apoptosis. Here we show that lymphocytes deprived of receptor stimulation undergo…”
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Thiazolidinedione activation of peroxisome proliferator-activated receptor gamma can enhance mitochondrial potential and promote cell survival by Wang, Y Lynn, Frauwirth, Kenneth A, Rangwala, Shamina M, Lazar, Mitchell A, Thompson, Craig B

“…Thiazolidinediones (TZDs) are widely used for treatment of type 2 diabetes mellitus. Peroxisome proliferator-activated receptor gamma (PPAR gamma) is the…”
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Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28- antitumor T cells by CONEJO-GARCIA, Jose R, BENENCIA, Fabian, LEVINE, Bruce, COUKOS, George, COURREGES, Maria C, GIMOTTY, Phyllis A, KHANG, Eugene, BUCKANOVICH, Ronald J, FRAUWIRTH, Kenneth A, LIN ZHANG, KATSAROS, Dionyssios, THOMPSON, Craig B

“…The role of the NKG2D immunoreceptor and its ligands in antitumor immune response is incompletely understood. Here, we report that effector immune cells…”
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CTLA-4 Is Not Required for Induction of CD8+ T Cell Anergy In Vivo by Frauwirth, Kenneth A, Alegre, Maria-Luisa, Thompson, Craig B

“…Recent studies of T cell anergy induction have produced conflicting conclusions as to the role of the negative regulatory receptor, CTLA-4. Several in vivo…”
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Induction of T Cell Anergy in the Absence of CTLA-4/B7 Interaction by Frauwirth, Kenneth A, Alegre, Maria-Luisa, Thompson, Craig B

“…Immunologic tolerance in T lymphocytes is maintained through both thymic and peripheral contributions. One peripheral tolerance mechanism is the induction of T…”
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Peripheral tolerance in CD8 super(+) T cells by Srinivasan, Mathangi, Frauwirth, Kenneth A

“…The establishment and maintenance of T cell tolerance to self- and non-pathogenic foreign antigens is critical for immune homeostasis. Thymic deletion of…”
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Reciprocal NFAT1 and NFAT2 Nuclear Localization in CD8 super(+) Anergic T Cells Is Regulated by Suboptimal Calcium Signaling by Srinivasan, Mathangi, Frauwirth, Kenneth A

“…Anergy is an important mechanism of maintaining peripheral immune tolerance. T cells rendered anergic are refractory to further stimulation and are…”
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