PIEZO2 in somatosensory neurons controls gastrointestinal transit

PIEZO2 in somatosensory neurons controls gastrointestinal transit

The gastrointestinal tract is in a state of constant motion. These movements are tightly regulated by the presence of food and help digestion by mechanically breaking down and propelling gut content. Mechanical sensing in the gut is thought to be essential for regulating motility; however, the ident...

Full description

Saved in:
Bibliographic Details
Published in:Cell Vol. 186; no. 16; pp. 3386 - 3399.e15
Main Authors: Servin-Vences, M. Rocio, Lam, Ruby M., Koolen, Alize, Wang, Yu, Saade, Dimah N., Loud, Meaghan, Kacmaz, Halil, Frausto, Suzanne, Zhang, Yunxiao, Beyder, Arthur, Marshall, Kara L., Bönnemann, Carsten G., Chesler, Alexander T., Patapoutian, Ardem
Format: Journal Article
Language:English
Published: United States Elsevier Inc 03-08-2023
Subjects:
Animals
Digestion
dorsal root ganglia
gastrointestinal tract
Gastrointestinal Transit
gut motility
gut transit
Humans
interoception
Ion Channels - metabolism
mechanosensation
Mechanotransduction, Cellular
Mice
Neurons - metabolism
Piezo2
PIEZO2 deficiency
sensory neurons
spinal innervation
spinal innervation
gastrointestinal tract
interoception
PIEZO2 deficiency
gut motility
dorsal root ganglia
Piezo2
gut transit
sensory neurons
mechanosensation
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The gastrointestinal tract is in a state of constant motion. These movements are tightly regulated by the presence of food and help digestion by mechanically breaking down and propelling gut content. Mechanical sensing in the gut is thought to be essential for regulating motility; however, the identity of the neuronal populations, the molecules involved, and the functional consequences of this sensation are unknown. Here, we show that humans lacking PIEZO2 exhibit impaired bowel sensation and motility. Piezo2 in mouse dorsal root, but not nodose ganglia is required to sense gut content, and this activity slows down food transit rates in the stomach, small intestine, and colon. Indeed, Piezo2 is directly required to detect colon distension in vivo. Our study unveils the mechanosensory mechanisms that regulate the transit of luminal contents throughout the gut, which is a critical process to ensure proper digestion, nutrient absorption, and waste removal. [Display omitted] •Individuals with PIEZO2 syndrome present impaired bowel sensation and GI dysfunction•Piezo2 in DRG neurons plays an important role in regulating gut motility•Lack of Piezo2 from sensory neurons accelerates gastric emptying and intestinal transit•DRG neurons detect colon distension via Piezo2 Piezo2 in dorsal root ganglia neurons is required to sense gut content and slow down food transit rates in the stomach, small intestine, and colon.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
M.R.S.V., A.P. and A.T.C. conceived and designed the study. M.R.S.V., R. L., A.K., Y.W., M.L., S.F., and H.K. performed experiments and analyzed data. R.M.L. performed and analyzed in vivo DRG recordings. H.K. performed and analyzed videorecorded GI transit experiments. Y.Z. performed analysis of scRNAseq from 40. M.R.S.V., A.P., and A.T.C. wrote the manuscript. All authors provided input and reviewed the manuscript.
Author contributions
ISSN:0092-8674
1097-4172
1097-4172
DOI:10.1016/j.cell.2023.07.006