Search Results - "Fraunhoffer, Nicolas Fraunhoffer"

Targeting REG3β limits pancreatic ductal adenocarcinoma progression through CTGF downregulation by Fraunhoffer, Nicolás A., Closa, Daniel, Folch-Puy, Emma, Abuelafia, Analía Meilerman, Calvo, Ezequiel Luis, Chuluyan, Eduardo, Iovanna, Juan

“…The crosstalk between the transformed tumoral cells and their microenvironment is a key aspect for pancreatic ductal adenocarcinoma (PDAC) progression. This…”
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Assembly and Function of a Bioengineered Human Liver for Transplantation Generated Solely from Induced Pluripotent Stem Cells by Takeishi, Kazuki, Collin de l’Hortet, Alexandra, Wang, Yang, Handa, Kan, Guzman-Lepe, Jorge, Matsubara, Kentaro, Morita, Kazutoyo, Jang, Sae, Haep, Nils, Florentino, Rodrigo M., Yuan, Fangchao, Fukumitsu, Ken, Tobita, Kimimasa, Sun, Wendell, Franks, Jonathan, Delgado, Evan R., Shapiro, Erik M., Fraunhoffer, Nicolas A., Duncan, Andrew W., Yagi, Hiroshi, Mashimo, Tomoji, Fox, Ira J., Soto-Gutierrez, Alejandro

“…The availability of an autologous transplantable auxiliary liver would dramatically affect the treatment of liver disease. Assembly and function in vivo of a…”
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Long-term apoptosis-related protein expression in the diabetic mouse ovary by Fraunhoffer, Nicolas A, Meilerman Abuelafia, Analía, Aquino Barrientos, Mariangel, Cimerman, Karen Veronica, Olmos, María Florencia, Chuluyan, Eduardo, Barrios, Marcela

“…Emerging evidence has shown that oocytes from diabetic ovaries exhibit delayed maturation, mitochondrial dysfunction and meiotic defects, which are related…”
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Evidencing a Pancreatic Ductal Adenocarcinoma Subpopulation Sensitive to the Proteasome Inhibitor Carfilzomib by Fraunhoffer, Nicolas A, Abuelafia, Analía Meilerman, Bigonnet, Martin, Gayet, Odile, Roques, Julie, Telle, Emmanuel, Santofimia-Castaño, Patricia, Borrello, María Teresa, Chuluyan, Eduardo, Dusetti, Nelson, Iovanna, Juan

“…Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with a survival rate less than 5%. Multiple chemotherapeutic drugs have been tested to improve…”
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Designing new targeted therapies against stress granules formation in Kras-dependent pancreatic cancer by Santofimia-Castaño, Patricia, Fraunhoffer, Nicolas Fraunhoffer, Liu, Xi, Fernandez-Bessone, Ivan, Pasca di Magliano, Marina, Audebert, Stephane, Camoin, Luc, Modesti, Mauro, Lomberk, Gwen Alyce, Urrutia, Raul, Soubeyran, Philippe, Neira, Jose Luis, Iovanna, Juan

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Development of transcriptomic tools for predicting the response to individual drug of the mFOLFIRINOX regimen in patients with metastatic pancreatic cancer by Fraunhoffer, Nicolas, Teyssedou, Carlos, Pessaux, Patrick, Bigonnet, Martin, Dusetti, Nelson, Iovanna, Juan

“…The utilization of modified FOLFIRINOX (mFFX) therapy has shown notable advancements in patient outcomes in both localized and metastatic PDAC. Nevertheless,…”
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Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition by Gajate, Consuelo, Gayet, Odile, Fraunhoffer, Nicolas A., Iovanna, Juan, Dusetti, Nelson, Mollinedo, Faustino

“…Pancreatic cancer is one of the most lethal malignancies with a poor and gloomy prognosis and the highest mortality-to-incidence ratio. Pancreatic cancer…”
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Squamousness gain defines pancreatic ductal adenocarcinoma hepatic metastases phenotype, and gemcitabine response by Fraunhoffer, Nicolas A., Abuelafia, Analia M., Teyssedou, Carlos, Chuluyan, Eduardo, Bigonnet, Martin, Palazzo, Laurent, Gayet, Odile, Nicolle, Remy, Cros, Jerome, Iovanna, Juan, Dusetti, Nelson

“…Pancreatic ductal adenocarcinoma (PDAC) is a dismal disease with a survival rate of less than 7%, mainly due to the hepatic metastatic spread. Despite the…”
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Pancreatic ductal adenocarcinoma ubiquitination profiling reveals specific prognostic and theranostic markers by El Kaoutari, Abdessamad, Fraunhoffer, Nicolas A., Audebert, Stéphane, Camoin, Luc, Berthois, Yolande, Gayet, Odile, Roques, Julie, Bigonnet, Martin, Bongrain, Claire, Ciccolini, Joseph, Iovanna, Juan L., Dusetti, Nelson J., Soubeyran, Philippe

“…Pancreatic ductal adenocarcinoma (PDAC) has been widely studied at multiomics level. However, little is known about its specific ubiquitination, a major…”
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Metabolomic profiling of pancreatic adenocarcinoma reveals key features driving clinical outcome and drug resistance by Kaoutari, Abdessamad El, Fraunhoffer, Nicolas A., Hoare, Owen, Teyssedou, Carlos, Soubeyran, Philippe, Gayet, Odile, Roques, Julie, Lomberk, Gwen, Urrutia, Raul, Dusetti, Nelson, Iovanna, Juan

“…Although significant advances have been made recently to characterize the biology of pancreatic ductal adenocarcinoma (PDAC), more efforts are needed to…”
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Dissecting the Anticancer Mechanism of Trifluoperazine on Pancreatic Ductal Adenocarcinoma by Huang, Can, Lan, Wenjun, Fraunhoffer, Nicolas, Meilerman, Analía, Iovanna, Juan, Santofimia-Castaño, Patricia

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with almost no curative chemotherapeutic treatment. Besides the development of…”
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Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors by Santofimia-Castaño, Patricia, Fraunhoffer, Nicolas, Liu, Xi, Bessone, Ivan Fernandez, di Magliano, Marina Pasca, Audebert, Stephane, Camoin, Luc, Estaras, Matias, Brenière, Manon, Modesti, Mauro, Lomberk, Gwen, Urrutia, Raul, Soubeyran, Philippe, Neira, Jose Luis, Iovanna, Juan

“…We find that NUPR1, a stress-associated intrinsically disordered protein, induced droplet formation via liquid–liquid phase separation (LLPS). NUPR1-driven…”
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Limitation and challenges in using pancreatic cancer‐derived organoids as a preclinical tool by Fraunhoffer, Nicolas A., Abuelafia, Analía Meilerman, Dusetti, Nelson, Iovanna, Juan

“…A critical point to consider PDO as promising is that it must represent the great clinical heterogeneity of PDAC as much as possible. [...]PDO has displayed…”
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DNA Methylation of PI3K/AKT Pathway-Related Genes Predicts Outcome in Patients with Pancreatic Cancer: A Comprehensive Bioinformatics-Based Study by Faleiro, Inês, Roberto, Vânia Palma, Demirkol Canli, Secil, Fraunhoffer, Nicolas A, Iovanna, Juan, Gure, Ali Osmay, Link, Wolfgang, Castelo-Branco, Pedro

“…Pancreatic cancer (PCA) is one of the most lethal malignancies worldwide with a 5-year survival rate of 9%. Despite the advances in the field, the need for an…”
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Multi-omics data integration and modeling unravels new mechanisms for pancreatic cancer and improves prognostic prediction by Fraunhoffer, Nicolas A., Abuelafia, Analía Meilerman, Bigonnet, Martin, Gayet, Odile, Roques, Julie, Nicolle, Remy, Lomberk, Gwen, Urrutia, Raul, Dusetti, Nelson, Iovanna, Juan

“…Pancreatic ductal adenocarcinoma (PDAC), has recently been found to be a heterogeneous disease, although the extension of its diversity remains to be fully…”
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Biofabrication of Autologous Human Hepatocytes for Transplantation: How Do We Get There? by Agarwal, Nandini, Popovic, Branimir, Martucci, Nicole J., Fraunhoffer, Nicolas A., Soto-Gutierrez, Alejandro

“…Directed differentiation of hepatocytes from induced pluripotent stem cells (iPSCs) holds promise as source material for treating some liver disorders. The…”
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Hormonal behavior correlates with follicular recruitment at mid-gestation in the South American plains vizcacha, Lagostomus maximus (Rodentia, Caviomorpha) by Fraunhoffer, Nicolas Alejandro, Jensen, Federico, Leopardo, Noelia, Inserra, Pablo Ignacio Felipe, Abuelafia, Analía Meilerman, Espinosa, María Beatriz, Charif, Santiago Elías, Dorfman, Verónica Berta, Vitullo, Alfredo Daniel

“…Highlights • Descriptions of hormonal profile of Lagostomus maximus through entire gestation. • Analysis of hormonal receptors in L. maximus ovary through…”
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Priming therapy by targeting enhancer-initiated pathways in patient-derived pancreatic cancer cells by Fraunhoffer, Nicolas A., Moreno Vega, Aura I., Abuelafia, Analía Meilerman, Morvan, Marie, Lebarbier, Emilie, Mary-Huard, Tristan, Zimmermann, Michael T., Lomberk, Gwen, Urrutia, Raul, Dusetti, Nelson, Blum, Yuna, Nicolle, Remy, Iovanna, Juan

“…Systems biology leveraging multi-OMICs technologies, is rapidly advancing development of precision therapies and matching patients to targeted therapies,…”
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Cellular Location of HNF4α is Linked With Terminal Liver Failure in Humans by Florentino, Rodrigo M., Fraunhoffer, Nicolas A., Morita, Kazutoyo, Takeishi, Kazuki, Ostrowska, Alina, Achreja, Abhinav, Animasahun, Olamide, Haep, Nils, Arazov, Shohrat, Agarwal, Nandini, Collin de l'Hortet, Alexandra, Guzman‐Lepe, Jorge, Tafaleng, Edgar N., Mukherjee, Amitava, Troy, Kris, Banerjee, Swati, Paranjpe, Shirish, Michalopoulos, George K., Bell, Aaron, Nagrath, Deepak, Hainer, Sarah J., Fox, Ira J., Soto‐Gutierrez, Alejandro

“…Hepatocyte nuclear factor 4 alpha (HNF4α) is a transcription factor that plays a critical role in hepatocyte function, and HNF4α‐based reprogramming corrects…”
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Identification of germ cell-specific VASA and IFITM3 proteins in human ovarian endometriosis by Fraunhoffer, Nicolas A, Meilerman Abuelafia, Analía, Stella, Inés, Galliano, Silvia, Barrios, Marcela, Vitullo, Alfredo D

“…Endometriosis is a gynaecological disorder that affects 6-10 % of female population. It is characterized by the presence of endometrial tissue outside the…”
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