Search Results - "Frauenfeld, Jens"

Direct cell extraction of membrane proteins for structure–function analysis by Drulyte, Ieva, Gutgsell, Aspen Rene, Lloris-Garcerá, Pilar, Liss, Michael, Geschwindner, Stefan, Radjainia, Mazdak, Frauenfeld, Jens, Löving, Robin

“…Membrane proteins are the largest group of therapeutic targets in a variety of disease areas and yet, they remain particularly difficult to investigate. We…”
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Cryo-EM structure of the ribosome–SecYE complex in the membrane environment by Frauenfeld, Jens, Gumbart, James, Sluis, Eli O van der, Funes, Soledad, Gartmann, Marco, Beatrix, Birgitta, Mielke, Thorsten, Berninghausen, Otto, Becker, Thomas, Schulten, Klaus, Beckmann, Roland

“…A cryo-EM structure of the bacterial ribosome–SecYEG complex in a so-called Nanodisc allows for the molecular interpretation of the SecYEG complex in its…”
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SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center by Bhushan, Shashi, Hoffmann, Thomas, Seidelt, Birgit, Frauenfeld, Jens, Mielke, Thorsten, Berninghausen, Otto, Wilson, Daniel N, Beckmann, Roland

“…As nascent polypeptide chains are synthesized, they pass through a tunnel in the large ribosomal subunit. Interaction between specific nascent chains and the…”
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DirectMX - One-Step Reconstitution of Membrane Proteins From Crude Cell Membranes Into Salipro Nanoparticles by Lloris-Garcerá, Pilar, Klinter, Stefan, Chen, Liuhong, Skynner, Michael J, Löving, Robin, Frauenfeld, Jens

“…Integral membrane proteins (IMPs) are central to many physiological processes and represent ∼60% of current drug targets. An intricate interplay with the lipid…”
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High-throughput analytical gel filtration screening of integral membrane proteins for structural studies by Löw, Christian, Moberg, Per, Quistgaard, Esben M., Hedrén, Marie, Guettou, Fatma, Frauenfeld, Jens, Haneskog, Lars, Nordlund, Pär

“…Structural studies of integral membrane proteins (IMPs) are often hampered by difficulties in producing stable homogenous samples for crystallization. To…”
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Saposin-Lipoprotein Scaffolds for Structure Determination of Membrane Transporters by Lyons, Joseph A, Bøggild, Andreas, Nissen, Poul, Frauenfeld, Jens

“…Membrane proteins depend on their natural lipid environment for function, which makes them more difficult to study in isolation. A number of approaches that…”
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Parallel Structural Evolution of Mitochondrial Ribosomes and OXPHOS Complexes by van der Sluis, Eli O, Bauerschmitt, Heike, Becker, Thomas, Mielke, Thorsten, Frauenfeld, Jens, Berninghausen, Otto, Neupert, Walter, Herrmann, Johannes M, Beckmann, Roland

“…The five macromolecular complexes that jointly mediate oxidative phosphorylation (OXPHOS) in mitochondria consist of many more subunits than those of bacteria,…”
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A saposin-lipoprotein nanoparticle system for membrane proteins by Frauenfeld, Jens, Löving, Robin, Armache, Jean-Paul, Sonnen, Andreas F-P, Guettou, Fatma, Moberg, Per, Zhu, Lin, Jegerschöld, Caroline, Flayhan, Ali, Briggs, John A G, Garoff, Henrik, Löw, Christian, Cheng, Yifan, Nordlund, Pär

“…A saposin protein–lipid nanoparticle system stabilizes diverse, fragile membrane proteins in a lipid environment for structural and functional studies. A…”
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A novel lipoprotein nanoparticle system for membrane proteins by Frauenfeld, Jens, Löving, Robin, Armache, Jean-Paul, Sonnen, Andreas, Guettou, Fatma, Moberg, Per, Zhu, Lin, Jegerschöld, Caroline, Flayhan, Ali, Briggs, John A.G., Garoff, Henrik, Löw, Christian, Cheng, Yifan, Nordlund, Pär

“…Membrane proteins are of outstanding importance in biology, drug discovery and vaccination. A common limiting factor in research and applications involving…”
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Multivalence and spot heterogeneity in microarray-based measurement of binding constants by Elbs, Martin, Hulko, Michael, Frauenfeld, Jens, Fischer, Rainer, Brock, Roland

“…Microarray technology is increasingly used for a miniaturised and parallel measurement of binding constants. In microarray experiments heterogeneous…”
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