Search Results - "Frattini, M"

PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients by FRATTINI, M, SALETTI, P, ROMAGNANI, E, MARTIN, V, MOLINARI, F, GHISLETTA, M, CAMPONOVO, A, ETIENNE, L. L, CAVALLI, F, MAZZUCCHELLI, L

“…To evaluate whether the epidermal growth factor receptor (EGFR), K-Ras and PTEN, all members of the EGFR signalling pathway, may affect the clinical response…”
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HER2 gene copy number status may influence clinical efficacy to anti-EGFR monoclonal antibodies in metastatic colorectal cancer patients by Martin, V, Landi, L, Molinari, F, Fountzilas, G, Geva, R, Riva, A, Saletti, P, De Dosso, S, Spitale, A, Tejpar, S, Kalogeras, K T, Mazzucchelli, L, Frattini, M, Cappuzzo, F

“…Background: In metastatic colorectal cancer (mCRC), KRAS is the only validated biomarker used to select patients for administration of epidermal growth factor…”
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PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients by Perrone, F., Lampis, A., Orsenigo, M., Di Bartolomeo, M., Gevorgyan, A., Losa, M., Frattini, M., Riva, C., Andreola, S., Bajetta, E., Bertario, L., Leo, E., Pierotti, M.A., Pilotti, S.

“…Background: It has been reported that KRAS mutations (and to a lesser extent KRAS mutations with the BRAF V600E mutation) negatively affect response to…”
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AKT1(E17K) in human solid tumours by Bleeker, F E, Felicioni, L, Buttitta, F, Lamba, S, Cardone, L, Rodolfo, M, Scarpa, A, Leenstra, S, Frattini, M, Barbareschi, M, Grammastro, M Del, Sciarrotta, M G, Zanon, C, Marchetti, A, Bardelli, A

“…The serine-threonine kinase AKT1 is a central player in the oncogenic pathway controlled by PI3K. Recently, a somatic mutation in AKT1 (E17K) has been detected…”
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Enhancing the taxonomic delimitation of Lippia origanoides Kunth (Verbenaceae) by analyzing volatile terpenes and molecular markers in micropropagated accessions by Frattini, Laís M., Oliveira, Arthur A., Kotsubo, Jhoão S., Gorne, Íris B., Silva, Isabel C., Freitas, Jober C. E., Resende, Cristiano F., Mezzonato-Pires, Ana C., Matos, Elyabe M., Lopes, Juliana M. L., Viccini, Lyderson F., Grazul, Richard M., Peixoto, Paulo H. P.

“…This study aimed to contribute to the accurate taxonomic delimitation of Lippia origanoides Kunth (Verbenaceae), an important native Brazilian herb with…”
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Quantitative and qualitative characterization of plasma DNA identifies primary and recurrent colorectal cancer by Frattini, M, Gallino, G, Signoroni, S, Balestra, D, Lusa, L, Battaglia, L, Sozzi, G, Bertario, L, Leo, E, Pilotti, S, Pierotti, M.A

“…Abstract Because plasma DNA may be a useful tool for cancer detection, we screened primary tumors and related multiple plasma samples at the time of surgery…”
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Differing deregulation of EGFR and downstream proteins in primary colorectal cancer and related metastatic sites may be clinically relevant by Molinari, F, Martin, V, Saletti, P, De Dosso, S, Spitale, A, Camponovo, A, Bordoni, A, Crippa, S, Mazzucchelli, L, Frattini, M

“…Cetuximab and panitumumab efficacy in metastatic colorectal cancer (mCRC) may be influenced by EGFR gene status and/or deregulation of its downstream…”
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Cadmium-transformed cells in the in vitro cell transformation assay reveal different proliferative behaviours and activated pathways by Forcella, M, Callegaro, G, Melchioretto, P, Gribaldo, L, Frattini, M, Stefanini, F M, Fusi, P, Urani, C

“…The in vitro Cell Transformation Assay (CTA) is a powerful tool for mechanistic studies of carcinogenesis. The endpoint is the classification of transformed…”
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Mutation analysis of the EGFR gene and downstream signalling pathway in histologic samples of malignant pleural mesothelioma by Mezzapelle, R, Miglio, U, Rena, O, Paganotti, A, Allegrini, S, Antona, J, Molinari, F, Frattini, M, Monga, G, Alabiso, O, Boldorini, R

“…Background: As epidermal growth factor receptor (EGFR) is involved in the pathogenesis of malignant pleural mesotheliomas (MPMs), the anti-EGFR drugs may be…”
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NATHALI‐01: A PHASE 1/2A TRIAL OF UCART20X22, AN ALLOGENEIC DUAL CAR T‐CELL THERAPY FOR PATIENTS WITH RELAPSED/REFRACTORY B‐CELL NON‐HODGKIN LYMPHOMA (NHL) by Bachy, E., Ramakrishnan, A., Thieblemont, C., Alfonso, A., Braunschweig, I., Riedell, P. A., Cartron, G., Barba, P., Gastinne, T., Simon, J. A. Perez, Solano, C., Meadows, S., LaCroce, A., Thomas, D., Poirot, C., Newhall, K. J., Lee, D. J., Frattini, M. G., Abramson, J.

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An overview of the epidermal growth factor receptor fluorescence in situ hybridisation challenge in tumour pathology by Martin, V, Mazzucchelli, L, Frattini, M

“…Epidermal growth factor receptor (EGFR) is deregulated in a variety of solid malignant tumours. Due to the availability of specific targeted therapies, the…”
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Effects of azacitidine in 93 patients with IDH1/2 mutated acute myeloid leukemia/myelodysplastic syndromes: a French retrospective multicenter study by Willekens, C., Rahme, R., Duchmann, M., Vidal, V., Saada, V., Broutin, S., Delahousse, J., Renneville, A., Marceau, A., Clappier, E., Uzunov, M., Rossignol, J., Pascal, L., Simon, L., Micol, J. B., Pasquier, F., Raffoux, E., Preudhomme, C., Quivoron, C., Itzykson, R., Penard-Lacronique, V., Paci, A., Fenaux, P., Attar, E. C., Frattini, M., Braun, T., Ades, L., De Botton, S.

“…Isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) mutations in Myeloid Neoplams (MNs) exhibit DNA hypermethylation via 2-hydroxyglutarate (2HG) over-production…”
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Prognostic and predictive value of TOPK stratified by KRAS and BRAF gene alterations in sporadic, hereditary and metastatic colorectal cancer patients by Zlobec, I, Molinari, F, Kovac, M, Bihl, M P, Altermatt, H J, Diebold, J, Frick, H, Germer, M, Horcic, M, Montani, M, Singer, G, Yurtsever, H, Zettl, A, Terracciano, L, Mazzucchelli, L, Saletti, P, Frattini, M, Heinimann, K, Lugli, A

“…Background: Our aim was to investigate the prognostic and predictive value of the oncogenic MAPKK-like protein T-cell-originated protein kinase (TOPK)…”
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MFG-E8 lactadherin regulates cyclins D1 D3 expression and enhances the tumorigenic potential of mammary epithelial cells by Carrascosa, C, Obula, R G, Missiaglia, E, Lehr, H-A, Delorenzi, M, Frattini, M, Rüegg, C, Mariotti, A

“…Milk fat globule-EGF factor 8 (MFG-E8) is a glycoprotein highly expressed in breast cancer that contributes to tumor progression through largely undefined…”
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Influence of KRAS mutations on clinical outcome in patients with curatively resected stage III colon cancer treated with adjuvant chemotherapy by De Dosso, S, Nucifora, M, Sahnane, N, Epistolio, S, Riveiro, M E, Bertolini, V, Bucci, E, Boldorini, R, Freguia, S, Frattini, M, Saletti, P

“…To profile and correlate KRAS mutations with outcome in stage III colon cancer (CC) patients who underwent adjuvant chemotherapy following curative resection…”
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2861 Prospective multicenter phase II study of the anti-EGFR (epidermal growth factor receptor) antibody panitumumab (P) in patients with platinum pre-treated, advanced head and neck squamous cell cancer (HNSCC) by Siano, M, Molinari, F, Martin, V, Mach, N, Früh, M, Crippa, S, Ghielmini, M, Frattini, M, Espeli, V

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2807 Phase II explorative trial to prospectively investigate predictive molecular biomarkers for efficacy of panitumumab (P) in platinum-pretreated head and neck squamous cell cancer (HNSCC) by Siano, M, Molinari, F, Martin, V, Mach, N, Früh, M, Meehan, B, Crippa, S, Ghielmini, M, Espeli, V, Frattini, M

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P1451: PRELIMINARY RESULTS FROM THE FLU/CY/ALEMTUZUMAB ARM OF THE PHASE I BALLI‐01 TRIAL OF UCART22, AN ANTI‐CD22 ALLOGENEIC CAR‐T CELL PRODUCT, IN PATIENTS WITH RELAPSED/REFRACTORY (R/R) CD22+ B‐CELL ALL by Jain, N., Roboz, G., Konopleva, M., Liu, H., Schiller, G., Jabbour, E., Desai, P., Whitfield, D., Haider, A., Zernovak, O., Frattini, M., Brownstein, C., Larson, R.

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Monitoring the authenticity of low-fat yogurts by an artificial neural network by da Cruz, A G, Walter, E H M, Cadena, R S, Faria, J A F, Bolini, H M A, Frattini Fileti, A M

“…The growing consumption of low- and reduced-fat dairy products demands routine control of their authenticity by health agencies. The usual analyses of fat in…”
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Laser capture microdissection is a valuable tool in the preoperative molecular screening of follicular lesions of the thyroid: an institutional experience by Bongiovanni, M., Molinari, F., Eszlinger, M., Paschke, R., Barizzi, J., Merlo, E., Giovanella, L., Fasolini, F., Cattaneo, F., Ramelli, F., Mazzucchelli, L., Frattini, M.

“…Objectives The application of molecular tests to thyroid fine needle aspiration (FNA) has been shown to be a valuable tool to better refine the pre‐operative…”
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