Cytotoxicity of halogenated benzenes and its relationship with logP

The in vitro toxicity of a series of environmentally relevant halobenzenes was tested using a Chinese hamster lung fibroblast cell line and its relationship with the logarithm of octanol/water partition coefficient (logP) was investigated. Since we wanted to study the direct biological activity of t...

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Bibliographic Details
Published in:	Toxicology in vitro Vol. 11; no. 5; pp. 673 - 677
Main Authors:	Fratello, G., Marchini, S., Zucco, F., Sapora, O., Stammati, A.
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Oxford Elsevier Ltd 01-10-1997 Elsevier Science
Subjects:	Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases cytotoxicity halobenzenes logP Medical sciences Toxicology Various organic compounds halobenzenes cytotoxicity logP Toxicity Rodentia Lipophily Partition coefficient Physicochemical properties activity relationship Halocarbon In vitro Vertebrata Mammalia Animal Established cell line Aromatic compound Hamster
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Summary:	The in vitro toxicity of a series of environmentally relevant halobenzenes was tested using a Chinese hamster lung fibroblast cell line and its relationship with the logarithm of octanol/water partition coefficient (logP) was investigated. Since we wanted to study the direct biological activity of the parent substances, we have used the V-79 cell line that does not express phase I metabolic activities. Moreover, because of the available knowledge on the substances, we decided to perform the colony-forming ability test (CFA) and to analyse the DNA damage by a cytofluorimetric assay. To identify the concentration range at which the toxic effect could be detected, a prescreen with the neutral red assay has been performed. All the substances tested were positive in the CFA, but, according to the concentration values inhibiting this activity by 50%, they can be divided into two groups of differing toxicity. The FACScan analysis shows for the majority of the halobenzenes a clear hypodiploid peak. A good correlation between values describing the concentration that inhibits CFA by 50% and logP was found, indicating that it depends on the hydrophobic properties of the compounds and that logP is a suitable descriptor.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-2 ObjectType-Feature-1 content type line 23 SourceType-Conference Papers & Proceedings-1 ObjectType-Conference-3 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2
ISSN:	0887-2333 1879-3177
DOI:	10.1016/S0887-2333(97)00086-6