Search Results - "Frassetto, Lynda A"

Effects of Alterations in Acid-Base Effects on Insulin Signaling by Frassetto, Lynda A, Masharani, Umesh

“…Insulin tightly regulates glucose levels within a narrow range through its action on muscle, adipose tissue and the liver. The activation of insulin receptors…”
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Food, Acid Supplementation and Drug Absorption – a Complicated Gastric Mix: a Randomized Control Trial by Surofchy, Dalga D., Frassetto, Lynda A., Benet, Leslie Z.

“…Purpose The purpose of this study was to determine the impact of food on gastric pH and the ability of over the counter betaine hydrochloride (BHCl) acid to…”
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Higher Renal Net Acid Excretion, but Not Higher Phosphate Excretion, during Childhood and Adolescence Associates with the Circulating Renal Tubular Injury Marker Interleukin-18 in Adulthood by Derakhshandeh-Rishehri, Seyedeh-Masomeh, Franco, Luciana Peixoto, Hua, Yifan, Herder, Christian, Kalhoff, Hermann, Frassetto, Lynda A, Wudy, Stefan A, Remer, Thomas

“…High dietary phosphorus intake (P-In) and high acid loads may adversely affect kidney function. In animal models, excessive phosphorus intake causes renal…”
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Renal Embolization-Induced Uremic Swine Model for Assessment of Next-Generation Implantable Hemodialyzers by Moyer, Jarrett, Wilson, Mark W, Sorrentino, Thomas A, Santandreu, Ana, Chen, Caressa, Hu, Dean, Kerdok, Amy, Porock, Edward, Wright, Nathan, Ly, Jimmy, Blaha, Charles, Frassetto, Lynda A, Fissell, William H, Vartanian, Shant M, Roy, Shuvo

“…Reliable models of renal failure in large animals are critical to the successful translation of the next generation of renal replacement therapies (RRT) into…”
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Performance of Predictive Equations and Biochemical Measures Quantifying Net Endogenous Acid Production and the Potential Renal Acid Load by Parmenter, Benjamin H., Dymock, Michael, Banerjee, Tanushree, Sebastian, Anthony, Slater, Gary J., Frassetto, Lynda A.

“…A limited number of studies have assessed the accuracy and precision of methods for determining the net endogenous acid production (NEAP) and its components…”
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Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet by Frassetto, Lynda A, Morris, Jr, R Curtis, Sebastian, Anthony

“…We previously demonstrated that typical American net acid-producing diets predict a low-grade metabolic acidosis of severity proportional to the diet net acid…”
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Management of Osteoporosis in CKD Stages 3 to 5 by Gordon, Patricia L., RN, PhD, Frassetto, Lynda A., MD

“…Osteoporosis and chronic kidney disease (CKD) are both common conditions of older adults and both may be associated with substantial morbidity. However,…”
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Dietary acid load and renal function have varying effects on blood acid-base status and exercise performance across age and sex by Hietavala, Enni-Maria, Stout, Jeffrey R, Frassetto, Lynda A, Puurtinen, Risto, Pitkänen, Hannu, Selänne, Harri, Suominen, Harri, Mero, Antti A

“…Diet composition influences acid-base status of the body. This may become more relevant as renal functional capacity declines with aging. We examined the…”
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Effects of 12-Week Low or Moderate Dietary Acid Intake on Acid-Base Status and Kidney Function at Rest and during Submaximal Cycling by Hietavala, Enni-Maria, Ihalainen, Johanna K, Frassetto, Lynda A, Schumann, Moritz, Eklund, Daniela, Pitkänen, Hannu, Häkkinen, Keijo, Mero, Antti A

“…Prolonged effects of dietary acid intake on acid-base status and kidney function have not yet been studied in an intervention study in healthy subjects…”
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Estimation of net endogenous noncarbonic acid production in humans from diet potassium and protein contents by FRASSETTO, L. A, TODD, K. M, MORRIS, R. C, SEBASTIAN, A

“…Normal adult humans eating Western diets have chronic, low-grade metabolic acidosis, the severity of which is determined in part by the net rate of endogenous…”
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Metabolic acidosis and progression of chronic kidney disease by Frassetto, Lynda A, Hsu, Chi-yuan

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Estimates of daily net endogenous acid production in the elderly UK population: analysis of the National Diet and Nutrition Survey (NDNS) of British adults aged 65 years and over by Gannon, Richard H. T., Millward, D. Joe, Brown, Jonathan E., Macdonald, Helen M., Lovell, David P., Frassetto, Lynda A., Remer, Thomas, Lanham-New, Susan A.

“…Dietary intake has been shown to influence acid–base balance in human subjects under tightly controlled conditions. However, the net effect of food groups on…”
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11C-L-methyl methionine dynamic PET/CT of skeletal muscle: response to protein supplementation compared to L-[ring 13C6] phenylalanine infusion with serial muscle biopsy by Arentson-Lantz, Emily J., Saeed, Isra H., Frassetto, Lynda A., Masharani, Umesh, Harnish, Roy J., Seo, Youngho, VanBrocklin, Henry F., Hawkins, Randall A., Mari-Aparici, Carina, Pampaloni, Miguel H., Slater, James, Paddon-Jones, Douglas, Lang, Thomas F.

“…Objective The objective of this study was to determine if clinical dynamic PET/CT imaging with 11 C-L-methyl-methionine ( 11 C-MET) in healthy older women can…”
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Diet-induced acidosis: is it real and clinically relevant? by Pizzorno, Joseph, Frassetto, Lynda A., Katzinger, Joseph

“…The concept of diet-induced ‘acidosis’ as a cause of disease has been a subject of interest for more than a century. The present article reviews the history of…”
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Potassium by Frassetto, Lynda A., Goas, Almudena, Gannon, Richard, Lanham-New, Susan A., Lambert, Helen

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Effects of Single Dose Rifampin on the Pharmacokinetics of Fluvastatin in Healthy Volunteers by Xiang, Yue, Okochi, Hideaki, Kozachenko, Ivan, Sodhi, Jasleen K., Frassetto, Lynda A., Benet, Leslie Z.

“…The objective of this study was to determine the effects of the OATP inhibitor rifampin on pharmacokinetic of Biopharmaceutics Drug Disposition Classification…”
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Evaluating Within‐Subject Variability for Narrow Therapeutic Index Drugs by Jayachandran, Priya, Okochi, Hideaki, Frassetto, Lynda A., Park, Wansu, Fang, Lanyan, Zhao, Liang, Benet, Leslie Z.

“…The US Food and Drug Administration (FDA) reference‐scaled average bioequivalence approach scales the bioequivalence (BE) limits of narrow therapeutic index…”
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A Neglected Requirement for Optimizing Treatment of Age-Related Osteoporosis: Replenishing the Skeleton’s Base Reservoir with Net Base-Producing Diets by Sebastian, Anthony, Frassetto, Lynda A

“…Abstract Osteoporosis is a disorder of bone in which the mass of the bone is reduced and the bone’s architecture at the microscopic level is disordered…”
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Commentary to accompany the paper entitled ‘Nutritional disturbance in acid–base balance and osteoporosis: a hypothesis that disregards the essential homeostatic role of the kidney’, by Jean-Philippe Bonjour by Frassetto, Lynda A., Sebastian, Anthony

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Islet Transplantation in Type 1 Diabetic Patients Using Calcineurin Inhibitor-Free Immunosuppressive Protocols Based on T-Cell Adhesion or Costimulation Blockade by POSSELT, Andrew M, SZOT, Gregory L, VINCENTI, Flavio, BLUESTONE, Jeffrey A, STOCK, Peter G, FRASSETTO, Lynda A, MASHARANI, Umesh, TAVAKOL, Mehdi, AMIN, Raj, MCELROY, Joan, RAMOS, Marissa D, KERLAN, Robert K, FONG, Lawrence

“…The applicability of islet transplantation as treatment for type 1 diabetes is limited by long-term graft dysfunction, immunosuppressive drug toxicity, need…”
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