Search Results - "Frassetto, L"

Effect of OATP1B Transporter Inhibition on the Pharmacokinetics of Atorvastatin in Healthy Volunteers by Lau, Y Y, Huang, Y, Frassetto, L, Benet, L Z

“…The inhibition of hepatic uptake transporters, such as OATP1B1, on the pharmacokinetics of atorvastatin is unknown. Here, we investigate the effect of a model…”
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Elucidating Rifampin's Inducing and Inhibiting Effects on Glyburide Pharmacokinetics and Blood Glucose in Healthy Volunteers: Unmasking the Differential Effects of Enzyme Induction and Transporter Inhibition for a Drug and Its Primary Metabolite by Zheng, HX, Huang, Y, Frassetto, LA, Benet, LZ

“…The effects of single doses of intravenous (IV) ciprofloxacin and rifampin and of multiple doses of rifampin on glyburide exposure and blood glucose levels…”
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Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet by Frassetto, L.A, Schloetter, M, Mietus-Synder, M, Morris, R.C. Jr, Sebastian, A

“…Background: The contemporary American diet figures centrally in the pathogenesis of numerous chronic diseases--'diseases of civilization'. We investigated in…”
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Immunosuppressant Pharmacokinetics and Dosing Modifications in HIV‐1 Infected Liver and Kidney Transplant Recipients by Frassetto, L. A., Browne, M., Cheng, A., Wolfe, A. R., Roland, M. E., Stock, P. G., Carlson, L., Benet, L. Z.

“…Solid organ transplantation in human immunodeficiency virus (HIV)‐infected individuals requiring concomitant use of immunosuppressants (IS) (e.g. cyclosporine…”
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A Comparative Analysis of the Safety, Efficacy, and Cost of Islet Versus Pancreas Transplantation in Nonuremic Patients With Type 1 Diabetes by Moassesfar, S., Masharani, U., Frassetto, L.A., Szot, G.L., Tavakol, M., Stock, P.G., Posselt, A.M.

“…Few current studies compare the outcomes of islet transplantation alone (ITA) and pancreas transplantation alone (PTA) for type 1 diabetes (T1D). We examined…”
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HIV‐Infected Liver and Kidney Transplant Recipients: 1‐ and 3‐Year Outcomes by Roland, M. E., Barin, B., Carlson, L., Frassetto, L. A., Terrault, N. A., Hirose, R., Freise, C. E., Benet, L. Z., Ascher, N. L., Roberts, J. P., Murphy, B., Keller, M. J., Olthoff, K. M., Blumberg, E. A., Brayman, K. L., Bartlett, S. T., Davis, C. E., McCune, J. M., Bredt, B. M., Stablein, D. M., Stock, P. G.

“…Improvements in human immunodeficiency virus (HIV)‐associated mortality make it difficult to deny transplantation based upon futility. Outcomes in the current…”
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Hepatic Clearance, but Not Gut Availability, of Erythromycin Is Altered in Patients With End-Stage Renal Disease by Sun, H, Frassetto, L A, Huang, Y, Benet, L Z

“…Nonrenal clearance of drugs can be significantly lower in patients with end‐stage renal disease (ESRD) than in those with normal renal function. Using…”
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Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes by Masharani, U, Sherchan, P, Schloetter, M, Stratford, S, Xiao, A, Sebastian, A, Nolte Kennedy, M, Frassetto, L

“…Background/Objectives: The contemporary American diet figures centrally in the pathogenesis of numerous chronic diseases– 'diseases of civilization'–such as…”
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Islet Transplantation in Type 1 Diabetics Using an Immunosuppressive Protocol Based on the Anti‐LFA‐1 Antibody Efalizumab by Posselt, A. M., Bellin, M. D., Tavakol, M., Szot, G. L., Frassetto, L. A., Masharani, U., Kerlan, R. K., Fong, L., Vincenti, F. G., Hering, B. J., Bluestone, J. A., Stock, P. G.

“…The applicability of islet transplantation as treatment for type 1 diabetes is limited by renal and islet toxicities of currently available immunosuppressants…”
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The effect of supplementation with alkaline potassium salts on bone metabolism: a meta-analysis by Lambert, H., Frassetto, L., Moore, J. B., Torgerson, D., Gannon, R., Burckhardt, P., Lanham-New, S.

“…Summary The role of acid–base metabolism in bone health is controversial. In this meta-analysis, potassium bicarbonate and potassium citrate lowered urinary…”
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Aging, metabolic acidosis and renal failure: Interactive accelerating processes by Frassetto, L.A., Sebastian, A.

“…In this article, we hypothesize that eating a low acid (and particularly a low phosphate) diet and/or supplementing the diet with base precursors such as…”
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Established dietary estimates of net acid production do not predict measured net acid excretion in patients with Type 2 diabetes on Paleolithic–Hunter–Gatherer-type diets by Frassetto, L A, Shi, L, Schloetter, M, Sebastian, A, Remer, T

“…Background/objectives: Formulas developed to estimate diet-dependent net acid excretion (NAE) generally agree with measured values for typical Western diets…”
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Systemic modified messenger RNA for replacement therapy in alpha 1-antitrypsin deficiency by Karadagi, Ahmad, Cavedon, Alex G., Zemack, Helen, Nowak, Greg, Eybye, Marianne E., Zhu, Xuling, Guadagnin, Eleonora, White, Rebecca A., Rice, Lisa M., Frassetto, Andrea L., Strom, Stephen, Jorns, Carl, Martini, Paolo G. V., Ellis, Ewa

“…Alpha 1-antitrypsin (AAT) deficiency arises from an inherited mutation in the SERPINA1 gene. The disease causes damage in the liver where the majority of the…”
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How metabolic acidosis and oxidative stress alone and interacting may increase the risk of fracture in diabetic subjects by Frassetto, L.A, Sebastian, A

“…Abstract Subjects with either type 1 or type 2 diabetes are at higher risk for having fractures, a risk not necessarily improved by better glucose control. In…”
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Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet by Frassetto, L A, Schloetter, M, Mietus-Synder, M, Morris, R C, Sebastian, A

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No evidence that the skeletal non-response to potassium alkali supplements in healthy postmenopausal women depends on blood pressure or sodium chloride intake by Frassetto, L A, Hardcastle, A C, Sebastian, A, Aucott, L, Fraser, W D, Reid, D M, Macdonald, H M

“…Background/Objectives: In vitro studies demonstrate that bone is degraded in an acidic environment due to chemical reactions and through effects on bone cells…”
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Effects of Uptake and Efflux Transporter Inhibition on Erythromycin Breath Test Results by Frassetto, L A, Poon, S, Tsourounis, C, Valera, C, Benet, L Z

“…The erythromycin breath test (EBT) is a standard test used to evaluate the extent of CYP3A4 activity. This study examines whether presumed changes in CYP3A4…”
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Estimation of net endogenous noncarbonic acid production in humans from diet potassium and protein contents by FRASSETTO, L. A, TODD, K. M, MORRIS, R. C, SEBASTIAN, A

“…Normal adult humans eating Western diets have chronic, low-grade metabolic acidosis, the severity of which is determined in part by the net rate of endogenous…”
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Effect of Single-Dose Rifampin on the Pharmacokinetics of Warfarin in Healthy Volunteers by Frymoyer, A, Shugarts, S, Browne, M, Wu, A H B, Frassetto, L, Benet, L Z

“…Based on in vitro rat and human hepatocyte uptake studies showing inhibition of warfarin uptake in the presence of the nonspecific organic anion–transporting…”
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Effect of age on blood acid-base composition in adult humans: role of age-related renal functional decline by Frassetto, L A, Morris, Jr, R C, Sebastian, A

“…In 64 apparently healthy adult humans (ages 17-74 yr) ingesting controlled diets, we investigated the separate and combined effects of age, glomerular…”
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