Search Results - "Fraser, Simon D."

Kidney disease in the Global Burden of Disease Study 2017 by Fraser, Simon D. S., Roderick, Paul J.

“…The analyses in the 2017 Global Burden of Disease Study demonstrate the growing burden of chronic kidney disease (CKD), mainly driven by population ageing;…”
Get full text

A systematic review of the evidence for deprescribing interventions among older people living with frailty by Ibrahim, Kinda, Cox, Natalie J, Stevenson, Jennifer M, Lim, Stephen, Fraser, Simon D S, Roberts, Helen C

“…Older people living with frailty are often exposed to polypharmacy and potential harm from medications. Targeted deprescribing in this population represents an…”
Get full text

The clinical utility and cost impact of cystatin C measurement in the diagnosis and management of chronic kidney disease: A primary care cohort study by Shardlow, Adam, McIntyre, Natasha J, Fraser, Simon D S, Roderick, Paul, Raftery, James, Fluck, Richard J, McIntyre, Christopher W, Taal, Maarten W

“…To reduce over-diagnosis of chronic kidney disease (CKD) resulting from the inaccuracy of creatinine-based estimates of glomerular filtration rate (GFR), UK…”
Get full text

What are the modifiable factors of treatment burden and capacity among people with Parkinson's disease and their caregivers: A qualitative study by Tan, Qian Yue, Roberts, Helen C, Fraser, Simon D S, Amar, Khaled, Ibrahim, Kinda

“…People with long-term conditions must complete many healthcare tasks such as take medications, attend appointments, and change their lifestyle. This treatment…”
Get full text

The impact of non-alcoholic fatty liver disease and liver fibrosis on adverse clinical outcomes and mortality in patients with chronic kidney disease: a prospective cohort study using the UK Biobank by Hydes, Theresa J, Kennedy, Oliver J, Buchanan, Ryan, Cuthbertson, Daniel J, Parkes, Julie, Fraser, Simon D S, Roderick, Paul

“…Chronic kidney disease (CKD) and non-alcoholic fatty liver disease (NAFLD) frequently co-exist. We assess the impact of having NAFLD on adverse clinical…”
Get full text

Cycling for transport and public health: a systematic review of the effect of the environment on cycling by Fraser, Simon D.S., Lock, Karen

“…Background: Active transport policies are being developed across Europe designed to have health and environmental benefits. There is little evidence of impact…”
Get full text

Decision-making approaches used by UK and international health funding organisations for allocating research funds: A survey of current practice by Meadmore, Katie, Fackrell, Kathryn, Recio-Saucedo, Alejandra, Bull, Abby, Fraser, Simon D S, Blatch-Jones, Amanda

“…Innovations in decision-making practice for allocation of funds in health research are emerging; however, it is not clear to what extent these are used. This…”
Get full text

The burden of comorbidity in people with chronic kidney disease stage 3: a cohort study by Fraser, Simon D S, Roderick, Paul J, May, Carl R, McIntyre, Natasha, McIntyre, Christopher, Fluck, Richard J, Shardlow, Adam, Taal, Maarten W

“…Multimorbidity is a growing concern for healthcare systems, with many countries experiencing demographic transition to older population profiles. Chronic…”
Get full text

Quality of life in older adults with chronic kidney disease and transient changes in renal function: Findings from the Oxford Renal cohort by Busa, Isabella, Ordóñez-Mena, José M, Yang, Yaling, Wolstenholme, Jane, Petrou, Stavros, Taylor, Clare J, O'Callaghan, Chris A, Fraser, Simon D. S, Taal, Maarten W, McManus, Richard J, Hirst, Jennifer A, Hobbs, F. D. Richard

“…Background Quality of life (QoL) is an important measure of disease burden and general health perception. The relationship between early chronic kidney disease…”
Get full text

Change in treatment burden among people with multimorbidity: Protocol of a follow up survey and development of efficient measurement tools for primary care by Hounkpatin, Hilda O, Roderick, Paul, Morris, James E, Harris, Scott, Watson, Forbes, Dambha-Miller, Hajira, Roberts, Helen, Walsh, Bronagh, Smith, Dianna, Fraser, Simon D S

“…Treatment burden is the effort required of patients to look after their health and the impact this has on their functioning and wellbeing. It is likely…”
Get full text

What makes a multidisciplinary medication review and deprescribing intervention for older people work well in primary care? A realist review and synthesis by Radcliffe, Eloise, Servin, Renée, Cox, Natalie, Lim, Stephen, Tan, Qian Yue, Howard, Clare, Sheikh, Claire, Rutter, Paul, Latter, Sue, Lown, Mark, Brad, Lawrence, Fraser, Simon D S, Bradbury, Katherine, Roberts, Helen C, Saucedo, Alejandra Recio, Ibrahim, Kinda

“…A third of older people take five or more regular medications (polypharmacy). Conducting medication reviews in primary care is key to identify and reduce/ stop…”
Get full text

The dynamics of frailty development and progression in older adults in primary care in England (2006-2017): a retrospective cohort profile by Fogg, Carole, Fraser, Simon D S, Roderick, Paul, de Lusignan, Simon, Clegg, Andrew, Brailsford, Sally, Barkham, Abigail, Patel, Harnish P, Windle, Vivienne, Harris, Scott, Zhu, Shihua, England, Tracey, Evenden, Dave, Lambert, Francesca, Walsh, Bronagh

“…Frailty is a common condition in older adults and has a major impact on patient outcomes and service use. Information on the prevalence in middle-aged adults…”
Get full text

DEM simulation of continuous tablet coating: Effects of tablet shape and fill level on inter-tablet coating variability by Suzzi, Daniele, Toschkoff, Gregor, Radl, Stefan, Machold, Daniel, Fraser, Simon D., Glasser, Benjamin J., Khinast, Johannes G.

“…Tablet coating is a common pharmaceutical technique of applying a thin polymer-based film to a tablet or a granule containing active pharmaceutical ingredients…”
Get full text

Ethnic minority disparities in progression and mortality of pre-dialysis chronic kidney disease: a systematic scoping review by Hounkpatin, Hilda O, Fraser, Simon D.S, Honney, Rory, Dreyer, Gavin, Brettle, Alison, Roderick, Paul J

“…Abstract Background There are a growing number of studies on ethnic differences in progression and mortality for pre-dialysis chronic kidney disease (CKD), but…”
Get full text

Exploration of chronic kidney disease prevalence estimates using new measures of kidney function in the health survey for England by Fraser, Simon D S, Aitken, Grant, Taal, Maarten W, Mindell, Jennifer S, Moon, Graham, Day, Julie, O'Donoghue, Donal, Roderick, Paul J

“…Chronic kidney disease (CKD) diagnosis relies on glomerular filtration rate (eGFR) estimation, traditionally using the creatinine-based Modification of Diet in…”
Get full text

Aspirin to target arterial events in chronic kidney disease (ATTACK): study protocol for a multicentre, prospective, randomised, open-label, blinded endpoint, parallel group trial of low-dose aspirin vs. standard care for the primary prevention of cardiovascular disease in people with chronic kidney disease by Gallagher, Hugh, Dumbleton, Jennifer, Maishman, Tom, Whitehead, Amy, Moore, Michael V, Fuat, Ahmet, Fitzmaurice, David, Henderson, Robert A, Lord, Joanne, Griffith, Kathryn E, Stevens, Paul, Taal, Maarten W, Stevenson, Diane, Fraser, Simon D, Lown, Mark, Hawkey, Christopher J, Roderick, Paul J

“…Chronic kidney disease (CKD) is a very common long-term condition and powerful risk factor for cardiovascular disease (CVD). Low-dose aspirin is of proven…”
Get full text

Prevalence of chronic kidney disease in adults in England: comparison of nationally representative cross-sectional surveys from 2003 to 2016 by Hounkpatin, Hilda O, Harris, S, Fraser, Simon D S, Day, Julie, Mindell, Jennifer S, Taal, Maarten W, O'Donoghue, Donal, Roderick, Paul J

“…ObjectivesTo identify recent trends in chronic kidney disease (CKD) prevalence in England and explore their association with changes in sociodemographic,…”
Get full text

Correction to: The burden of comorbidity in people with chronic kidney disease stage 3: a cohort study by Fraser, Simon D S, Roderick, Paul J, May, Carl R, McIntyre, Natasha, McIntyre, Christopher, Fluck, Richard J, Shardlow, Adam, Taal, Maarten W

“…An amendment to this paper has been published and can be accessed via the original article…”
Get full text

Assessment of proteinuria in patients with chronic kidney disease stage 3: albuminuria and non-albumin proteinuria by Fraser, Simon D S, Roderick, Paul J, McIntyre, Natasha J, Harris, Scott, McIntyre, Christopher, Fluck, Richard, Taal, Maarten W

“…Proteinuria assessment is key in investigating chronic kidney disease (CKD) but uncertainty exists regarding optimal methods. Albuminuria, reflecting…”
Get full text

Distinct immune regulatory receptor profiles linked to altered monocyte subsets in sarcoidosis by Fraser, Simon D, Crooks, Michael G, Kaye, Paul M, Hart, Simon P

“…In sarcoidosis, blood monocytes, circulating precursors of granuloma macrophages, display enhanced inflammatory cytokine production, reduced expression of the…”
Get full text