Search Results - "Fraser, Paul E."

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function by Murakami, Tetsuro, Qamar, Seema, Lin, Julie Qiaojin, Schierle, Gabriele S. Kaminski, Rees, Eric, Miyashita, Akinori, Costa, Ana R., Dodd, Roger B., Chan, Fiona T.S., Michel, Claire H., Kronenberg-Versteeg, Deborah, Li, Yi, Yang, Seung-Pil, Wakutani, Yosuke, Meadows, William, Ferry, Rodylyn Rose, Dong, Liang, Tartaglia, Gian Gaetano, Favrin, Giorgio, Lin, Wen-Lang, Dickson, Dennis W., Zhen, Mei, Ron, David, Schmitt-Ulms, Gerold, Fraser, Paul E., Shneider, Neil A., Holt, Christine, Vendruscolo, Michele, Kaminski, Clemens F., St George-Hyslop, Peter

“…The mechanisms by which mutations in FUS and other RNA binding proteins cause ALS and FTD remain controversial. We propose a model in which low-complexity (LC)…”
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Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer's Disease by Newsholme, Philip, Fraser, Paul E., Wijesekara, Nadeeja, Rowles, Joanne, Sabale, Miheer, Medic, Sandra, Cruzat, Vinicius F., Keane, Kevin N., Verdile, Giuseppe, Martins, Ralph N.

“…Type 2 diabetes (T2DM), Alzheimer’s disease (AD), and insulin resistance are age-related conditions and increased prevalence is of public concern. Recent…”
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The Link Between Tau and Insulin Signaling: Implications for Alzheimer's Disease and Other Tauopathies by Gonçalves, Rafaella Araujo, Wijesekara, Nadeeja, Fraser, Paul E, De Felice, Fernanda G

“…The microtubule-associated protein tau (MAPT) is mainly identified as a tubulin binding protein essential for microtubule dynamics and assembly and for neurite…”
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α-Synuclein Regulates Peripheral Insulin Secretion and Glucose Transport by Wijesekara, Nadeeja, Ahrens, Rosemary, Wu, Ling, Langman, Tammy, Tandon, Anurag, Fraser, Paul E.

“…Aim Population based studies indicate a positive association between type 2 diabetes (T2D) and Parkinson’s disease (PD) where there is an increased risk of…”
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The Adult Mouse and Human Pancreas Contain Rare Multipotent Stem Cells that Express Insulin by Smukler, Simon R., Arntfield, Margot E., Razavi, Rozita, Bikopoulos, George, Karpowicz, Phillip, Seaberg, Raewyn, Dai, Feihan, Lee, Simon, Ahrens, Rosemary, Fraser, Paul E., Wheeler, Michael B., van der Kooy, Derek

“…The search for putative precursor cells within the pancreas has been the focus of extensive research. Previously, we identified rare pancreas-derived…”
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SUMO1 Modification of Tau in Progressive Supranuclear Palsy by Takamura, Hironori, Nakayama, Yoshiaki, Ito, Hidefumi, Katayama, Taiichi, Fraser, Paul E., Matsuzaki, Shinsuke

“…Small ubiquitin-like modifiers (SUMO) have been implicated in several neurodegenerative diseases. SUMO1 conjugation has been shown to promote aggregation and…”
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SARS-CoV-2 Nucleocapsid Protein Induces Tau Pathological Changes That Can Be Counteracted by SUMO2 by Orsini, Franca, Bosica, Marco, Martucci, Annacarla, De Paola, Massimiliano, Comolli, Davide, Pascente, Rosaria, Forloni, Gianluigi, Fraser, Paul E, Arancio, Ottavio, Fioriti, Luana

“…Neurologic manifestations are an immediate consequence of SARS-CoV-2 infection, the etiologic agent of COVID-19, which, however, may also trigger long-term…”
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Combination of human tau and islet amyloid polypeptide exacerbates metabolic dysfunction in transgenic mice by Wijesekara, Nadeeja, Gonçalves, Rafaella Araujo, Ahrens, Rosemary, Ha, Kathy, De Felice, Fernanda G, Fraser, Paul E

“…Amyloid plaques and neurofibrillary tangles composed of hyperphosphorylated tau are important contributors to Alzheimer's disease (AD). Tau also impacts…”
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Behavioral Abnormalities in Knockout and Humanized Tau Mice by Gonçalves, Rafaella Araujo, Wijesekara, Nadeeja, Fraser, Paul E, De Felice, Fernanda G

“…Microtubule-associated protein tau assists in stabilizing microtubules and has been particularly implicated in Alzheimer's disease (AD). Given the importance…”
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SUMO1 impact on Alzheimer disease pathology in an amyloid-depositing mouse model by Knock, Erin, Matsuzaki, Shinsuke, Takamura, Hironori, Satoh, Kanayo, Rooke, Grace, Han, Kyung, Zhang, Hong, Staniszewski, Agnieszka, Katayama, Taiichi, Arancio, Ottavio, Fraser, Paul E.

“…Small ubiquitin-related modifiers (SUMOs) conjugated or bound to target proteins can affect protein trafficking, processing and solubility. SUMOylation has…”
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Brain‐Penetrating and Disease Site‐Targeting Manganese Dioxide‐Polymer‐Lipid Hybrid Nanoparticles Remodel Microenvironment of Alzheimer's Disease by Regulating Multiple Pathological Pathways by Park, Elliya, Li, Lily Yi, He, Chunsheng, Abbasi, Azhar Z., Ahmed, Taksim, Foltz, Warren D., O'Flaherty, Regan, Zain, Maham, Bonin, Robert P., Rauth, Andrew M., Fraser, Paul E., Henderson, Jeffrey T., Wu, Xiao Yu

“…Finding effective disease‐modifying treatment for Alzheimer's disease remains challenging due to an array of factors contributing to the loss of neural…”
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SUMO1 Affects Synaptic Function, Spine Density and Memory by Matsuzaki, Shinsuke, Lee, Linda, Knock, Erin, Srikumar, Tharan, Sakurai, Mikako, Hazrati, Lili-Naz, Katayama, Taiichi, Staniszewski, Agnieszka, Raught, Brian, Arancio, Ottavio, Fraser, Paul E.

“…Small ubiquitin-like modifier-1 (SUMO1) plays a number of roles in cellular events and recent evidence has given momentum for its contributions to neuronal…”
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SUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3 by Drisaldi, Bettina, Colnaghi, Luca, Fioriti, Luana, Rao, Nishta, Myers, Cory, Snyder, Anna M., Metzger, Daniel J., Tarasoff, Jenna, Konstantinov, Edward, Fraser, Paul E., Manley, James L., Kandel, Eric R.

“…Protein synthesis is crucial for the maintenance of long-term-memory-related synaptic plasticity. The prion-like cytoplasmic polyadenylation element-binding…”
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Retraction Note to: Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors by Wislet-Gendebien, Sabine, Visanji, Naomi P, Whitehead, Shawn N, Marsilio, Diana, Hou, Weimin, Figeys, Daniel, Fraser, Paul E, Bennett, Steffany A. L, Tandon, Anurag

“…This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12868-021-00644-1…”
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Structural Interactions between Inhibitor and Substrate Docking Sites Give Insight into Mechanisms of Human PS1 Complexes by Li, Yi, Lu, Stephen Hsueh-Jeng, Tsai, Ching-Ju, Bohm, Christopher, Qamar, Seema, Dodd, Roger B., Meadows, William, Jeon, Amy, McLeod, Adam, Chen, Fusheng, Arimon, Muriel, Berezovska, Oksana, Hyman, Bradley T., Tomita, Taisuke, Iwatsubo, Takeshi, Johnson, Christopher M., Farrer, Lindsay A., Schmitt-Ulms, Gerold, Fraser, Paul E., St George-Hyslop, Peter H.

“…Presenilin-mediated endoproteolysis of transmembrane proteins plays a key role in physiological signaling and in the pathogenesis of Alzheimer disease and some…”
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Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein by Martinez-Valbuena, Ivan, Valenti-Azcarate, Rafael, Amat-Villegas, Irene, Marcilla, Irene, Marti-Andres, Gloria, Caballero, Maria-Cristina, Riverol, Mario, Tuñon, María-Teresa, Fraser, Paul E, Luquin, María-Rosario

“…Protein misfolding diseases refer to a variety of disorders that develop as a consequence of the misfolding of proteins in various organs. The etiologies of…”
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The in Vivo Brain Interactome of the Amyloid Precursor Protein by Bai, Yu, Markham, Kelly, Chen, Fusheng, Weerasekera, Rasanjala, Watts, Joel, Horne, Patrick, Wakutani, Yosuke, Bagshaw, Rick, Mathews, Paul M., Fraser, Paul E., Westaway, David, St. George-Hyslop, Peter, Schmitt-Ulms, Gerold

“…Despite intense research efforts, the physiological function and molecular environment of the amyloid precursor protein has remained enigmatic. Here we…”
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Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice by Ruiz-Riquelme, Alejandro, Mao, Alison, Barghash, Marim M, Lau, Heather H C, Stuart, Erica, Kovacs, Gabor G, Nilsson, K Peter R, Fraser, Paul E, Schmitt-Ulms, Gerold, Watts, Joel C

“…When injected into genetically modified mice, aggregates of the amyloid-β (Aβ) peptide from the brains of Alzheimer's disease (AD) patients or transgenic AD…”
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Structural biology of presenilin 1 complexes by Li, Yi, Bohm, Christopher, Dodd, Roger, Chen, Fusheng, Qamar, Seema, Schmitt-Ulms, Gerold, Fraser, Paul E, St George-Hyslop, Peter H

“…The presenilin genes were first identified as the site of missense mutations causing early onset autosomal dominant familial Alzheimer's disease. Subsequent…”
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Amyloid inhibitors enhance survival of cultured human islets by Potter, Kathryn J., Scrocchi, Louise A., Warnock, Garth L., Ao, Ziliang, Younker, Marika A., Rosenberg, Lawrence, Lipsett, Mark, Verchere, C. Bruce, Fraser, Paul E.

“…Amyloid fibrils created by misfolding and aggregation of proteins are a major pathological feature in a variety of degenerative diseases. Therapeutic…”
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