Search Results - "Fraser, I. J."

The rapid identification of drug metabolites using capillary liquid chromatography coupled to an ion trap mass spectrometer by Dear, G. J., Ayrton, J., Plumb, R., Fraser, I. J.

“…Capillary liquid chromatography (LC) using a 320 µm column and a flow rate of 10 µL/min has been coupled to an ion trap mass spectrometer using electrospray…”
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Prescribing in a pandemic: best use of oseltamivir in paediatric intensive care by Seale, A C, Toussaint, F S, Finn, A, Fraser, J I

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Pharmacokinetics of 619C89, a novel neuronal sodium channel inhibitor, in acute stroke patients after loading and discrete maintenance infusions by HUSSEIN, Z., FRASER, I. J., LEES, K. R., MUIR, K. W., LUNNON, M. W., HOBBIGER, S. F., POSNER, J.

“…1This was a multi‐centre, placebo controlled, randomized, dose‐escalating design study in which five dosing regimens of 619C89/placebo were evaluated in 48…”
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The application of fast gradient capillary liquid chromatography/mass spectrometry to the analysis of pharmaceuticals in biofluids by Plumb, R. S., Dear, G. J., Mallett, D., Fraser, I. J., Ayrton, J., Ioannou, C.

“…Fast gradient capillary high performance liquid chromatography (HPLC) coupled to a mass spectrometer has been successfully used for the analysis of…”
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A rapid and efficient approach to metabolite identification using nuclear magnetic resonance spectroscopy, liquid chromatography/mass spectrometry and liquid chromatography/nuclear magnetic resonance spectroscopy/sequential mass spectrometry by Dear, G. J., Ayrton, J., Plumb, R., Sweatman, B. C., Ismail, I. M., Fraser, I. J., Mutch, P. J.

“…High‐performance liquid chromatography, nuclear magnetic resonance (NMR) spectroscopy and sequential mass spectrometry (MSn) have been combined to allow rapid…”
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Determination of the acylcoenzyme A cholesterol acyltransferase inhibitor 447C88 in plasma using gas chromatography-mass spectrometry and liquid chromatography atmospheric pressure chemical ionisation tandem mass spectrometry by Fraser, I.J., Clare, R.A., Pleasance, S.

“…Two mass spectrometry-based methods are described for the determination of 447C88 (I), a novel inhibitor of acylcoenzyme A cholesterol acyltransferase (ACAT),…”
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The use of capillary high performance liquid chromatography with electrospray mass spectrometry for the analysis of small volume blood samples from serially bled mice to determine the pharmacokinetics of early discovery compounds by Fraser, Ian J., Dear, Gordon J., Plumb, Robert, L'Affineur, Matthew, Fraser, Donna, Skippen, Alison J.

“…The methodology described demonstrates, for the first time, the feasibility of performing pharmacokinetic studies in the serially bled mouse model to support…”
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Use of liquid chromatography–tandem mass spectrometry for the quantitative and qualitative analysis of an antipsychotic agent and its metabolites in human plasma and urine by Dear, Gordon J, Fraser, Ian J, Patel, Dipak K, Long, Jeffrey, Pleasance, Stephen

“…The use of liquid chromatography–tandem mass spectrometry (LC–MS–MS) for the quantitative analysis of an `atypical' antipsychotic agent in human plasma is…”
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1,4-Benzodiazepines as Inhibitors of Respiratory Syncytial Virus. The Identification of a Clinical Candidate by Henderson, E A, Alber, D G, Baxter, R C, Bithell, S K, Budworth, J, Carter, M C, Chubb, A, Cockerill, G S, Dowdell, VCL, Fraser, I J, Harris, R A, Keegan, S J, Kelsey, R D, Lumley, JA

“…Respiratory syncytial virus (RSV) is the cause of one-fifth of all lower respiratory tract infections worldwide and is increasingly being recognized as…”
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Use of liquid chromatography-tandem mass spectrometry for the quantitative and qualitative analysis of an antipsychotic agent and its metabolites in human plasma and urine: Current practice of liquid chromatography-mass spectrometry by DEAR, G. J, FRASER, I. J, PATEL, D. K, LONG, J, PLEASANCE, S

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TCRBV14S1 and Rheumatoid Arthritis Revisited: Abnormalities in the percentage of transcribed TCRBV14S1 family genes in PBMC from rheumatoid arthritis patients by ABBOTT, W. G. H, TAN, P. L. J, GEURSEN, A, FRASER, J. D, FORBES, L, SIMPSON, I. J, YUAN, S, SKINNER, M. A

“…The purpose of this study was to identify Vbeta gene families that are associated with rheumatoid arthritis (RA). A PCR-based assay was used to compare the…”
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