Search Results - "Fraser, Graham"

Criteria for Iron Deficiency in Patients With Heart Failure by Masini, Gabriele, Graham, Fraser J, Pellicori, Pierpaolo, Cleland, John G F, Cuthbert, Joseph J, Kazmi, Syed, Inciardi, Riccardo M, Clark, Andrew L

“…Guidelines on heart failure (HF) define iron deficiency (ID) as a serum ferritin <100 ng/mL or, when 100-299 ng/mL, a transferrin saturation (TSAT) <20%…”
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Redefining both iron deficiency and anaemia in cardiovascular disease by Cleland, John G F, Pellicori, Pierpaolo, Graham, Fraser J

“…Graphical Abstract Graphical Abstract Strategies for Correction of Iron Deficiency in Patients with Cardiovascular Disease…”
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Intravenous iron in patients with heart failure and iron deficiency: an updated meta‐analysis by Graham, Fraser J., Pellicori, Pierpaolo, Kalra, Paul R., Ford, Ian, Bruzzese, Dario, Cleland, John G.F.

“…Aims For patients with heart failure (HF) and iron deficiency (ID), randomized trials suggest that intravenous (IV) iron reduces hospitalizations for heart…”
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Brain homogenates from human tauopathies induce tau inclusions in mouse brain by Clavaguera, Florence, Akatsu, Hiroyasu, Fraser, Graham, Crowther, R. Anthony, Frank, Stephan, Hench, Jürgen, Probst, Alphonse, Winkler, David T., Reichwald, Julia, Staufenbiel, Matthias, Ghetti, Bernardino, Goedert, Michel, Tolnay, Markus

“…Filamentous inclusions made of hyperphosphorylated tau are characteristic of numerous human neurodegenerative diseases, including Alzheimer’s disease,…”
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Treating iron deficiency in patients with heart failure: what, why, when, how, where and who by Graham, Fraser J, Guha, Kaushik, Cleland, John G, Kalra, Paul R

“…For patients with heart failure and reduced or mildly reduced left ventricular ejection fraction, iron deficiency is common and associated with more severe…”
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Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways by Evans, Lewis D., Wassmer, Thomas, Fraser, Graham, Smith, James, Perkinton, Michael, Billinton, Andrew, Livesey, Frederick J.

“…In Alzheimer’s disease, neurofibrillary tangle pathology appears to spread along neuronal connections, proposed to be mediated by the release and uptake of…”
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Alterations in left atrial and left ventricular coupling in mixed aortic valve disease by Sooriyakanthan, Maala, Graham, Fraser J, Ho, Natalie, Leong-Poi, Howard, Tsang, Wendy

“…Abstract Aims To characterize left atrial (LA) and left ventricular (LV) function and atrioventricular (AV) coupling in patients with moderate mixed aortic…”
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Natural history and prognostic significance of iron deficiency and anaemia in ambulatory patients with chronic heart failure by Graham, Fraser J., Masini, Gabriele, Pellicori, Pierpaolo, Cleland, John G.F., Greenlaw, Nicola, Friday, Jocelyn, Kazmi, Syed, Clark, Andrew L.

“…Aims Iron deficiency (ID) and anaemia are common in heart failure; less is known about changes over time. Methods and results We investigated prevalence,…”
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Assessment of haemoglobin and serum markers of iron deficiency in people with cardiovascular disease by Graham, Fraser J, Friday, Jocelyn M, Pellicori, Pierpaolo, Greenlaw, Nicola, Cleland, John Gf

“…The prevalence of anaemia and iron deficiency and their prognostic association with cardiovascular disease have rarely been explored at population level…”
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Prenatal Exercise and Cardiovascular Health (PEACH) Study: Impact on Muscle Sympathetic Nerve (Re)Activity by SKOW, RACHEL J., FRASER, GRAHAM M., STEINBACK, CRAIG D., DAVENPORT, MARGIE H.

“…PURPOSEWomen who develop gestational hypertension have evidence of elevated muscle sympathetic nerve activity (MSNA) in early pregnancy which continues to rise…”
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The Ghost in the Mirror: Self-Haunting in Good Morning, Midnight by Fraser, Graham

“…Jean Rhys‘s novel Good Morning, Midnight is saturated with scenes of mirror-gazing. This article reads these scenes as characteristic of a spectro-modernist…”
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Transmission and spreading of tauopathy in transgenic mouse brain by Crowther, R. Anthony, Clavaguera, Florence, Abramowski, Dorothee, Goedert, Michel, Bolmont, Tristan, Probst, Alphonse, Tolnay, Markus, Fraser, Graham, Staufenbiel, Matthias, Stalder, Anna K, Jucker, Mathias, Beibel, Martin, Frank, Stephan

“…Hyperphosphorylated tau makes up the filamentous intracellular inclusions of several neurodegenerative diseases, including Alzheimer's disease. In the disease…”
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Zucker Diabetic‐Sprague Dawley (ZDSD) rat: Type 2 diabetes translational research model by Wang, Andrea N., Carlos, Joselia, Fraser, Graham M., McGuire, John J.

“…New Findings What is the topic of this review? The Zucker Diabetic‐Sprague Dawley (ZDSD) rat is in the early adoption phase of use by researchers in the fields…”
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Intravenous iron for heart failure with evidence of iron deficiency: a meta-analysis of randomised trials by Graham, Fraser J., Pellicori, Pierpaolo, Ford, Ian, Petrie, Mark C., Kalra, Paul R., Cleland, John G. F.

“…Background The recent AFFIRM-AHF trial assessing the effect of intravenous (IV) iron on outcomes in patients hospitalised with worsening heart failure who had…”
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Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo by Schofield, Darren J., Irving, Lorraine, Calo, Laura, Bogstedt, Anna, Rees, Gareth, Nuccitelli, Annalisa, Narwal, Rajesh, Petrone, Marcella, Roberts, Jennifer, Brown, Lee, Cusdin, Fiona, Dosanjh, Bhupinder, Lloyd, Christopher, Dobson, Claire, Gurrell, Ian, Fraser, Graham, McFarlane, Mary, Rockenstein, Edward, Spencer, Brian, Masliah, Eliezer, Spillantini, Maria Grazia, Tan, Keith, Billinton, Andrew, Vaughan, Tris, Chessell, Iain, Perkinton, Michael S.

“…There are no approved drug therapies that can prevent or slow the progression of Parkinson's disease (PD). Accumulation and aggregation of α-synuclein protein…”
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Endothelium dysfunction in hind limb arteries of male Zucker Diabetic-Sprague Dawley rats by Wang, Andrea N., Carlos, Joselia, Singh, Krishna K., Fraser, Graham M., McGuire, John J.

“…[Display omitted] Endothelium dysfunction produces peripheral vascular disease comorbidities in type 2 diabetes, including hypertension, and critical limb…”
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Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice by Ozcelik, Sefika, Fraser, Graham, Castets, Perrine, Schaeffer, Véronique, Skachokova, Zhiva, Breu, Karin, Clavaguera, Florence, Sinnreich, Michael, Kappos, Ludwig, Goedert, Michel, Tolnay, Markus, Winkler, David Theo

“…Altered autophagy contributes to the pathogenesis of Alzheimer's disease and other tauopathies, for which curative treatment options are still lacking. We have…”
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Clamping Skeletal Muscle PO 2 Eliminates Hyperinsulinemic Microvascular Blood Flow Response by Wells, Brenda N, Russell McEvoy, Gaylene M, Shogan, Hamza, Kiley, Meghan E, Fraser, Graham M

“…To determine if insulin mediated hyperemia is partially dependent on local muscle oxygen concentration. The blood flow responses to insulin are partially…”
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Loop diuretic therapy with or without heart failure: impact on prognosis by Friday, Jocelyn M, Cleland, John G F, Pellicori, Pierpaolo, Wolters, Maria K, McMurray, John J V, Jhund, Pardeep S, Forsyth, Paul, McAllister, David A, Graham, Fraser J, Jones, Yola, Lewsey, Jim

“…Many patients are prescribed loop diuretics without a diagnostic record of heart failure. Little is known about their characteristics and prognosis. Glasgow…”
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Blunted sympathetic neurovascular transduction during normotensive pregnancy by Steinback, Craig D., Fraser, Graham M., Usselman, Charlotte W., Reyes, Laura M., Julian, Colleen G., Stickland, Michael K., Chari, Radha S., Khurana, Rshmi, Davidge, Sandra T., Davenport, Margie H.

“…Key points Normotensive pregnancy is associated with elevated sympathetic nervous system activity yet normal or reduced blood pressure. It represents a unique…”
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