Search Results - "Fraser, F."

C- and N‑Metalated Nitriles: The Relationship between Structure and Selectivity by Yang, Xun, Fleming, Fraser F

“…Conspectus Metalated nitriles are exceptional nucleophiles capable of forging highly hindered stereocenters in cases where enolates are unreactive. The…”
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Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore by Fleming, Fraser F, Yao, Lihua, Ravikumar, P. C, Funk, Lee, Shook, Brian C

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Sunk‐Cost Bias and Knowing When to Terminate a Research Project by Perignat, Elaine, Fleming, Fraser F.

“…Scientific research is an open‐ended quest where success usually triumphs over failure. The tremendous success of science obscures the tendency for the…”
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The inflammatory response to extracorporeal membrane oxygenation (ECMO): a review of the pathophysiology by Millar, Jonathan E, Fanning, Jonathon P, McDonald, Charles I, McAuley, Daniel F, Fraser, John F

“…Extracorporeal membrane oxygenation (ECMO) is a technology capable of providing short-term mechanical support to the heart, lungs or both. Over the last…”
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Effects of Exercise on Treatment-Related Adverse Effects for Patients With Prostate Cancer Receiving Androgen-Deprivation Therapy: A Systematic Review by GARDNER, Jason R, LIVINGSTON, Patricia M, FRASER, Steve F

“…Androgen-deprivation therapy is a commonly used treatment for men with prostate cancer; however, the adverse effects can be detrimental to patient health and…”
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Management of antiplatelet therapy in patients undergoing neuroendovascular procedures by Kim, Keri S, Fraser, Justin F, Grupke, Stephen, Cook, Aaron M

“…Neuroendovascular techniques for treating cerebral aneurysms and other cerebrovascular pathology are increasingly becoming the standard of care. Intraluminal…”
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Use of high-flow nasal cannula oxygenation in ICU adults: a narrative review by Papazian, Laurent, Corley, Amanda, Hess, Dean, Fraser, John F., Frat, Jean-Pierre, Guitton, Christophe, Jaber, Samir, Maggiore, Salvatore M., Nava, Stefano, Rello, Jordi, Ricard, Jean-Damien, Stephan, François, Trisolini, Rocco, Azoulay, Elie

“…Oxygen therapy can be delivered using low-flow, intermediate-flow (air entrainment mask), or high-flow devices. Low/intermediate-flow oxygen devices have…”
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Anterior approaches to fusion of the cervical spine : a metaanalysis of fusion rates by FRASER, Justin F, HÄRTL, Roger

“…Anterior cervical discectomy (ACD), ACD with interbody fusion (ACDF), ACDF with placement of an anterior plate system (ACDFP), corpectomy, and corpectomy with…”
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Early versus late tracheostomy: what do patients want? by Sutt, Anna-Liisa, Fraser, John F

“…[1] failed to find an association between timing of tracheostomy and mortality, ICU or hospital length of stay (LOS), or neurological outcomes (mRS) when…”
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The epidemiology of silent brain infarction: a systematic review of population-based cohorts by Fanning, Jonathon P, Wong, Andrew A, Fraser, John F

“…Cerebral infarction is a commonly observed radiological finding in the absence of corresponding, clinical symptomatology, the so-called silent brain infarction…”
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Heterocycles via SiCl4‑Promoted Isocyanide Additions to Oxonitriles by Kornfeind, John, Allen, James E., Keller, Taylor M., Fleming, Fraser F.

“…SiCl4 promotes isocyanide additions to oxoalkenenitriles to selectively generate 3-acylpyrroles, 2-aminofurans, or pyrrolidinones. Cyclic oxoalkenenitriles add…”
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Catalytic Isonitrile Insertions and Condensations Initiated by RNC-X Complexation by Chakrabarty, Suravi, Choudhary, Shruti, Doshi, Arpit, Liu, Fa-Qiang, Mohan, Rishabh, Ravindra, Manasa P., Shah, Dhruv, Yang, Xun, Fleming, Fraser F.

“…Isonitriles are delicately poised chemical entities capable of being coaxed to react as nucleophiles or electrophiles. Directing this tunable reactivity with…”
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ECMO use in COVID-19: lessons from past respiratory virus outbreaks-a narrative review by Cho, Hwa Jin, Heinsar, Silver, Jeong, In Seok, Shekar, Kiran, Li Bassi, Gianluigi, Jung, Jae Seung, Suen, Jacky Y, Fraser, John F

“…The spread of coronavirus disease 2019 (COVID-19) continues to grow exponentially in most countries, posing an unprecedented burden on the healthcare sector…”
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Protein-bound drugs are prone to sequestration in the extracorporeal membrane oxygenation circuit: results from an ex vivo study by Shekar, Kiran, Roberts, Jason A, Mcdonald, Charles I, Ghassabian, Sussan, Anstey, Chris, Wallis, Steven C, Mullany, Daniel V, Fung, Yoke L, Fraser, John F

“…Vital drugs may be degraded or sequestered in extracorporeal membrane oxygenation (ECMO) circuits, with lipophilic drugs considered to be particularly…”
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Heterocycles via SiCl 4 -Promoted Isocyanide Additions to Oxonitriles by Kornfeind, John, Allen, James E, Keller, Taylor M, Fleming, Fraser F

“…SiCl promotes isocyanide additions to oxoalkenenitriles to selectively generate 3-acylpyrroles, 2-aminofurans, or pyrrolidinones. Cyclic oxoalkenenitriles add…”
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Polar-Radical Cyclization Cascades with Magnesiated Nitriles by Bolgunas, Stephen, Paleo, Ehecatl, Alwedi, Embarek, Wei, Yunjing, Keller, Taylor M., Fleming, Fraser F.

“…Naphthalene converts magnesiated ω-alkenylnitriles into bi- and tricyclic ketones via a polar-radical addition–cyclization cascade. One-electron oxidation of…”
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Extracorporeal life support devices and strategies for management of acute cardiorespiratory failure in adult patients: a comprehensive review by Shekar, Kiran, Mullany, Daniel V, Thomson, Bruce, Ziegenfuss, Marc, Platts, David G, Fraser, John F

“…Evolution of extracorporeal life support (ECLS) technology has added a new dimension to the intensive care management of acute cardiac and/or respiratory…”
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Dearomatization of aromatic asmic isocyanides to complex cyclohexadienes by Altundas, Bilal, Alwedi, Embarek, Song, Zhihui, Gogoi, Achyut Ranjan, Dykstra, Ryan, Gutierrez, Osvaldo, Fleming, Fraser F.

“…A dearomatization-dislocation-coupling cascade rapidly transforms aromatic isocyanides into highly functionalized cyclohexadienes. The facile cascade installs…”
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Isonitrile alkylations: a rapid route to imidazo[1,5-a]pyridines by Li, Yajun, Chao, Allen, Fleming, Fraser F

“…Metalated arylmethylisonitriles readily add to 2-chloropyridines to afford imidazo[1,5-a]pyridines. Analogous additions to imidoyl chlorides and a…”
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Pharmacokinetic changes in patients receiving extracorporeal membrane oxygenation by Shekar, Kiran, FCICM, Fraser, John F., PhD, Smith, Maree T., PhD, Roberts, Jason A., PhD

“…Abstract Extracorporeal membrane oxygenation (ECMO) is a form of prolonged cardiopulmonary bypass used to temporarily sustain cardiac and/or respiratory…”
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