Search Results - "Fraser, Deborah A."

Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells by Benoit, Marie E, Clarke, Elizabeth V, Morgado, Pedro, Fraser, Deborah A, Tenner, Andrea J

“…Deficiency in C1q, the recognition component of the classical complement cascade and a pattern recognition receptor involved in apoptotic cell clearance, leads…”
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A dramatic increase of C1q protein in the CNS during normal aging by Stephan, Alexander H, Madison, Daniel V, Mateos, José María, Fraser, Deborah A, Lovelett, Emilie A, Coutellier, Laurence, Kim, Leo, Tsai, Hui-Hsin, Huang, Eric J, Rowitch, David H, Berns, Dominic S, Tenner, Andrea J, Shamloo, Mehrdad, Barres, Ben A

“…The decline of cognitive function has emerged as one of the greatest health threats of old age. Age-related cognitive decline is caused by an impacted neuronal…”
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C1q enhances microglial clearance of apoptotic neurons and neuronal blebs, and modulates subsequent inflammatory cytokine production by Fraser, Deborah A, Pisalyaput, Karntipa, Tenner, Andrea J

“…J. Neurochem. (2010) 112, 733-743. The expression of C1q, a recognition molecule of the complement system, is up-regulated following neuronal injury and is…”
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C1q Differentially Modulates Phagocytosis and Cytokine Responses during Ingestion of Apoptotic Cells by Human Monocytes, Macrophages, and Dendritic Cells by Fraser, Deborah A, Laust, Amanda K, Nelson, Edward L, Tenner, Andrea J

“…C1q, the first component of the classical complement pathway, is also a pattern recognition receptor involved in the recognition and clearance of apoptotic…”
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Innate immune proteins C1q and mannan-binding lectin enhance clearance of atherogenic lipoproteins by human monocytes and macrophages by Fraser, Deborah A, Tenner, Andrea J

“…Atherosclerosis is a chronic inflammatory disorder that is characterized by the accumulation of modified lipoproteins in the arterial intima. C1q and…”
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Complement Component C1q Mediates Mitochondria-Driven Oxidative Stress in Neonatal Hypoxic-Ischemic Brain Injury by Ten, Vadim S, Yao, Jun, Ratner, Veniamin, Sosunov, Sergey, Fraser, Deborah A, Botto, Marina, Sivasankar, Baalasubramanian, Morgan, B. Paul, Silverstein, Samuel, Stark, Raymond, Polin, Richard, Vannucci, Susan J, Pinsky, David, Starkov, Anatoly A

“…Hypoxic-ischemic (HI) brain injury in infants is a leading cause of lifelong disability. We report a novel pathway mediating oxidative brain injury after…”
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C1q and MBL, components of the innate immune system, influence monocyte cytokine expression by Fraser, Deborah A., Bohlson, Suzanne S., Jasinskiene, Nijole, Rawal, Nenoo, Palmarini, Gail, Ruiz, Sol, Rochford, Rosemary, Tenner, Andrea J.

“…It has recently been recognized that the innate immune response, the powerful first response to infection, has significant influence in determining the nature…”
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Transcriptome data and gene ontology analysis in human macrophages ingesting modified lipoproteins in the presence or absence of complement protein C1q by Ho, Minh-Minh, Fraser, Deborah A.

“…We characterized the transcriptional effects of complement opsonization on foam cell formation in human monocyte-derived macrophages (HMDM). RNA-sequencing was…”
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Complement protein C1q promotes macrophage anti-inflammatory M2-like polarization during the clearance of atherogenic lipoproteins by Spivia, Weston, Magno, Patrick S., Le, Patrick, Fraser, Deborah A.

“…Objective Innate immune protein C1q plays a dual role in the chronic inflammatory disease of atherosclerosis. Complement activation via C1q exacerbates…”
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Complement Protein C1q Enhances Macrophage Foam Cell Survival and Efferocytosis by Pulanco, Marc C, Cosman, Jason, Ho, Minh-Minh, Huynh, Jessica, Fing, Karina, Turcu, Jacqueline, Fraser, Deborah A

“…In the atherosclerotic lesion, macrophages ingest high levels of damaged modified low-density lipoproteins (LDLs), generating macrophage foam cells. Foam cells…”
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Complement, c1q, and c1q-related molecules regulate macrophage polarization by Bohlson, Suzanne S, O'Conner, Sean D, Hulsebus, Holly Jo, Ho, Minh-Minh, Fraser, Deborah A

“…Complement is a critical system of enzymes, regulatory proteins, and receptors that regulates both innate and adaptive immune responses. Natural mutations in…”
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Association between chronic organochlorine exposure and immunotoxicity in the round stingray (Urobatis halleri) by Sawyna, Jillian M., Spivia, Weston R., Radecki, Kelly, Fraser, Deborah A., Lowe, Christopher G.

“…Chronic organochlorine (OC) exposure has been shown to cause immune impairment in numerous vertebrate species. To determine if elasmobranchs exhibited…”
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Recombinant C1q variants modulate macrophage responses but do not activate the classical complement pathway by Espericueta, Victoria, Manughian-Peter, Ayla O., Bally, Isabelle, Thielens, Nicole M., Fraser, Deborah A.

“…Recombinant C1q Variants rC1qB and rC1qC contain mutations in the C1q B-chain (▪ Lys61-Ala) or C-chain (▪ Lys58-Ala) respectively, that render them unable to…”
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Complement proteins C1q and MBL are pattern recognition molecules that signal immediate and long-term protective immune functions by Bohlson, Suzanne S., Fraser, Deborah A., Tenner, Andrea J.

“…C1q and mannose binding lectin, members of the “defense collagen” family, are pattern recognition molecules that can trigger rapid enhanced phagocytosis…”
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Development of a humanized C1q A chain knock-in mouse: Assessment of antibody independent ß-amyloid induced complement activation by Li, Ming, Ager, Rahasson R., Fraser, Deborah A., Tjokro, Natalia O., Tenner, Andrea J.

“…Evidence has been accumulating for a role of inflammation in the development of Alzheimer's disease (AD), a progressive neurodegenerative disorder causing a…”
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Higher Order Architecture of Designer Peptides Forms Bioinspired 10 nm siRNA Delivery System by Gamboa, Alicia, Urfano, Selina F., Hernandez, Katrina, Fraser, Deborah A., Ayalew, Luladey, Slowinska, Katarzyna

“…The higher-order architecture observed in biological systems, like viruses, is very effective in nucleic acid transport. The replications of this system has…”
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Macrophage molecular signaling and inflammatory responses during ingestion of atherogenic lipoproteins are modulated by complement protein C1q by Ho, Minh-Minh, Manughian-Peter, Ayla, Spivia, Weston R, Taylor, Adam, Fraser, Deborah A

“…Abstract Background and aims This study investigated the effect of innate immune protein C1q on macrophage programmed responses during the ingestion of…”
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Complement Activation and Cell Uptake Responses Toward Polymer-Functionalized Protein Nanocapsules by Molino, Nicholas M, Bilotkach, Kateryna, Fraser, Deborah A, Ren, Dongmei, Wang, Szu-Wen

“…Self-assembling protein nanocapsules can be engineered for various bionanotechnology applications. Using the dodecahedral scaffold of the E2 subunit from…”
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Complement protein C1q promotes macrophage anti-inflammatory M2-like polarization during the clearance of atherogenic lipoproteins by Spivia, Weston, Magno, Patrick S., Le, Patrick, Fraser, Deborah A.

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Recombinant Membrane-targeted Form of CD59 Inhibits the Growth of Choroidal Neovascular Complex in Mice by Bora, Nalini S., Jha, Purushottam, Lyzogubov, Valeriy V., Kaliappan, Sankaranarayanan, Liu, Juan, Tytarenko, Ruslana G., Fraser, Deborah A., Morgan, B. Paul, Bora, Puran S.

“…This study was designed to explore the effect of recombinant, membrane-targeted CD59 (rCD59-APT542) on the growth and size of fully developed neovascular…”
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