Search Results - "Fraser, D. A"

The suppression of Antarctic bottom water formation by melting ice shelves in Prydz Bay by Williams, G. D., Herraiz-Borreguero, L., Roquet, F., Tamura, T., Ohshima, K. I., Fukamachi, Y., Fraser, A. D., Gao, L., Chen, H., McMahon, C. R., Harcourt, R., Hindell, M.

“…A fourth production region for the globally important Antarctic bottom water has been attributed to dense shelf water formation in the Cape Darnley Polynya,…”
Get full text

Bathymetric control of warm ocean water access along the East Antarctic Margin by Nitsche, F. O., Porter, D., Williams, G., Cougnon, E. A., Fraser, A. D., Correia, R., Guerrero, R.

“…Observed thinning of the Totten Glacier in East Antarctica has cast doubt upon the stability of the East Antarctic Ice Sheet. Recent oceanographic observations…”
Get full text

Glacier tongue calving reduced dense water formation and enhanced carbon uptake by Shadwick, E. H., Rintoul, S. R., Tilbrook, B., Williams, G. D., Young, N., Fraser, A. D., Marchant, H., Smith, J., Tamura, T.

“…Dense shelf water formed in the Mertz Polynya supplies the lower limb of the global overturning circulation, ventilating the abyssal Indian and Pacific Oceans…”
Get full text

Potential regime shift in decreased sea ice production after the Mertz Glacier calving by Tamura, T., Williams, G.D., Fraser, A.D., Ohshima, K.I.

“…Variability in dense shelf water formation can potentially impact Antarctic Bottom Water (AABW) production, a vital component of the global climate system. In…”
Get full text

Regional Changes in Icescape Impact Shelf Circulation and Basal Melting by Cougnon, E. A., Galton‐Fenzi, B. K., Rintoul, S. R., Legrésy, B., Williams, G. D., Fraser, A. D., Hunter, J. R.

“…Ice shelf basal melt is the dominant contribution to mass loss from Antarctic ice shelves. However, the sensitivity of basal melt to changes in icescape…”
Get full text

A randomised, double blind, placebo controlled, multicentre trial of combination therapy with methotrexate plus ciclosporin in patients with active psoriatic arthritis by Fraser, A D, van Kuijk, A W R, Westhovens, R, Karim, Z, Wakefield, R, Gerards, A H, Landewé, R, Steinfeld, S D, Emery, P, Dijkmans, B A C, Veale, D J

“…Objectives: To evaluate the safety and efficacy of adding ciclosporin A (CSA) to the treatment of patients with psoriatic arthritis (PsA) demonstrating an…”
Get full text

Real life experience confirms sustained response to long-term biologics and switching in ankylosing spondylitis by Coates, L. C., Cawkwell, L. S., Ng, N. W. F., Bennett, A. N., Bryer, D. J., Fraser, A. D., Emery, P., Marzo-Ortega, H.

“…Objective. To investigate the long-term response to biological therapies in AS in a real life clinical setting and to quantify non-response and response to…”
Get full text

Accurate Directional Inference for Vector Parameters in Linear Exponential Families by Davison, A. C., Fraser, D. A. S., Reid, N., Sartori, N.

“…We consider inference on a vector-valued parameter of interest in a linear exponential family, in the presence of a finite-dimensional nuisance parameter…”
Get full text

Physical and Biogeochemical Properties of Rotten East Antarctic Summer Sea Ice by Corkill, M., Moreau, S., Janssens, J., Fraser, A. D., Heil, P., Tison, J.‐L., Cougnon, E. A., Genovese, C., Kimura, N., Meiners, K. M., Wongpan, P., Lannuzel, D.

“…Sea ice forms a barrier to the exchange of energy, gases, moisture and particles between the ocean and atmosphere around Antarctica. Ice temperature, salinity…”
Get full text

Mean loglikelihood and higher-order approximations by Reid, N., Fraser, D. A. S.

“…Higher-order approximations to p-values can be obtained from the loglikelihood function and a reparameterization that can be viewed as a canonical parameter in…”
Get full text

Directing an appropriate immune response: the role of defense collagens and other soluble pattern recognition molecules by Fraser, D A, Tenner, A J

“…Defense collagens and other soluble pattern recognition receptors contain the ability to recognize and bind molecular patterns associated with pathogens…”
Get more information

Sustained response to long-term biologics and switching in psoriatic arthritis: results from real life experience by Coates, L C, Cawkwell, L S, Ng, N W F, Bennett, A N, Bryer, D J, Fraser, A D, Emery, P, Marzo-Ortega, H

“…To investigate the response to biologic drugs in psoriatic arthritis and to quantify non-response and outcome from switching agents. 60 patients (33 men and 27…”
Get more information

Mitochondrial Membrane Potential and Nuclear Changes in Apoptosis Caused by Serum and Nerve Growth Factor Withdrawal: Time Course and Modification by (-)-Deprenyl by Wadia, J. S, Chalmers-Redman, R. M. E, Ju, W. J. H, Carlile, G. W, Phillips, J. L, Fraser, A. D, Tatton, W. G

“…Studies in non-neural cells have suggested that a fall in mitochondrial membrane potential (DeltaPsiM) is one of the earliest events in apoptosis. It is not…”
Get full text

The p-value Function and Statistical Inference by Fraser, D. A. S.

“…This article has two objectives. The first and narrower is to formalize the p-value function, which records all possible p-values, each corresponding to a…”
Get full text

Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations by Fraser, D. A, Hessvik, N. P, Nikolić, N, Aas, V, Hanssen, K. F, Bøhn, S. K, Thoresen, G. H, Rustan, A. C

“…The aim of the present work was to study the effects of benfotiamine (S-benzoylthiamine O-monophosphate) on glucose and lipid metabolism and gene expression in…”
Get full text

Estimating the cost and health status consequences of treatment with TNF antagonists in patients with psoriatic arthritis by Bansback, N. J., Ara, R., Barkham, N., Brennan, A., Fraser, A. D., Conway, P., Reynolds, A., Emery, P.

“…Objectives. Tumour necrosis factor (TNF) has been shown to improve the outcomes in patients with psoriatic arthritis (PsA). We estimate the long-term impact on…”
Get full text

Is Bayes Posterior just Quick and Dirty Confidence? by Fraser, D. A. S.

“…Bayes [Philos. Trans. R. Soc. Lond. 53 (1763) 370—418; 54 296—325] introduced the observed likelihood function to statistical inference and provided a weight…”
Get full text

Triglycerides-diabetes association in healthy middle-aged men: modified by physical fitness? A long term follow-up of 1962 Norwegian men in the Oslo Ischemia Study by Skretteberg, P T, Grytten, A N, Gjertsen, K, Grundvold, I, Kjeldsen, S E, Erikssen, J, Mellbin, L, Liestøl, K, Fraser, D A, Erikssen, G, Pedersen, T R, Bodegard, J

“…To examine the impact of physical fitness (PF) on the association between fasting serum triglycerides (FTG) and diabetes risk and whether temporal changes in…”
Get full text

The linear Lasso: A location model approach by Fraser, D. A. S., Bédard, Mylène

“…We use location model methodology to guide the least squares analysis in the Lasso problem of variable selection and inference. The nuisance parameter is taken…”
Get full text

Improved likelihood inference for discrete data by Davison, A. C., Fraser, D. A. S., Reid, N.

“…Discrete data, particularly count and contingency table data, are typically analysed by using methods that are accurate to first order, such as normal…”
Get full text