Search Results - "Fraser, Craig"

Development and Bioorthogonal Activation of Palladium-Labile Prodrugs of Gemcitabine by Weiss, Jason T, Dawson, John C, Fraser, Craig, Rybski, Witold, Torres-Sánchez, Carmen, Bradley, Mark, Patton, E. Elizabeth, Carragher, Neil O, Unciti-Broceta, Asier

“…Bioorthogonal chemistry has become one of the main driving forces in current chemical biology, inspiring the search for novel biocompatible chemospecific…”
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Stable Carbocation Generated via 2,5-Cyclohexadien-1-one Protonation by Fraser, Craig, Young, Rowan D

“…Protonation of a substituted cyclohexadien-1-one (1) leads to the generation of carbocation [3]+, capable of effecting hydride abstraction and oxidation…”
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Jeremy Gray. The Real and the Complex: A History of Analysis in the Nineteenth Century . (Springer Undergraduate Mathematics Series.) xvi + 350 pp., figs., illus., apps., bibl., index. Cham, Switzerland: Springer, 2015. €36 (paper) by Fraser, Craig

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Awarding of the May Prizes for 2017 by Fraser, Craig

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Canonical transformations from Jacobi to Whittaker by Fraser, Craig, Nakane, Michiyo

“…The idea of a canonical transformation emerged in 1837 in the course of Carl Jacobi's researches in analytical dynamics. To understand Jacobi's moment of…”
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Suzanne Féry (Editor). Aventures de l'analyse de Fermat à Borel: Mélanges en l'honneur de Christian Gilain . (Histoires de Géométries.) 728 pp., illus., bibl., index. Nancy: Presses Universitaires de Nancy, 2012. €30 (paper) by Fraser, Craig

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Martin Harwit. In Search of the True Universe: The Tools, Shaping, and Cost of Cosmological Thought . xvii + 393 pp., illus., tables, apps., index. Cambridge: Cambridge University Press, 2013. $50 (cloth) by Fraser, Craig

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Roger Hahn (Editor). Correspondance de Pierre Simon Laplace (1749–1827) . Volumes 1 and 2. xiv + 1,416 pp., illus., tables, index. Turnhout: Brepols Publishers, 2012. €120 (cloth) by Fraser, Craig

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Mild FVII deficiency – Correlation between genotype and phenotype by Fraser, Craig, Watson, Henry G., Khan, Mohammed M.

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Extracellular palladium-catalysed dealkylation of 5-fluoro-1-propargyl-uracil as a bioorthogonally activated prodrug approach by Weiss, Jason T., Dawson, John C., Macleod, Kenneth G., Rybski, Witold, Fraser, Craig, Torres-Sánchez, Carmen, Patton, E. Elizabeth, Bradley, Mark, Carragher, Neil O., Unciti-Broceta, Asier

“…A bioorthogonal organometallic reaction is a biocompatible transformation undergone by a synthetic material exclusively through the mediation of a non-biotic…”
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Alkali Metal Adducts of an Iron(0) Complex and Their Synergistic FLP-Type Activation of Aliphatic C–X Bonds by Tinnermann, Hendrik, Sung, Simon, Csókás, Dániel, Toh, Zhi Hao, Fraser, Craig, Young, Rowan D

“…We report the formation and full characterization of weak adducts between Li+ and Na+ cations and a neutral iron(0) complex, [Fe­(CO)3(PMe3)2] (1), supported…”
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The early history of Hamilton-Jacobi dynamics 1834-1837 by Nakane, Michiyo, Fraser, Craig G

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Pyrazolopyrimide library screening in glioma cells discovers highly potent antiproliferative leads that target the PI3K/mTOR pathway by Valero, Teresa, Baillache, Daniel J., Fraser, Craig, Myers, Samuel H., Unciti-Broceta, Asier

“…[Display omitted] The search for novel targeted inhibitors active on glioblastoma multiforme is crucial to develop new treatments for this unmet clinical need…”
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Awarding of the May Prizes for 2013 by Fraser, Craig

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Barbara J. Becker. Unravelling Starlight: William and Margaret Huggins and the Rise of the New Astronomy . xix + 380 pp., illus., bibl., index. Cambridge/New York: Cambridge University Press, 2011. $110 (cloth) by Fraser, Craig

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A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability by Temps, Carolin, Lietha, Daniel, Webb, Emily R, Li, Xue-Feng, Dawson, John C, Muir, Morwenna, Macleod, Kenneth G, Valero, Teresa, Munro, Alison F, Contreras-Montoya, Rafael, Luque-Ortega, Juan R, Fraser, Craig, Beetham, Henry, Schoenherr, Christina, Lopalco, Maria, Arends, Mark J, Frame, Margaret C, Qian, Bin-Zhi, Brunton, Valerie G, Carragher, Neil O, Unciti-Broceta, Asier

“…Despite the approval of several multikinase inhibitors that target SRC and the overwhelming evidence of the role of SRC in the progression and resistance…”
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Rapid Discovery and Structure–Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase by Fraser, Craig, Dawson, John C, Dowling, Reece, Houston, Douglas R, Weiss, Jason T, Munro, Alison F, Muir, Morwenna, Harrington, Lea, Webster, Scott P, Frame, Margaret C, Brunton, Valerie G, Patton, E. Elizabeth, Carragher, Neil O, Unciti-Broceta, Asier

“…Novel pyrazolopyrimidines displaying high potency and selectivity toward SRC family kinases have been developed by combining ligand-based design and phenotypic…”
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Sublingual immunotherapy vs placebo in the management of grass pollen‐induced allergic rhinitis in adults: A systematic review and meta‐analysis by Boldovjáková, Dominika, Cordoni, Sara, Fraser, Craig John, Love, Aimee Beth, Patrick, Lorna, Ramsay, Gary James, Ferguson, Aaron Stephen James, Gomati, Anas, Ram, Bhaskar

“…Introduction Allergic rhinitis (AR) is a common inflammatory condition of the nasal mucosa affecting approximately 20% of the population worldwide. Current…”
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A novel mode of inhibiting SRC improves drug efficacy and tolerability by Temps, Carolin, Lietha, Daniel, Webb, Emily R., Li, Xue-Feng, Dawson, John C., Muir, Morwenna, Macleod, Kenneth G., Valero, Teresa, Munro, Alison F., Contreras-Montoya, Rafael, Luque-Ortega, Juan R., Fraser, Craig, Beetham, Henry, Schoenherr, Christina, Lopalco, Maria, Arends, Mark J., Frame, Margaret C., Qian, Bin-Zhi, Brunton, Valerie G., Carragher, Neil O., Unciti-Broceta, Asier

“…Despite the approval of several multikinase inhibitors that target SRC and the overwhelming evidence of the role of SRC in the progression and resistance…”
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Ursula Goldenbaum;, Douglas Jesseph (Editors). Infinitesimal Differences: Controversies between Leibniz and His Contemporaries . vi + 327 pp., bibl., index. Berlin/New York: Walter de Gruyter, 2008. €72.90 (cloth) by Fraser, Craig

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