Search Results - "Fraschka, Sabine"

GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependent gene silencing by Filarsky, Michael, Fraschka, Sabine A, Niederwieser, Igor, Brancucci, Nicolas M B, Carrington, Eilidh, Carrió, Elvira, Moes, Suzette, Jenoe, Paul, Bártfai, Richárd, Voss, Till S

“…Malaria is caused by parasites that proliferate in the bloodstream. During each replication cycle, some parasites differentiate into gametocytes, the only…”
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Chromatin Accessibility-Based Characterization of the Gene Regulatory Network Underlying Plasmodium falciparum Blood-Stage Development by Toenhake, Christa Geeke, Fraschka, Sabine Anne-Kristin, Vijayabaskar, Mahalingam Shanmugiah, Westhead, David Robert, van Heeringen, Simon Jan, Bártfai, Richárd

“…Underlying the development of malaria parasites within erythrocytes and the resulting pathogenicity is a hardwired program that secures proper timing of gene…”
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Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer’s disease-like pathology in human cerebral organoids by Pérez, María José, Ivanyuk, Dina, Panagiotakopoulou, Vasiliki, Di Napoli, Gabriele, Kalb, Stefanie, Brunetti, Dario, Al-Shaana, Rawaa, Kaeser, Stephan A., Fraschka, Sabine Anne-Kristin, Jucker, Mathias, Zeviani, Massimo, Viscomi, Carlo, Deleidi, Michela

“…s Mutations in pitrilysin metallopeptidase 1 (PITRM1), a mitochondrial protease involved in mitochondrial precursor processing and degradation, result in a…”
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An epigenetic map of malaria parasite development from host to vector by Witmer, Kathrin, Fraschka, Sabine A., Vlachou, Dina, Bártfai, Richárd, Christophides, George K.

“…The malaria parasite replicates asexually in the red blood cells of its vertebrate host employing epigenetic mechanisms to regulate gene expression in response…”
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SARS‐CoV‐2‐reactive T‐cell receptors isolated from convalescent COVID‐19 patients confer potent T‐cell effector function by Brunk, Fabian, Moritz, Andreas, Nelde, Annika, Bilich, Tatjana, Casadei, Nicolas, Fraschka, Sabine A. K., Heitmann, Jonas S., Hörber, Sebastian, Peter, Andreas, Rammensee, Hans‐Georg, Singh, Harpreet, Walz, Juliane, Maurer, Dominik, Wagner, Claudia

“…Both B cells and T cells are involved in an effective immune response to SARS‐CoV‐2, the disease‐causing virus of COVID‐19. While B cells—with the…”
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Comparative Heterochromatin Profiling Reveals Conserved and Unique Epigenome Signatures Linked to Adaptation and Development of Malaria Parasites by Fraschka, Sabine A., Filarsky, Michael, Hoo, Regina, Niederwieser, Igor, Yam, Xue Yan, Brancucci, Nicolas M.B., Mohring, Franziska, Mushunje, Annals T., Huang, Ximei, Christensen, Peter R., Nosten, Francois, Bozdech, Zbynek, Russell, Bruce, Moon, Robert W., Marti, Matthias, Preiser, Peter R., Bártfai, Richárd, Voss, Till S.

“…Heterochromatin-dependent gene silencing is central to the adaptation and survival of Plasmodium falciparum malaria parasites, allowing clonally variant gene…”
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H3.3 demarcates GC-rich coding and subtelomeric regions and serves as potential memory mark for virulence gene expression in Plasmodium falciparum by Fraschka, Sabine Anne-Kristin, Henderson, Rob Wilhelmus Maria, Bártfai, Richárd

“…Histones, by packaging and organizing the DNA into chromatin, serve as essential building blocks for eukaryotic life. The basic structure of the chromatin is…”
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Gene knockdown in malaria parasites via non-canonical RNAi by Hentzschel, Franziska, Mitesser, Vera, Fraschka, Sabine Anne-Kristin, Krzikalla, Daria, Carrillo, Elena Herrera, Berkhout, Ben, Bártfai, Richárd, Mueller, Ann-Kristin, Grimm, Dirk

“…Abstract The lack of endogenous RNAi machinery in the malaria parasite Plasmodium hampers gene annotation and hence antimalarial drug and vaccine development…”
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Using Transcriptomic Analysis to Assess Double-Strand Break Repair Activity: Towards Precise in vivo Genome Editing by Pasquini, Giovanni, Cora, Virginia, Swiersy, Anka, Achberger, Kevin, Antkowiak, Lena, Müller, Brigitte, Wimmer, Tobias, Fraschka, Sabine Anne-Kristin, Casadei, Nicolas, Ueffing, Marius, Liebau, Stefan, Stieger, Knut, Busskamp, Volker

“…Mutations in more than 200 retina-specific genes have been associated with inherited retinal diseases. Genome editing represents a promising emerging field in…”
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The neural crest transcription factor Brn3a is expressed in melanoma and required for cell cycle progression and survival by Hohenauer, Tobias, Berking, Carola, Schmidt, Andreas, Haferkamp, Sebastian, Senft, Daniela, Kammerbauer, Claudia, Fraschka, Sabine, Graf, Saskia Anna, Irmler, Martin, Beckers, Johannes, Flaig, Michael, Aigner, Achim, Höbel, Sabrina, Hoffmann, Franziska, Hermeking, Heiko, Rothenfusser, Simon, Endres, Stefan, Ruzicka, Thomas, Besch, Robert

“…Pigment cells and neuronal cells both are derived from the neural crest. Here, we describe the Pit‐Oct‐Unc (POU) domain transcription factor Brn3a, normally…”
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