Search Results - "Frasch, Alberto C C"

Trypanosoma cruzi surface mucins: host-dependent coat diversity by Buscaglia, Carlos A, Di Noia, Javier M, Campo, Vanina A, Frasch, Alberto C. C

“…The surface of the protozoan parasite Trypanosoma cruzi is covered in mucins, which contribute to parasite protection and to the establishment of a persistent…”
Get full text

Neuronal filopodium formation induced by the membrane glycoprotein M6a (Gpm6a) is facilitated by coronin‐1a, Rac1, and p21‐activated kinase 1 (Pak1) by Alvarez Juliá, Anabel, Frasch, Alberto C., Fuchsova, Beata

“…Stress‐responsive neuronal membrane glycoprotein M6a (Gpm6a) functions in neurite extension, filopodium and spine formation and synaptogenesis. The mechanisms…”
Get full text

An RNA Recognition Motif Mediates the Nucleocytoplasmic Transport of a Trypanosome RNA-binding Protein by Cassola, Alejandro, Frasch, Alberto C.

“…RNA-binding proteins (RBPs) and RNA metabolism are considered to be important for modulating gene expression in trypanosomes, because these protozoan parasites…”
Get full text

Evaluation of a Recombinant Trypanosoma cruzi Mucin-Like Antigen for Serodiagnosis of Chagas' Disease by De Marchi, Claudia R, Di Noia, Javier M, Frasch, Alberto C C, Amato Neto, Vicente, Almeida, Igor C, Buscaglia, Carlos A

“…Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Filopodia formation driven by membrane glycoprotein M6a depends on the interaction of its transmembrane domains by Formoso, Karina, García, Micaela D., Frasch, Alberto C., Scorticati, Camila

“…Membrane glycoprotein M6a, which belongs to the tetraspan proteolipid protein family, promotes structural plasticity in neurons and cell lines by unknown…”
Get full text

Identification of Potential Interacting Proteins With the Extracellular Loops of the Neuronal Glycoprotein M6a by TMT/MS by Aparicio, Gabriela I., Formoso, Karina, León, Antonella, Frasch, Alberto C., Scorticati, Camila

“…Nowadays, great efforts are made to gain insight into the molecular mechanisms that underlie structural neuronal plasticity. Moreover, the identification of…”
Get full text

Gene expression regulation in trypanosomatids by De Gaudenzi, Javier G, Noé, Griselda, Campo, Vanina A, Frasch, Alberto C, Cassola, Alejandro

“…Trypanosomatids are protozoan micro-organisms that cause serious health problems in humans and domestic animals. In addition to their medical relevance, these…”
Get more information

Regulation of Hippocampal Gene Expression Is Conserved in Two Species Subjected to Different Stressors and Antidepressant Treatments by Alfonso, Julieta, Frick, Luciana R., Silberman, Dafne M., Palumbo, María L., Genaro, Ana M., Frasch, Alberto C.

“…Chronic stress has significant effects on hippocampal structure and function. We have previously identified nerve growth factor (NGF), membrane glycoprotein 6a…”
Get full text

RNA-Binding Domain Proteins in Kinetoplastids: a Comparative Analysis by De Gaudenzi, Javier, Frasch, Alberto C, Clayton, Christine

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Filopodial protrusions induced by glycoprotein M6a exhibit high motility and aids synapse formation by Brocco, Marcela A., Fernández, María Eugenia, Frasch, Alberto C. C.

“…M6a is a neuronal membrane glycoprotein whose expression diminishes during chronic stress. M6a overexpression in rat primary hippocampal neurons induces the…”
Get full text

The Stress-Regulated Protein M6a Is a Key Modulator for Neurite Outgrowth and Filopodium/Spine Formation by Julieta Alfonso, María E. Fernández, Benjamin Cooper, Flugge, Gabriele, Alberto C. Frasch

“…Neuronal remodeling is a fundamental process by which the brain responds to environmental influences, e.g., during stress. In the hippocampus, chronic stress…”
Get full text

Alanine Scanning Mutagenesis of the C-Terminal Cytosolic End of Gpm6a Identifies Key Residues Essential for the Formation of Filopodia by Rosas, Nicolás M, Alvarez Juliá, Anabel, Alzuri, Sofia E, Frasch, Alberto C, Fuchsova, Beata

“…Neuronal membrane glycoprotein M6a (Gpm6a) is a protein with four transmembrane regions and the N- and the C-ends facing the cytosol. It functions in processes…”
Get full text

Trypanosoma cruzi Trans-sialidase Operates through a Covalent Sialyl−Enzyme Intermediate:  Tyrosine Is the Catalytic Nucleophile by WATTS, Andrew G., DAMAGER, Iben, AMAYA, Maria L., BUSCHIAZZO, Alejandro, ALZARI, Pedro, FRASCH, Alberto C., WITHERS, Stephen G.

“…Modified sialic acid substrates have been used to label Trypanosoma cruzi trans-sialidase, demonstrating that the enzyme catalyses the transfer of sialic acid…”
Get full text

Cysteine Residues in the Large Extracellular Loop (EC2) Are Essential for the Function of the Stress-regulated Glycoprotein M6a by Fuchsova, Beata, Fernández, María E., Alfonso, Julieta, Frasch, Alberto C.

“…Gpm6a was identified as a stress-responsive gene in the hippocampal formation. This gene is down-regulated in the hippocampus of both socially and physically…”
Get full text

Synthesis of PEGylated lactose analogs for inhibition studies on T.cruzi trans-sialidase by Giorgi, M. Eugenia, Ratier, Laura, Agusti, Rosalía, Frasch, Alberto C. C, de Lederkremer, Rosa M

“…Trypanosoma cruzi, the agent of Chagas disease, expresses a unique enzyme, the trans-sialidase (TcTS) involved in the transfer of sialic acid from host…”
Get full text

RNA recognition motifs involved in nuclear import of RNA-binding proteins by Cassola, Alejandro, Noé, Griselda, Frasch, Alberto C.

“…In eukaryotic cells, a regulated import and export of factors is required to fulfill the requirements of precise gene expression. Post-transcriptional…”
Get full text

Genome-wide analysis of 3'-untranslated regions supports the existence of post-transcriptional regulons controlling gene expression in trypanosomes by De Gaudenzi, Javier G, Carmona, Santiago J, Agüero, Fernán, Frasch, Alberto C

“…In eukaryotic cells, a group of messenger ribonucleic acids (mRNAs) encoding functionally interrelated proteins together with the trans-acting factors that…”
Get full text

Conserved cellular function and stress-mediated regulation among members of the proteolipid protein family by Fernández, María E., Alfonso, Julieta, Brocco, Marcela A., Frasch, Alberto C.

“…Chronic stress causes morphological alterations in the hippocampus of rodents and tree shrews, including atrophy of CA3 dendrites and loss of synapses. The…”
Get full text

The Membrane Glycoprotein M6a Endocytic/Recycling Pathway Involves Clathrin-Mediated Endocytosis and Affects Neuronal Synapses by Garcia, Micaela D, Formoso, Karina, Aparicio, Gabriela I, Frasch, Alberto C C, Scorticati, Camila

“…Single point mutations or variations in the expression of the gene encoding the neuronal glycoprotein M6a have been associated with psychiatric disorders such…”
Get full text

M6 membrane protein plays an essential role in Drosophila oogenesis by Zappia, María Paula, Brocco, Marcela Adriana, Billi, Silvia C, Frasch, Alberto C, Ceriani, María Fernanda

“…We had previously shown that the transmembrane glycoprotein M6a, a member of the proteolipid protein (PLP) family, regulates neurite/filopodium outgrowth,…”
Get full text