Several Nocardia abcessus bronchiolitis in a patient treated with inhaled corticosteroids: a case report

Several Nocardia abcessus bronchiolitis in a patient treated with inhaled corticosteroids: a case report

Nocardiosis is a disease that mainly affects immunocompromised patients. Inhaled corticosteroids (ICS) are standard of care for asthma. This treatment can induce respiratory infections but no case of bronchiolitis nocardiosis have been described so far. A 58-year-old man, with history of controlled...

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Bibliographic Details
Published in:Allergy, asthma, and clinical immunology Vol. 19; no. 1; p. 27
Main Authors: Cascarano, Estelle, Frappa, Murielle, Degano, Bruno, Pelloux, Isabelle, Saint-Raymond, Christel, Gheerbrant, Hubert
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 03-04-2023
BioMed Central
BMC
Subjects:
Antibiotics
Asthma
Bronchiolitis
Case Report
Case reports
Chronic illnesses
Chronic obstructive pulmonary disease
Corticosteroids
Drug therapy
Dyspnea
Exercise
Health aspects
Immunocompetence
Infection
Infections
Inhaled corticosteroids
Lung diseases
Medical imaging
Nocardiosis
Patients
Pneumonia
Pulmonary function tests
Serology
Steroids
Nocardiosis
Case report
Inhaled corticosteroids
Asthma
Bronchiolitis
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Summary:Nocardiosis is a disease that mainly affects immunocompromised patients. Inhaled corticosteroids (ICS) are standard of care for asthma. This treatment can induce respiratory infections but no case of bronchiolitis nocardiosis have been described so far. A 58-year-old man, with history of controlled moderate allergic asthma, develop an increased cought in the last two years associated with dyspnea on exertion. Within two months, although ICS were increased to high doses, symptoms worsened due to a severe obstructive ventilatory disorder as revealed by pulmonary function tests (PFT). Small-scale lesions (< 10%) were found on chest computed tomography (CT). A bronchoalveolar lavage (BAL) found Nocardia abcessus. After six months of Sulfamethoxazole/Trimethoprim, PFT results improved and chest CT became completely normal. We therefore present the case of a bronchiolitis nocardiosis with several bronchial syndrome and the only immunosuppressive factor found were ICS.
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ISSN:1710-1484
1710-1492
1710-1492
DOI:10.1186/s13223-023-00779-2