Search Results - "Franzoso, Guido"

Life, death, and autophagy in cancer: NF-κB turns up everywhere by Verzella, Daniela, Pescatore, Alessandra, Capece, Daria, Vecchiotti, Davide, Ursini, Matilde Valeria, Franzoso, Guido, Alesse, Edoardo, Zazzeroni, Francesca

“…Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key regulator of cell survival and aberrant NF-κB signaling has been…”
Get full text

Rewired lipid metabolism as an actionable vulnerability of aggressive colorectal carcinoma by Capece, Daria, Franzoso, Guido

“…Cancer cells reprogram lipid metabolism to fuel cell division, adaptation to stress, and metastatic dissemination. NF-κB transcription factors control this…”
Get full text

Programmed necrosis induced by asbestos in human mesothelial cells causes high-mobility group box 1 protein release and resultant inflammation by Yang, Haining, Rivera, Zeyana, Jube, Sandro, Nasu, Masaki, Bertino, Pietro, Goparaju, Chandra, Franzoso, Guido, Lotze, Michael T., Krausz, Thomas, Pass, Harvey I., Bianchi, Marco E., Carbone, Michele, Rowley, Janet D.

“…Asbestos carcinogenesis has been linked to the release of cytokines and mutagenic reactive oxygen species (ROS) from inflammatory cells. Asbestos is cytotoxic…”
Get full text

GADD45β Loss Ablates Innate Immunosuppression in Cancer by Verzella, Daniela, Bennett, Jason, Fischietti, Mariafausta, Thotakura, Anil K, Recordati, Camilla, Pasqualini, Fabio, Capece, Daria, Vecchiotti, Davide, D'Andrea, Daniel, Di Francesco, Barbara, De Maglie, Marcella, Begalli, Federica, Tornatore, Laura, Papa, Salvatore, Lawrence, Toby, Forbes, Stuart J, Sica, Antonio, Alesse, Edoardo, Zazzeroni, Francesca, Franzoso, Guido

“…T-cell exclusion from the tumor microenvironment (TME) is a major barrier to overcoming immune escape. Here, we identify a myeloid-intrinsic mechanism governed…”
Get full text

TNF-α Inhibits Asbestos-Induced Cytotoxicity via a NF-κB-Dependent Pathway, a Possible Mechanism for Asbestos-Induced Oncogenesis by Yang, Haining, Bocchetta, Maurizio, Kroczynska, Barbara, Elmishad, Amira G., Chen, Yuanbin, Liu, Zemin, Bubici, Concetta, Mossman, Brooke T., Pass, Harvey I., Testa, Joseph R., Franzoso, Guido, Carbone, Michele

“…Asbestos is the main cause of human malignant mesothelioma (MM). In vivo, macrophages phagocytize asbestos and, in response, release TNF-α and other cytokines…”
Get full text

The NF-κB Pharmacopeia: Novel Strategies to Subdue an Intractable Target by Verzella, Daniela, Cornice, Jessica, Arboretto, Paola, Vecchiotti, Davide, Di Vito Nolfi, Mauro, Capece, Daria, Zazzeroni, Francesca, Franzoso, Guido

“…NF-κB transcription factors are major drivers of tumor initiation and progression. NF-κB signaling is constitutively activated by genetic alterations or…”
Get full text

Upregulation of Twist-1 by NF-κB Blocks Cytotoxicity Induced by Chemotherapeutic Drugs by Pham, Can G., Bubici, Concetta, Zazzeroni, Francesca, Knabb, James R., Papa, Salvatore, Kuntzen, Christian, Franzoso, Guido

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Unlocking the NF-κB Conundrum: Embracing Complexity to Achieve Specificity by Begalli, Federica, Bennett, Jason, Capece, Daria, Verzella, Daniela, D'Andrea, Daniel, Tornatore, Laura, Franzoso, Guido

“…Transcription factors of the nuclear factor κB (NF-κB) family are central coordinating regulators of the host defence responses to stress, injury and…”
Get full text

CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells by Barnhart, Bryan C, Legembre, Patrick, Pietras, Eric, Bubici, Concetta, Franzoso, Guido, Peter, Marcus E

“…The apoptosis‐inducing death receptor CD95 (APO‐1/Fas) controls the homeostasis of many tissues. Despite its apoptotic potential, most human tumors are…”
Get full text

Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance by Ma, Liang, Mauro, Claudio, Cornish, Georgina H., Chai, Jian-Guo, Coe, David, Fu, Hongmei, Patton, Daniel, Okkenhaug, Klaus, Franzoso, Guido, Dyson, Julian, Nourshargh, Sussan, Marelli-Berg, Federica M., Mitchison, N. Avrion

“…CD31 is an Ig-like molecule expressed by leukocytes and endothelial cells with an established role in the regulation of leukocyte trafficking. Despite genetic…”
Get full text

Insights into the Interaction Mechanism of DTP3 with MKK7 by Using STD-NMR and Computational Approaches by Sandomenico, Annamaria, Di Rienzo, Lorenzo, Calvanese, Luisa, Iaccarino, Emanuela, D'Auria, Gabriella, Falcigno, Lucia, Chambery, Angela, Russo, Rosita, Franzoso, Guido, Tornatore, Laura, D'Abramo, Marco, Ruvo, Menotti, Milanetti, Edoardo, Raimondo, Domenico

“…GADD45β/MKK7 complex is a non-redundant, cancer cell-restricted survival module downstream of the NF-kB survival pathway, and it has a pathogenically critical…”
Get full text

NF-κB and JNK: An Intricate Affair by Bubici, Concetta, Papa, Salvatore, Pham, Can G., Zazzeroni, Francesca, Franzoso, Guido

“…NF-κB/Rel transcription factors block apoptosis or programmed cell death (PCD)induced by tumor necrosis factor (TNF)α. The antiapoptotic activity of NF-κB is…”
Get full text

Preclinical toxicology and safety pharmacology of the first-in-class GADD45β/MKK7 inhibitor and clinical candidate, DTP3 by Tornatore, Laura, Capece, Daria, D'Andrea, Daniel, Begalli, Federica, Verzella, Daniela, Bennett, Jason, Acton, Gary, Campbell, Elizabeth A., Kelly, James, Tarbit, Michael, Adams, Nigel, Bannoo, Selina, Leonardi, Antonio, Sandomenico, Annamaria, Raimondo, Domenico, Ruvo, Menotti, Chambery, Angela, Oblak, Metod, Al-Obaidi, Magda J., Kaczmarski, Richard S., Gabriel, Ian, Oakervee, Heather E., Kaiser, Martin F., Wechalekar, Ashutosh, Benjamin, Reuben, Apperley, Jane F., Auner, Holger W., Franzoso, Guido

“…[Display omitted] •DTP3 eliminates any viable MM cells in mice upon i.v. bolus administration.•DTP3 exhibits highly favourable PK and ADME profiles, with long…”
Get full text

Growth arrest and DNA damage protein 45b (Gadd45b) protects retinal ganglion cells from injuries by Liu, Bin, Suyeoka, Genn, Papa, Salvatore, Franzoso, Guido, Neufeld, Arthur H

“…Abstract We hypothesize that neurons have protective mechanisms against adverse local conditions that improve the chances of cell survival. In the present…”
Get full text

Physical and Functional Interaction of Filamin (Actin-binding Protein-280) and Tumor Necrosis Factor Receptor-associated Factor 2 by Leonardi, A, Ellinger-Ziegelbauer, H, Franzoso, G, Brown, K, Siebenlist, U

“…Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) is an intracellular protein involved in signal transduction from TNF receptor I and II and…”
Get full text

NF-κB: blending metabolism, immunity, and inflammation by Capece, Daria, Verzella, Daniela, Flati, Irene, Arboretto, Paola, Cornice, Jessica, Franzoso, Guido

“…The procurement and management of nutrients and ability to fight infections are fundamental requirements for survival. These defense responses are…”
Get full text

The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation by Tornatore, Laura, Thotakura, Anil K, Bennett, Jason, Moretti, Marta, Franzoso, Guido

“…Nuclear factor kappa B (NF-κB) transcription factors are evolutionarily conserved, coordinating regulators of immune and inflammatory responses. They also play…”
Get full text

NF-κB and mitochondria cross paths in cancer: mitochondrial metabolism and beyond by Capece, Daria, Verzella, Daniela, Di Francesco, Barbara, Alesse, Edoardo, Franzoso, Guido, Zazzeroni, Francesca

“…•NF-κB governs energy homeostasis and promotes metabolic adaptation of cancer cells.•Metabolic alteration and mitochondria have been recognised as key players…”
Get full text

NF-κB in the crosshairs: Rethinking an old riddle by Bennett, Jason, Capece, Daria, Begalli, Federica, Verzella, Daniela, D’Andrea, Daniel, Tornatore, Laura, Franzoso, Guido

“…•NF-κB transcription factors are central coordinating regulators of immunity, inflammation and cell survival.•NF-κB pathway is aberrantly and stably activated…”
Get full text

NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration by Franzoso, Guido, Mauro, Claudio, Leow, Shi Chi, Anso, Elena, Rocha, Sonia, Thotakura, Anil K, Tornatore, Laura, Moretti, Marta, De Smaele, Enrico, Beg, Amer A, Tergaonkar, Vinay, Chandel, Navdeep S

“…Cell proliferation is a metabolically demanding process. It requires active reprogramming of cellular bioenergetic pathways towards glucose metabolism to…”
Get full text