Search Results - "Franzolin, Elisa"

deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells by Franzolin, Elisa, Pontarin, Giovanna, Rampazzo, Chiara, Miazzi, Cristina, Ferraro, Paola, Palumbo, Elisa, Reichard, Peter, Bianchi, Vera

“…Sterile alpha motif and HD-domain containing protein 1 (SAMHD1) is a triphosphohydrolase converting deoxynucleoside triphosphates (dNTPs) to deoxynucleosides…”
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Quantitation of cellular deoxynucleoside triphosphates by Ferraro, Paola, Franzolin, Elisa, Pontarin, Giovanna, Reichard, Peter, Bianchi, Vera

“…Eukaryotic cells contain a delicate balance of minute amounts of the four deoxyribonucleoside triphosphates (dNTPs), sufficient only for a few minutes of DNA…”
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Synthesis of Mitochondrial DNA Precursors during Myogenesis, an Analysis in Purified C2C12 Myotubes [S] by Frangini, Miriam, Franzolin, Elisa, Chemello, Francesco, Laveder, Paolo, Romualdi, Chiara, Bianchi, Vera, Rampazzo, Chiara

“…During myogenesis, myoblasts fuse into multinucleated myotubes that acquire the contractile fibrils and accessory structures typical of striated skeletal…”
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Mitochondrial Thymidine Kinase and the Enzymatic Network Regulating Thymidine Triphosphate Pools in Cultured Human Cells by Rampazzo, Chiara, Fabris, Sonia, Franzolin, Elisa, Crovatto, Katia, Frangini, Miriam, Bianchi, Vera

“…In non-proliferating cells mitochondrial (mt) thymidine kinase (TK2) salvages thymidine derived from the extracellular milieu for the synthesis of mt dTTP. TK2…”
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dNTP metabolism links mechanical cues and YAP/TAZ to cell growth and oncogene‐induced senescence by Santinon, Giulia, Brian, Irene, Pocaterra, Arianna, Romani, Patrizia, Franzolin, Elisa, Rampazzo, Chiara, Bicciato, Silvio, Dupont, Sirio

“…YAP/TAZ, downstream transducers of the Hippo pathway, are powerful regulators of cancer growth. How these factors control proliferation remains poorly defined…”
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The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase by Franzolin, Elisa, Salata, Cristiano, Bianchi, Vera, Rampazzo, Chiara

“…The dNTP triphosphohydrolase SAMHD1 is a nuclear antiviral host restriction factor limiting HIV-1 infection in macrophages and a major regulator of dNTP…”
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Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances by Rampazzo, Chiara, Miazzi, Cristina, Franzolin, Elisa, Pontarin, Giovanna, Ferraro, Paola, Frangini, Miriam, Reichard, Peter, Bianchi, Vera

“…Deoxyribonucleoside triphosphates (dNTPs) are the precursors used by DNA polymerases for replication and repair of nuclear and mitochondrial DNA in animal…”
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SAMHD1‐deficient fibroblasts from Aicardi‐Goutières Syndrome patients can escape senescence and accumulate mutations by Franzolin, Elisa, Coletta, Sara, Ferraro, Paola, Pontarin, Giovanna, D'Aronco, Giulia, Stevanoni, Martina, Palumbo, Elisa, Cagnin, Stefano, Bertoldi, Loris, Feltrin, Erika, Valle, Giorgio, Russo, Antonella, Bianchi, Vera, Rampazzo, Chiara

“…In mammalian cells, the catabolic activity of the dNTP triphosphohydrolase SAMHD1 sets the balance and concentration of the four dNTPs. Deficiency of SAMHD1…”
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d NTP metabolism links mechanical cues and YAP / TAZ to cell growth and oncogene‐induced senescence by Santinon, Giulia, Brian, Irene, Pocaterra, Arianna, Romani, Patrizia, Franzolin, Elisa, Rampazzo, Chiara, Bicciato, Silvio, Dupont, Sirio

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A defective dNTP pool hinders DNA replication in cell cycle-reactivated terminally differentiated muscle cells by Pajalunga, Deborah, Franzolin, Elisa, Stevanoni, Martina, Zribi, Sara, Passaro, Nunzia, Gurtner, Aymone, Donsante, Samantha, Loffredo, Daniela, Losanno, Lidia, Bianchi, Vera, Russo, Antonella, Rampazzo, Chiara, Crescenzi, Marco

“…Terminally differentiated cells are defined by their inability to proliferate. When forced to re-enter the cell cycle, they generally cannot undergo long-term…”
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Enhanced Silkworm Cecropin B Antimicrobial Activity against Pseudomonas aeruginosa from Single Amino Acid Variation by Romoli, Ottavia, Mukherjee, Shruti, Mohid, Sk Abdul, Dutta, Arkajyoti, Montali, Aurora, Franzolin, Elisa, Brady, Daniel, Zito, Francesca, Bergantino, Elisabetta, Rampazzo, Chiara, Tettamanti, Gianluca, Bhunia, Anirban, Sandrelli, Federica

“…Pseudomonas aeruginosa is an opportunistic bacterial pathogen causing severe infections in hospitalized and immunosuppressed patients, particularly individuals…”
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The pyrimidine nucleotide carrier PNC1 and mitochondrial trafficking of thymidine phosphates in cultured human cells by Franzolin, Elisa, Miazzi, Cristina, Frangini, Miriam, Palumbo, Elisa, Rampazzo, Chiara, Bianchi, Vera

“…In cycling cells cytosolic de novo synthesis of deoxynucleotides is the main source of precursors for mitochondrial (mt) DNA synthesis. The transfer of…”
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Functional Characterization of drim2, the Drosophila melanogaster Homolog of the Yeast Mitochondrial Deoxynucleotide Transporter by Da-Rè, Caterina, Franzolin, Elisa, Biscontin, Alberto, Piazzesi, Antonia, Pacchioni, Beniamina, Gagliani, Maria Cristina, Mazzotta, Gabriella, Tacchetti, Carlo, Zordan, Mauro A., Zeviani, Massimo, Bernardi, Paolo, Bianchi, Vera, De Pittà, Cristiano, Costa, Rodolfo

“…The CG18317 gene (drim2) is the Drosophila melanogaster homolog of the Saccharomyces cerevisiae Rim2 gene, which encodes a pyrimidine (deoxy)nucleotide…”
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SAMHD1, a new actor in the regulation of DNA precursors in mammalian cells by Bianchi, Vera, Franzolin, Elisa, Rampazzo, Chiara, Ferraro, Paola, Miazzi, Cristina, Pontarin, Giovanna, Reichard, Peter

“…Abstract only SAMHD1 was discovered in the immune system where it restricts HIV‐1 infection. Mutations lead to mitochondrial DNA deletions in Aicardi‐Goutièrez…”
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Synthesis of Mitochondrial DNA Precursors during Myogenesis, an Analysis in Purified C2C12 Myotubes<inline-graphic xlink:href="sbox.jpg"/> by Frangini, Miriam, Franzolin, Elisa, Chemello, Francesco, Laveder, Paolo, Romualdi, Chiara, Bianchi, Vera, Rampazzo, Chiara

“…Background: In developing muscle, stimulation of mitochondrial biogenesis and mtDNA expansion occur with down-regulation of deoxynucleotide synthesis. Results:…”
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Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances: Nucleotide Pool Damage and Its Biological Consequences by RAMPAZZO, Chiara, MIAZZI, Cristina, FRANZOLIN, Elisa, PONTARIN, Giovanna, FERRARO, Paola, FRANGINI, Miriam, REICHARD, Peter, BIANCHI, Vera

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Unchanged thymidine triphosphate pools and thymidine metabolism in two lines of thymidine kinase 2-mutated fibroblasts by Frangini, Miriam, Rampazzo, Chiara, Franzolin, Elisa, Lara, Mari-Carmen, Vilà, Maya R, Martí, Ramon, Bianchi, Vera

“…Mitochondrial thymidine kinase (TK2) catalyzes the phosphorylation of thymidine in mitochondria. Its function becomes essential for dTTP synthesis in…”
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Bromovinyl-deoxyuridine: A selective substrate for mitochondrial thymidine kinase in cell extracts by Franzolin, Elisa, Rampazzo, Chiara, Pérez-Pérez, María-Jesús, Hernández, Ana-Isabel, Balzarini, Jan, Bianchi, Vera

“…Cellular models of mitochondrial thymidine kinase (TK2) deficiency require a reliable method to measure TK2 activity in whole cell extracts containing two…”
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