Cytogenetic study of spontaneous abortions by transabdominal villus sampling and direct analysis of villi

We report our experience in a cytogenetic study of 93 spontaneous abortions. Specimens were obtained by transabdominal chorionic villus sampling (TACVS) in women requesting prenatal diagnosis by chorionic villus sampling (CVS) but in whom an arrested pregnancy had been diagnosed during the ultrasoun...

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Bibliographic Details
Published in:	Prenatal diagnosis Vol. 19; no. 7; pp. 601 - 603
Main Authors:	Sánchez, José María, Franzi, Lilian, Collia, Federico, De Díaz, Silvia L., Panal, Marcelo, Dubner, Marcela
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01-07-1999 Wiley
Subjects:	Abortion, Spontaneous - genetics Adult Biological and medical sciences Chorionic Villi Sampling - methods chorionic villus sampling Chromosome Aberrations cytogenetic diagnosis Female Gestational Age Gynecology. Andrology. Obstetrics Humans Karyotyping Management. Prenatal diagnosis Medical sciences Pregnancy Pregnancy. Fetus. Placenta spontaneous abortion Chromosomal aberration Human Pregnancy disorders Pathogenesis Abortion In utero Percutaneous route Prenatal Cytogenetics Abdominal route Chorionic villi sampling Fetus Death Diagnosis Karyotype
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Summary:	We report our experience in a cytogenetic study of 93 spontaneous abortions. Specimens were obtained by transabdominal chorionic villus sampling (TACVS) in women requesting prenatal diagnosis by chorionic villus sampling (CVS) but in whom an arrested pregnancy had been diagnosed during the ultrasound examination. Our success rate, i.e. the percentage of cases where we obtained results, was 91.4 per cent, and the rate of abnormalities—mostly aneuploidies and polyploidies—was 62.3 per cent. In normal cases, masculine:feminine ratio was 1:1. These results confirm those obtained by other groups earlier this decade and allow us to conclude that, for the cytogenetic study of spontaneous abortions, CVS is a better approach than the culture of the products of conception after evacuation, because the success rate is higher and because it provides certainty that the specimens obtained are of fetal origin. Copyright © 1999 John Wiley & Sons, Ltd.
Bibliography:	istex:068C19B7E91EBBDA777A4E2C5455930FF362F091 ark:/67375/WNG-QNSZ1D39-J ArticleID:PD564 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0197-3851 1097-0223
DOI:	10.1002/(SICI)1097-0223(199907)19:7<601::AID-PD564>3.0.CO;2-0