Search Results - "Franz, Michael R."
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Repolarization Alternans Reveals Vulnerability to Human Atrial Fibrillation
Published in Circulation (New York, N.Y.) (28-06-2011)“…The substrates for human atrial fibrillation (AF) are poorly understood, but involve abnormal repolarization (action potential duration [APD]). We hypothesized…”
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QRS micro-fragmentation as a mortality predictor
Published in European heart journal (21-10-2022)“…Fragmented QRS complex with visible notching on standard 12-lead electrocardiogram (ECG) is understood to represent depolarization abnormalities and to signify…”
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T-Wave Alternans, Restitution of Human Action Potential Duration, and Outcome
Published in Journal of the American College of Cardiology (18-12-2007)“…T-Wave Alternans, Restitution of Human Action Potential Duration, and Outcome Sanjiv M. Narayan, Michael R. Franz, Gautam Lalani, Jason Kim, Ashwani Sastry We…”
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Rhythmic Aortic Contractions Induced by Electrical Stimulation In Vivo in the Rat
Published in PloS one (01-07-2015)“…For over a century, the behavior of the aorta and other large arteries has been described as passive elastic tubes in which no active contraction occurs in the…”
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Atrial fibrillation: Can electrograms be interpreted without repolarization information?
Published in Heart rhythm (01-04-2016)Get full text
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Autonomic modulation and antiarrhythmic therapy in a model of long QT syndrome type 3
Published in Cardiovascular research (01-07-2010)“…Aims Clinical observations in patients with long QT syndrome carrying sodium channel mutations (LQT3) suggest that bradycardia caused by parasympathetic…”
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To the Editor— Propranolol, a β-adrenoreceptor blocker, prevents arrhythmias also by its sodium channel blocking effect
Published in Heart rhythm (01-03-2014)Get full text
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Amiodarone prevents wave front-tail interactions in patients with heart failure: an in silico study
Published in American journal of physiology. Heart and circulatory physiology (01-11-2023)“…Amiodarone (AM) is an antiarrhythmic drug whose chronic use has proved effective in preventing ventricular arrhythmias in a variety of patient populations,…”
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Alternans of atrial action potentials during atrial flutter as a precursor to atrial fibrillation
Published in Circulation (New York, N.Y.) (08-10-2002)“…The mechanisms underlying the transition of typical atrial flutter (Afl) to fibrillation (AF) remain unclear. We set out to test the hypothesis that Afl…”
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Global Endocardial Electrical Restitution in Human Right and Left Ventricles Determined by Noncontact Mapping
Published in Journal of the American College of Cardiology (20-09-2005)“…This study was aimed at evaluating global characteristics of electrical restitution in the human ventricle using noncontact mapping. Steep action potential…”
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Monophasic Action Potential Recordings in Humans
Published in Journal of cardiovascular electrophysiology (01-07-2007)“…Bridging basic and clinical electrophysiology has been facilitated by monophasic action potential recordings. The electrocardiogram is a useful clinical…”
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Gadolinium decreases stretch-induced vulnerability to atrial fibrillation
Published in Circulation (New York, N.Y.) (09-05-2000)“…Atrial fibrillation (AF) is frequently associated with atrial dilatation caused by pressure or volume overload. Stretch-activated channels (SACs) have been…”
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Ventricular Fibrillation Induced by Stretch Pulse: Implications for Sudden Death Due to Commotio Cordis
Published in Journal of cardiovascular electrophysiology (01-09-2006)“…Introduction: Nonpenetrating chest wall impact (commotio cordis) may lead to sudden cardiac death due to the acute initiation of ventricular fibrillation (VF)…”
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Action potential characterization in intact mouse heart: steady-state cycle length dependence and electrical restitution
Published in American journal of physiology. Heart and circulatory physiology (01-01-2007)“…Transgenic mice have been increasingly utilized to investigate the molecular mechanisms of cardiac arrhythmias, yet the rate dependence of the murine action…”
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Comparative pharmacophysiology of vernakalant, ranolazine, and d -sotalol in canine pulmonary vein sleeve preparations: new flavors or same old taste?
Published in Heart rhythm (01-03-2012)Get full text
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A model for human action potential dynamics in vivo
Published in American journal of physiology. Heart and circulatory physiology (01-03-2020)“…Computational modeling based on experimental data remains an important component in cardiac electrophysiological research, especially because clinical data…”
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Intrathoracic Impedance Preceding Ventricular Tachyarrhythmia Episodes
Published in Pacing and clinical electrophysiology (01-08-2010)“…Background: Heart failure is associated with ventricular tachyarrhythmias (VT/VF). Fluid accumulation during worsened heart failure may trigger VT/VF…”
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Giant T―U Waves Precede Torsades de Pointes in Long QT Syndrome: A Systematic Electrocardiographic Analysis in Patients With Acquired and Congenital QT Prolongation
Published in Journal of the American College of Cardiology (07-07-2009)“…This study sought to identify electrocardiographic (ECG) criteria that are associated with initiation of torsades de pointes (TdP) in patients with acquired…”
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Amiodarone and dronedarone: The worker bee and the drone?
Published in Heart rhythm (01-09-2010)Get full text
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