Search Results - "Frantisek, Saudek"

Evidence-informed clinical practice recommendations for treatment of type 1 diabetes complicated by problematic hypoglycemia by Choudhary, Pratik, Rickels, Michael R, Senior, Peter A, Vantyghem, Marie-Christine, Maffi, Paola, Kay, Thomas W, Keymeulen, Bart, Inagaki, Nobuya, Saudek, Frantisek, Lehmann, Roger, Hering, Bernhard J

“…Problematic hypoglycemia, defined as two or more episodes per year of severe hypoglycemia or as one episode associated with impaired awareness of hypoglycemia,…”
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NEUROD1 Is Required for the Early α and β Endocrine Differentiation in the Pancreas by Bohuslavova, Romana, Smolik, Ondrej, Malfatti, Jessica, Berkova, Zuzana, Novakova, Zaneta, Saudek, Frantisek, Pavlinkova, Gabriela

“…Diabetes is a metabolic disease that involves the death or dysfunction of the insulin-secreting β cells in the pancreas. Consequently, most diabetes research…”
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NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development by Bohuslavova, Romana, Fabriciova, Valeria, Smolik, Ondrej, Lebrón-Mora, Laura, Abaffy, Pavel, Benesova, Sarka, Zucha, Daniel, Valihrach, Lukas, Berkova, Zuzana, Saudek, Frantisek, Pavlinkova, Gabriela

“…NEUROD1 is a transcription factor that helps maintain a mature phenotype of pancreatic β cells. Disruption of Neurod1 during pancreatic development causes…”
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Early worsening of diabetic retinopathy after simultaneous pancreas and kidney transplantation—Myth or reality? by Voglová, Barbora, Hladíková, Zuzana, Nemétová, Lenka, Zahradnická, Martina, Kesslerová, Kateřina, Sosna, Tomáš, Lipár, Květoslav, Kožnarová, Radomíra, Girman, Peter, Saudek, František

“…Early worsening of diabetic retinopathy due to sudden glucose normalization is a feared complication of pancreas transplantation; however, its rate or severity…”
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Bioluminescence Imaging In Vivo Confirms the Viability of Pancreatic Islets Transplanted into the Greater Omentum by Hladíková, Zuzana, Voglová, Barbora, Pátíková, Alžběta, Berková, Zuzana, Kříž, Jan, Vojtíšková, Alžběta, Leontovyč, Ivan, Jirák, Daniel, Saudek, František

“…Purpose The liver is the most widely used site for pancreatic islet transplantation. However, several site-specific limitations impair functional success, with…”
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Increase in lumbar spine but not distal radius bone mineral density in adults after pancreas kidney transplantation by Kratochvílová, Simona, Maratova, Klara, Sumnik, Zdenek, Brunová, Jana, Hlávka, Zdeněk, Girman, Peter, Saudek, František, Soucek, Ondrej

“…Osteoporosis occurs in every third individual after simultaneous pancreas kidney transplantation (SPKT). Currently used bone measures insufficiently predict…”
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Sirolimus vs mycophenolate mofetil (MMF) in primary combined pancreas and kidney transplantation. Results of a long‐term prospective randomized study by Girman, Peter, Lipár, Květoslav, Kočík, Matěj, Voska, Luděk, Kožnarová, Radomíra, Marada, Tomáš, Lánská, Věra, Saudek, František

“…The study was intended to compare pancreas graft survival rates in two groups of pancreas and kidney transplant recipients prospectively randomized to…”
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Automated Analysis of Microscopic Images of Isolated Pancreatic Islets by Habart, David, Švihlik, Jan, Schier, Jan, Cahová, Monika, Girman, Peter, Zacharovová, Klra, Berková, Zuzana, Kříž, Jan, Fábryová, Eva, Kosinová, Lucie, Papáčková, Zuzana, Kybic, Jan, Saudek, Frantiek

“…Clinical islet transplantation programs rely on the capacities of individual centers to quantify isolated islets. Current computer-assisted methods require…”
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Synthetic mRNA is a more reliable tool for the delivery of DNA-targeting proteins into the cell nucleus than fusion with a protein transduction domain by Leontovyc, Ivan, Habart, David, Loukotova, Sarka, Kosinova, Lucie, Kriz, Jan, Saudek, Frantisek, Koblas, Tomas

“…Cell reprogramming requires efficient delivery of reprogramming transcription factors into the cell nucleus. Here, we compared the robustness and workload of…”
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IsletSwipe, a mobile platform for expert opinion exchange on islet graft images by Habart, David, Koza, Adam, Leontovyc, Ivan, Kosinova, Lucie, Berkova, Zuzana, Kriz, Jan, Zacharovova, Klara, Brinkhof, Bas, Cornelissen, Dirk-Jan, Magrane, Nicholas, Bittenglova, Katerina, Capek, Martin, Valecka, Jan, Habartova, Alena, Saudek, František

“…We previously developed a deep learning-based web service (IsletNet) for an automated counting of isolated pancreatic islets. The neural network training is…”
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Magnetic Resonance Imaging of Pancreatic Islets Transplanted Into the Liver in Humans by SAUDEK, František, JIRAK, Daniel, GIRMAN, Peter, HERYNEK, Vit, DEZORTOVA, Monika, KRIZ, Jan, PEREGRIN, Jan, BERKOVA, Zuzana, ZACHAROVOVA, Klára, HAJEK, Milan

“…In vitro labeling of pancreatic islets by iron nanoparticles enables their detection as hypoitnense spots on serial magnetic resonance (MR) images. We report…”
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ISL1 controls pancreatic alpha cell fate and beta cell maturation by Bohuslavova, Romana, Fabriciova, Valeria, Lebrón-Mora, Laura, Malfatti, Jessica, Smolik, Ondrej, Valihrach, Lukas, Benesova, Sarka, Zucha, Daniel, Berkova, Zuzana, Saudek, Frantisek, Evans, Sylvia M, Pavlinkova, Gabriela

“…Glucose homeostasis is dependent on functional pancreatic α and ß cells. The mechanisms underlying the generation and maturation of these endocrine cells…”
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Retrospective Analysis of Bone Metabolism in Patients on Waiting List for Simultaneous Pancreas-Kidney Transplantation by Lánská, Věra, Wohl, Petr, Brunová, Jana, Kratochvílová, Simona, Saudek, František

“…Posttransplant osteoporosis, which evolves from preexisting bone pathologies, represents a serious complication with deteriorating consequences. The aim of our…”
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Nkx6.1 decline accompanies mitochondrial DNA reduction but subtle nucleoid size decrease in pancreatic islet β-cells of diabetic Goto Kakizaki rats by Špaček, Tomáš, Pavluch, Vojtěch, Alán, Lukáš, Capková, Nikola, Engstová, Hana, Dlasková, Andrea, Berková, Zuzana, Saudek, František, Ježek, Petr

“…Hypertrophic pancreatic islets (PI) of Goto Kakizaki (GK) diabetic rats contain a lower number of β-cells vs . non-diabetic Wistar rat PI. Remaining β-cells…”
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Unstable Expression of Commonly Used Reference Genes in Rat Pancreatic Islets Early after Isolation Affects Results of Gene Expression Studies by Kosinová, Lucie, Cahová, Monika, Fábryová, Eva, Týcová, Irena, Koblas, Tomáš, Leontovyč, Ivan, Saudek, František, Kříž, Jan

“…The use of RT-qPCR provides a powerful tool for gene expression studies; however, the proper interpretation of the obtained data is crucially dependent on…”
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MRI of transplanted pancreatic islets by Jirák, Daniel, Kríz, Jan, Herynek, Vít, Andersson, Benita, Girman, Peter, Burian, Martin, Saudek, František, Hájek, Milan

“…A promising treatment method for type 1 diabetes mellitus is transplantation of pancreatic islets containing β‐cells. The aim of this study was to develop an…”
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Reprogramming of Pancreatic Exocrine Cells AR42J Into Insulin-producing Cells Using mRNAs for Pdx1, Ngn3, and MafA Transcription Factors by Koblas, Tomas, Leontovyc, Ivan, Loukotova, Sarka, Kosinova, Lucie, Saudek, Frantisek

“…Direct reprogramming of pancreatic nonendocrine cells into insulin-producing β-cells represents a promising approach for the treatment of insulin-dependent…”
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4Pi microscopy reveals an impaired three-dimensional mitochondrial network of pancreatic islet β-cells, an experimental model of type-2 diabetes by Dlasková, Andrea, Špaček, Tomáš, Šantorová, Jitka, Plecitá-Hlavatá, Lydie, Berková, Zuzana, Saudek, František, Lessard, Mark, Bewersdorf, Joerg, Ježek, Petr

“…Insulin production in pancreatic β-cells is critically linked to mitochondrial oxidative phosphorylation. Increased ATP production triggered by blood glucose…”
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Hypoglycemia and Glucocorticoid-free Immunosuppression are Related With Low Dehydroepiandrosterone Sulfate Level by Zahradnicka, Martina, Saudek, Frantisek, Lipar, Kvetoslav, Skibova, Jelena

“…Low dehydroepiandrosterone sulfate (DHEAS) levels and a high cortisol/ DHEAS ratio are associated with higher mortality in elderly, dialyzed, and…”
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Decellularized Pancreatic Tail as Matrix for Pancreatic Islet Transplantation into the Greater Omentum in Rats by Berkova, Zuzana, Zacharovova, Klara, Patikova, Alzbeta, Leontovyc, Ivan, Hladikova, Zuzana, Cerveny, David, Tihlarikova, Eva, Nedela, Vilem, Girman, Peter, Jirak, Daniel, Saudek, Frantisek

“…Infusing pancreatic islets into the portal vein currently represents the preferred approach for islet transplantation, despite considerable loss of islet mass…”
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