Search Results - "Fransson, Lars"

Interplay between glypican-1, amyloid-β and tau phosphorylation in human neural stem cells by Cheng, Fang, Fransson, Lars-Åke, Mani, Katrin

“…[Display omitted] •In Alzheimer’s disease (AD) amyloid beta (Aβ) enhances hyperphosphorylation of tau.•p-tau 181, p-tau 217, and p-tau 231 distinguish AD from…”
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Interplay between APP and glypican-1 processing and α-synuclein aggregation in undifferentiated and differentiated human neural progenitor cells by Cheng, Fang, Fransson, Lars-Åke, Mani, Katrin

“…Abstract In Parkinson’s disease, there is an accumulation of α-synuclein (SYN) aggregates in neurons, which is promoted by neuroinflammation. In neural cells,…”
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Complex modulation of cytokine-induced α-synuclein aggregation by glypican-1-derived heparan sulfate in neural cells by Cheng, Fang, Fransson, Lars-Åke, Mani, Katrin

“…Abstract In Parkinson’s disease (PD), there is accumulation of α-synuclein (SYN) aggregates in neurons, which is promoted by neuroinflammation. The cytokines…”
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Proinflammatory cytokines induce accumulation of glypican-1-derived heparan sulfate and the C-terminal fragment of β-cleaved APP in autophagosomes of dividing neuronal cells by Cheng, Fang, Fransson, Lars-Åke, Mani, Katrin

“…Abstract Proinflammatory cytokines stimulate expression of β-secretase, which increases processing of amyloid precursor protein (APP), ultimately leading to…”
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Reversal of apolipoprotein E4-dependent or chemical-induced accumulation of APP degradation products by vitamin C-induced release of heparan sulfate from glypican-1 by Cheng, Fang, Fransson, Lars-Åke, Mani, Katrin

“…The Apolipoprotein E4 (ApoE4) genotype is the most influential risk factor for sporadic Alzheimer's disease. It appears to be associated with retarded…”
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The cyanobacterial neurotoxin β-N-methylamino-l-alanine prevents addition of heparan sulfate to glypican-1 and increases processing of amyloid precursor protein in dividing neuronal cells by Cheng, Fang, Fransson, Lars-Åke, Mani, Katrin

“…The neurotoxin β-N-methylamino-l-alanine replaces l-serine in proteins and produces Alzheimer-like pathology. In proteoglycans, e.g. glypican-1, this should…”
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Nucleolin is a nuclear target of heparan sulfate derived from glypican-1 by Cheng, Fang, Belting, Mattias, Fransson, Lars-Åke, Mani, Katrin

“…The recycling, S-nitrosylated heparan sulfate (HS) proteoglycan glypican-1 releases anhydromannose (anMan)-containing HS chains by a nitrosothiol-catalyzed…”
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Cytochrome b561, copper, β-cleaved amyloid precursor protein and niemann-pick C1 protein are involved in ascorbate-induced release and membrane penetration of heparan sulfate from endosomal S-nitrosylated glypican-1 by Cheng, Fang, Fransson, Lars-Åke, Mani, Katrin

“…Ascorbate-induced release of heparan sulfate from S-nitrosylated heparan sulfate proteoglycan glypican-1 takes place in endosomes. Heparan sulfate penetrates…”
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Common traffic routes for imported spermine and endosomal glypican-1-derived heparan sulfate in fibroblasts by Cheng, Fang, Fransson, Lars-Åke, Mani, Katrin

“…Import of the polyamine spermine from the extracellular environment depends on the presence of cell surface heparan sulfate proteoglycans, such as glypican-1…”
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Amyloid Precursor Protein (APP)/APP-like Protein 2 (APLP2) Expression Is Required to Initiate Endosome-Nucleus-Autophagosome Trafficking of Glypican-1-derived Heparan Sulfate by Cheng, Fang, Cappai, Roberto, Lidfeldt, Jon, Belting, Mattias, Fransson, Lars-Åke, Mani, Katrin

“…Anhydromannose (anMan)-containing heparan sulfate (HS) derived from the proteoglycan glypican-1 is generated in endosomes by an endogenously or…”
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Suppression of glypican-1 autodegradation by NO-deprivation correlates with nuclear accumulation of amyloid beta in normal fibroblasts by Cheng, Fang, Fransson, Lars-Åke, Mani, Katrin

“…Heparan sulfate (HS)-containing, S-nitrosylated (SNO) glypican-1 (Gpc-1) releases anhydromannose-containing HS (anMan-HS) by SNO-catalyzed autodegradation in…”
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Non-toxic amyloid beta formed in the presence of glypican-1 or its deaminatively generated heparan sulfate degradation products by Cheng, Fang, Ruscher, Karsten, Fransson, Lars-Åke, Mani, Katrin

“…The amyloid beta (Aβ) peptides (mainly Aβ40 and Aβ42), which are derived from the amyloid precursor protein (APP), can oligomerize into antibody A11-positive,…”
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Rapid nuclear transit and impaired degradation of amyloid β and glypican-1-derived heparan sulfate in Tg2576 mouse fibroblasts by Cheng, Fang, Fransson, Lars-Åke, Mani, Katrin

“…Anhydromannose (anMan)-containing heparan sulfate (HS) derived from S-nitrosylated glypican-1 is generated in endosomes by an endogenously or ascorbate induced…”
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Hypoxia induces NO-dependent release of heparan sulfate in fibroblasts from the Alzheimer mouse Tg2576 by activation of nitrite reduction by Cheng, Fang, Bourseau-Guilmain, Erika, Belting, Mattias, Fransson, Lars-Åke, Mani, Katrin

“…There is a functional relationship between the heparan sulfate proteoglycan glypican-1 and the amyloid precursor protein (APP) of Alzheimer disease. In…”
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Attenuation of Tumor Growth by Formation of Antiproliferative Glycosaminoglycans Correlates with Low Acetylation of Histone H3 by NILSSON, Ulrika, JOHNSSON, Richard, FRANSSON, Lars-Ake, ELLERVIK, Ulf, MANI, Katrin

“…Glycosaminoglycan (GAG) chains anchored to core proteins form proteoglycans, widely distributed cell-surface macromolecules with multiple functions, such as…”
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Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation by Cheng, Fang, Cappai, Roberto, Ciccotosto, Giuseppe D, Svensson, Gabriel, Multhaup, Gerd, Fransson, Lars-Åke, Mani, Katrin

“…Amyloid β (Aβ) is generated from the copper- and heparan sulfate (HS)-binding amyloid precursor protein (APP) by proteolytic processing. APP supports…”
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Non-conserved, S-nitrosylated cysteines in glypican-1 react with N-unsubstituted glucosamines in heparan sulfate and catalyze deaminative cleavage by Cheng, Fang, Svensson, Gabriel, Fransson, Lars-Åke, Mani, Katrin

“…The membrane lipid-anchored glypicans (Gpcs) [heparan sulfate (HS) proteoglycans (PGs)] are present in both vertebrates and invertebrates and serve as…”
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Novel aspects of vitamin C: how important is glypican-1 recycling? by Fransson, Lars-Åke, Mani, Katrin

“…The reduced form of vitamin C, ascorbic acid, is well known for its function as an antioxidant and as a protective agent against scurvy. However, many recent…”
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Involvement of glypican-1 autoprocessing in scrapie infection by Löfgren, Kajsa, Cheng, Fang, Fransson, Lars-Åke, Bedecs, Katarina, Mani, Katrin

“…The copper‐binding cellular prion protein (PrPC) and the heparan sulphate (HS)‐containing proteoglycan glypican‐1 (Gpc‐1) can both be attached to lipid rafts…”
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Glypicans by Fransson, Lars-Åke

“…A family of lipid-linked heparan sulfate (HS) proteoglycans, later named glypicans, were identified some 15 years ago. The discoveries that mutations in genes…”
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