Accelerated Epigenetic Aging in Peripheral Blood does not Predict Dementia Risk

Accelerated Epigenetic Aging in Peripheral Blood does not Predict Dementia Risk

There is strong evidence that epigenetic age acceleration is associated with increased risk of later-life diseases and all-cause mortality. However, there is currently limited evidence that suggests accelerated epigenetic age is associated with dementia risk. This study aims to clarify whether epige...

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Bibliographic Details
Published in:Current Alzheimer research Vol. 18; no. 5; p. 443
Main Authors: Fransquet, P D, Lacaze, P, Saffery, R, Shah, R C, Vryer, R, Murray, A, Woods, R L, Ryan, J
Format: Journal Article
Language:English
Published: United Arab Emirates 2021
Subjects:
Aged
Aging - genetics
Biomarkers - blood
Dementia - blood
Dementia - epidemiology
Dementia - genetics
DNA Methylation
Epigenesis, Genetic
Female
Humans
Male
hannum
grimAge
horvath
Accelerated Aging
phenoAge
DNA methylation
dementia
epigenetic clock
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Summary:There is strong evidence that epigenetic age acceleration is associated with increased risk of later-life diseases and all-cause mortality. However, there is currently limited evidence that suggests accelerated epigenetic age is associated with dementia risk. This study aims to clarify whether epigenetic biomarkers of accelerated aging can predict dementia risk, which is an important consideration as aging is the greatest risk factor for the disease. DNA methylation was measured in peripheral blood samples provided by 160 participants from the ASPirin in Reducing Events in the Elderly study, including 73 pre-symptomatic dementia cases and 87 controls matched for age, sex, and smoking and education status. Epigenetic age was calculated using Horvath, Hannum, GrimAge and PhenoAge DNA methylation clocks, and age acceleration (the disparity between chronological age and epigenetic age) was determined. There was no difference in age acceleration between dementia cases and controls. In males, only Hannum's intrinsic epigenetic age acceleration was increased in pre-symptomatic dementia cases compared to controls (Δ +1.8 years, p = 0.03). These findings provide no strong evidence that accelerated epigenetic aging measured in peripheral blood can predict dementia risk.
ISSN:1875-5828
DOI:10.2174/1567205018666210823100721