Search Results - "Franson, R C"

High levels of inflammatory phospholipase A2 activity in lumbar disc herniations by Saal, J S, Franson, R C, Dobrow, R, Saal, J A, White, A H, Goldthwaite, N

“…Inflammation of neural elements is frequently mentioned clinically in association with lumbar radiculopathy. Mechanical embarrassment of neural elements by…”
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Human disc phospholipase A2 is inflammatory by Franson, R C, Saal, J S, Saal, J A

“…Human discs have been demonstrated to contain high levels of phospholipase A2. As the enzyme responsible for the liberation of arachidonic acid from membranes,…”
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Role of human sperm phospholipase A2 in fertilization: effects of a novel inhibitor of phospholipase A2 activity on membrane perturbations and oocyte penetration by FRY, M. R, GHOSH, S. S, EAST, J. M, FRANSON, R. C

“…Phospholipase A2 was isolated from human sperm and its potential role in the membrane fusion events of fertilization was examined. Highly purified enzyme…”
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Edema-inducing activity of phospholipase A2 purified from human synovial fluid and inhibition by aristolochic acid by VISHWANATH, B. S, FAWZY, A. A, FRANSON, R. C

“…A neutral-active, Ca2+-dependent phospholipase A2 (PLA2) purified 11,000-fold from human synovial fluid (HSF) induced edema when injected into the mouse foot…”
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Inhibitor of phospholipase A2 blocks eicosanoid and platelet activating factor biosynthesis and has topical anti-inflammatory activity by Tramposch, K M, Chilton, F H, Stanley, P L, Franson, R C, Havens, M B, Nettleton, D O, Davern, L B, Darling, I M, Bonney, R J

“…The effect of a phospholipase A2 (PLA2) inhibitor on leukotriene, prostaglandin and platelet activating factor (PAF) biosynthesis in isolated cells and in vivo…”
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Early secretory events during intestinal graft preservation by Sonnino, R.E., Wang, L., Franson, R.C.

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Cellular regulation of arachidonate mobilization and metabolism by Rosenthal, M.D., Rzigalinski, B.A., Blackmore, P.F., Franson, R.C.

“…Synthesis of eicosanoids is initiated by signal transduction cascades which result in the hydrolysis of free arachidonic acid from membrane phospholipids. Both…”
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Novel inhibitor of phospholipase A2 with topical anti-inflammatory activity by Tramposch, K M, Steiner, S A, Stanley, P L, Nettleton, D O, Franson, R C, Lewin, A H, Carroll, F I

“…Activation of a phospholipase A2 (PLA2) is a key step in the production of precursors for the biosynthesis of lipid mediators of inflammation. Inhibition of…”
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Haemodialysis activates phospholipase A2 enzyme by VISHWANATH, B. S, FUX, C. A, UEHLINGER, D. E, FREY, B. M, FRANSON, R. C, FREY, F. J

“…Clinical and experimental evidence suggest that haemodialysis (HD) procedure is an inflammatory process. For the production of proinflammatory lipid mediators…”
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Modulation of phospholipase A2 activity associated with human sperm membranes by divalent cations and calcium antagonists by THAKKAR, J. K, EAST, J, FRANSON, R. C

“…Phospholipase A2 activity in sonicates and acid extracts of ejaculated, washed human sperm was measured using [1-14C] oleate-labeled autoclaved E. coli and…”
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Characterization and localization of neutral sphingomyelinase in bovine adrenal medulla by Bartolf, M, Franson, R C

“…Homogenates of bovine adrenal medullae hydrolyzed exogenous sphingomyelin at 4.3 +/- 1.6 nmol X mg-1 X min-1 and 97% of this sphingomyelinase activity was…”
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Swine as a model of skin inflammation : phospholipase A2-induced inflammation by NAIR, X, NETTLETON, D, CLEVER, D, TRAMPOSCH, K. M, GHOSH, S, FRANSON, R. C

“…A predictive animal model of skin inflammation is needed for the development of potential therapeutic agents. The existing models of inflammation rely on…”
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Phosphatidylinositol-specific phospholipase C activity of chromaffin granule-binding proteins by Creutz, C E, Dowling, L G, Kyger, E M, Franson, R C

“…Using [U-14C]phosphatidylinositol as substrate, Ca2+-dependent phospholipase C activity was detected in a group of bovine adrenal medullary proteins that bind…”
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Mechanism(s) of cytoprotective and anti-inflammatory activity of PGB1 oligomers: PGBx has potent anti-phospholipase A2 and anti-oxidant activity by Franson, R C, Rosenthal, M D, Regelson, W

“…We postulate that the anti-PLA2 and anti-oxidant activities may account for the broad spectrum protective effects of PGBx that were previously described. These…”
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Human Neutrophils Store Type II 14-kDa Phospholipase A2 in Granules and Secrete Active Enzyme in Response to Soluble Stimuli by Rosenthal, M.D., Gordon, M.N., Buescher, E.S., Slusser, J.H., Harris, L.K., Franson, R.C.

“…Although "secretory" type II 14-kDa phospholipase A2 (sPLA2) activity has been described in neutrophils, direct evidence of enzyme secretion has been elusive…”
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Separation and purification of a potent bactericidal/permeability-increasing protein and a closely associated phospholipase A2 from rabbit polymorphonuclear leukocytes. Observations on their relationship by Elsbach, P., Weiss, J., Franson, R.C., Beckerdite-Quagliata, S., Schneider, A., Harris, L.

“…Two antibacterial proteins from rabbit polymorphonuclear leukocytes, a potent bactericidal cationic protein that increases the envelope permeability of…”
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Inhibition of highly purified mammalian phospholipases A2 by non-steroidal anti-inflammatory agents. Modulation by calcium ions by Franson, R C, Eisen, D, Jesse, R, Lanni, C

“…Highly purified Ca2+-dependent phospholipases A2 that were isolated from human platelets, rabbit alveolar macrophages and peritoneal polymorphonuclear…”
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Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet by Bronner, C, Wiggins, C, Monté, D, Märki, F, Capron, A, Landry, Y, Franson, R C

“…Compound 48/80 inhibited phosphatidylinositol-specific phospholipase C activity from human platelets. Whereas 1 microgram/ml of compound 48/80 slightly…”
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Biomembrane-modulated, lysosomal phospholipase A2 contamination of chromaffin granule ghosts by Bartolf, M, Franson, R C

“…It was reported that subcellular fractionation of bovine adrenal medulla results in the separation of distinct, non-calcium-dependent phospholipases A2--one…”
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Activity of phospholipase A2 in plasma increases in uremia by Costello, J, Franson, R C, Landwehr, K, Landwehr, D M

“…We measured phospholipase A2 (PLA2; EC 3.1.1.4) activity in normal and uremic plasma, using [1-14C]oleate-labeled autoclaved Escherichia coli as substrate…”
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