Search Results - "Fransen, Marc"

The Peroxisome-Mitochondria Connection: How and Why? by Fransen, Marc, Lismont, Celien, Walton, Paul

“…Over the past decades, peroxisomes have emerged as key regulators in overall cellular lipid and reactive oxygen species metabolism. In mammals, these…”
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Peroxisomal Hydrogen Peroxide Metabolism and Signaling in Health and Disease by Lismont, Celien, Revenco, Iulia, Fransen, Marc

“…Hydrogen peroxide (H O ), a non-radical reactive oxygen species generated during many (patho)physiological conditions, is currently universally recognized as…”
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Peroxisomal metabolism and oxidative stress by Nordgren, Marcus, Fransen, Marc

“…Peroxisomes are ubiquitous and multifunctional organelles that are primarily known for their role in cellular lipid metabolism. As many peroxisomal enzymes…”
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Role of peroxisomes in ROS/RNS-metabolism: Implications for human disease by Fransen, Marc, Nordgren, Marcus, Wang, Bo, Apanasets, Oksana

“…Peroxisomes are cell organelles that play a central role in lipid metabolism. At the same time, these organelles generate reactive oxygen and nitrogen species…”
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Application of DEM-based metamodels in bulk handling equipment design: Methodology and DEM case study by Fransen, Marc P., Langelaar, Matthijs, Schott, Dingena L.

“…Developments in discrete element modelling (DEM) enable detailed modelling of granular flows in bulk handling equipment (BHE) but due to the computational…”
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The peroxisomal import receptor PEX5 functions as a stress sensor, retaining catalase in the cytosol in times of oxidative stress by Walton, Paul A., Brees, Chantal, Lismont, Celien, Apanasets, Oksana, Fransen, Marc

“…Accumulating evidence indicates that peroxisome functioning, catalase localization, and cellular oxidative balance are intimately interconnected. Nevertheless,…”
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Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk by Ivashchenko, Oksana, Van Veldhoven, Paul P, Brees, Chantal, Ho, Ye-Shih, Terlecky, Stanley R, Fransen, Marc

“…Reactive oxygen species (ROS) are at once unsought by-products of metabolism and critical regulators of multiple intracellular signaling cascades. In…”
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Mitochondrial fission factor (MFF) is a critical regulator of peroxisome maturation by Passmore, Josiah B., Carmichael, Ruth E., Schrader, Tina A., Godinho, Luis F., Ferdinandusse, Sacha, Lismont, Celien, Wang, Yunhong, Hacker, Christian, Islinger, Markus, Fransen, Marc, Richards, David M., Freisinger, Peter, Schrader, Michael

“…Peroxisomes are highly dynamic subcellular compartments with important functions in lipid and ROS metabolism. Impaired peroxisomal function can lead to severe…”
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Noncanonical and reversible cysteine ubiquitination prevents the overubiquitination of PEX5 at the peroxisomal membrane by Francisco, Tânia, Pedrosa, Ana G, Rodrigues, Tony A, Abalkhail, Tarad, Li, Hongli, Ferreira, Maria J, van der Heden van Noort, Gerbrand J, Fransen, Marc, Hettema, Ewald H, Azevedo, Jorge E

“…PEX5, the peroxisomal protein shuttling receptor, binds newly synthesized proteins in the cytosol and transports them to the organelle. During its stay at the…”
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Therapeutic concentrations of calcineurin inhibitors do not deregulate glutathione redox balance in human renal proximal tubule cells by Ramazani, Yasaman, Knops, Noël, Berlingerio, Sante Princiero, Adebayo, Oyindamola Christiana, Lismont, Celien, Kuypers, Dirk J, Levtchenko, Elena, van den Heuvel, Lambert P, Fransen, Marc

“…The calcineurin inhibitors (CNI) cyclosporine A and tacrolimus comprise the basis of immunosuppressive regimes in all solid organ transplantation. However,…”
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Import of peroxisomal membrane proteins: The interplay of Pex3p- and Pex19p-mediated interactions by Fujiki, Yukio, Matsuzono, Yuji, Matsuzaki, Takashi, Fransen, Marc

“…In contrast to the molecular mechanisms underlying import of peroxisomal matrix proteins, those involving the transport of membrane proteins remain rather…”
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PEX5, the Shuttling Import Receptor for Peroxisomal Matrix Proteins, Is a Redox‐Sensitive Protein by Apanasets, Oksana, Grou, Cláudia P., Van Veldhoven, Paul P., Brees, Chantal, Wang, Bo, Nordgren, Marcus, Dodt, Gabriele, Azevedo, Jorge E., Fransen, Marc

“…Mounting evidence suggests that oxidative stress impairs peroxisomal matrix protein import. This study provides direct evidence that the import of PTS1 matrix…”
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Peroxisome Dynamics in Cultured Mammalian Cells by Huybrechts, Sofie J, Van Veldhoven, Paul P, Brees, Chantal, Mannaerts, Guy P, Los, Georgyi V, Fransen, Marc

“…Despite the identification and characterization of various proteins that are essential for peroxisome biogenesis, the origin and the turnover of peroxisomes…”
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Identification of Ubiquitin-specific Protease 9X (USP9X) as a Deubiquitinase Acting on Ubiquitin-Peroxin 5 (PEX5) Thioester Conjugate by Grou, Cláudia P., Francisco, Tânia, Rodrigues, Tony A., Freitas, Marta O., Pinto, Manuel P., Carvalho, Andreia F., Domingues, Pedro, Wood, Stephen A., Rodríguez-Borges, José E., Sá-Miranda, Clara, Fransen, Marc, Azevedo, Jorge E.

“…Peroxin 5 (PEX5), the peroxisomal protein shuttling receptor, binds newly synthesized peroxisomal matrix proteins in the cytosol and promotes their…”
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A PEX7-Centered Perspective on the Peroxisomal Targeting Signal Type 2-Mediated Protein Import Pathway by Rodrigues, Tony A., Alencastre, Inês S., Francisco, Tânia, Brites, Pedro, Fransen, Marc, Grou, Cláudia P., Azevedo, Jorge E.

“…Peroxisomal matrix proteins are synthesized on cytosolic ribosomes and transported to the organelle by shuttling receptors. Matrix proteins containing a type 1…”
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Functional peroxisomes are required for β-cell integrity in mice by Baboota, Ritesh Kumar, Shinde, Abhijit Babaji, Lemaire, Katleen, Fransen, Marc, Vinckier, Stefan, Van Veldhoven, Paul P., Schuit, Frans, Baes, Myriam

“…Peroxisomes play a crucial role in lipid and reactive oxygen species metabolism, but their importance for pancreatic β-cell functioning is presently unknown…”
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Peroxisome degradation in mammals: mechanisms of action, recent advances, and perspectives by Nordgren, Marcus, Wang, Bo, Apanasets, Oksana, Fransen, Marc

“…Peroxisomes are remarkably dynamic organelles that participate in a diverse array of cellular processes, including the metabolism of lipids and reactive oxygen…”
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Ubiquitination of Mammalian Pex5p, the Peroxisomal Import Receptor by Carvalho, Andreia F., Pinto, Manuel P., Grou, Cláudia P., Alencastre, Inês S., Fransen, Marc, Sá-Miranda, Clara, Azevedo, Jorge E.

“…Protein translocation across the peroxisomal membrane requires the concerted action of numerous peroxins. One central component of this machinery is Pex5p, the…”
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Functional Analysis of GSTK1 in Peroxisomal Redox Homeostasis in HEK-293 Cells by Costa, Cláudio F, Lismont, Celien, Chornyi, Serhii, Li, Hongli, Hussein, Mohamed A F, Waterham, Hans R, Fransen, Marc

“…Peroxisomes serve as important centers for cellular redox metabolism and communication. However, fundamental gaps remain in our understanding of how the…”
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Enhanced Levels of Peroxisome-Derived H2O2 Do Not Induce Pexophagy but Impair Autophagic Flux in HEK-293 and HeLa Cells by Li, Hongli, Lismont, Celien, Costa, Cláudio F., Hussein, Mohamed A. F., Baes, Myriam, Fransen, Marc

“…Peroxisomes are functionally specialized organelles that harbor multiple hydrogen peroxide (H2O2)-producing and -degrading enzymes. Given that this oxidant…”
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