Azithromycin-loaded liposomal hydrogel: a step forward for enhanced treatment of MRSA-related skin infections

Azithromycin-loaded liposomal hydrogel: a step forward for enhanced treatment of MRSA-related skin infections

Azithromycin (AZT) encapsulated into various types of liposomes (AZT-liposomes) displayed pronounced activity against methicillin-resistant (MRSA) (1). The present study represents a follow-up to this previous work, attempting to further explore the anti-MRSA potential of AZT-liposomes when incorpor...

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Bibliographic Details
Published in:Acta Pharmaceutica Vol. 73; no. 4; pp. 559 - 579
Main Authors: Rukavina, Zora, Jøraholmen, May Wenche, Božić, Dunja, Frankol, Ivana, Gašparović, Petra Golja, Škalko-Basnet, Nataša, Klarić, Maja Šegvić, Vanić, Željka
Format: Journal Article Paper
Language:English
Published: Poland Sciendo 01-12-2023
De Gruyter Poland
Hrvatsko farmaceutsko društvo
Subjects:
Anti-Bacterial Agents - pharmacology
Antibacterial activity
Azithromycin
Azithromycin - pharmacology
Biocompatibility
Chitosan
Cytotoxicity
Drug resistance
Hydrogels
Hydrogels - pharmacology
liposomal hydrogel
Liposomes
Liposomes - pharmacology
Methicillin
Methicillin-Resistant Staphylococcus aureus
MRSA
Rheological properties
Skin
skin infections
Staphylococcus infections
Texture
topical antimicrobial therapy
Viscoelasticity
Zidovudine
chitosan
azithromycin
topical antimicrobial therapy
liposomal hydrogel
skin infections
MRSA
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Summary:Azithromycin (AZT) encapsulated into various types of liposomes (AZT-liposomes) displayed pronounced activity against methicillin-resistant (MRSA) (1). The present study represents a follow-up to this previous work, attempting to further explore the anti-MRSA potential of AZT-liposomes when incorporated into chitosan hydrogel (CHG). Incorporation of AZT-liposomes into CHG (liposomal CHGs) was intended to ensure proper viscosity and texture properties of the formulation, modification of antibiotic release, and enhanced antibacterial activity, aiming to upgrade the therapeutical potential of AZT-liposomes in localized treatment of MRSA-related skin infections. Four different liposomal CHGs were evaluated and compared on the grounds of antibacterial activity against MRSA, AZT release profiles, cytotoxicity, as well as texture, and rheological properties. To our knowledge, this study is the first to investigate the potential of liposomal CHGs for the topical localized treatment of MRSA-related skin infections. CHG ensured proper viscoelastic and texture properties to achieve prolonged retention and prolonged release of AZT at the application site, which resulted in a boosted anti-MRSA effect of the entrapped AZT-liposomes. With respect to anti-MRSA activity and biocompatibility, formulation CATL-CHG (cationic liposomes in CHG) is considered to be the most promising formulation for the treatment of MRSA-related skin infections.
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content type line 23
309817
ISSN:1846-9558
1330-0075
1846-9558
DOI:10.2478/acph-2023-0042