Search Results - "Franko, Nina"

Evaluation of THP-1 and Jurkat Cell Lines Coculture for the In Vitro Assessment of the Effects of Immunosuppressive Substances by Franko, Nina, Sollner Dolenc, Marija

“…The strong appeal to reduce animal testing calls for the development and validation of in vitro, in chemico and in silico models that would replace the need…”
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TBP , PPIA , YWHAZ and EF1A1 Are the Most Stably Expressed Genes during Osteogenic Differentiation by Franko, Nina, Vrščaj, Lucija Ana, Zore, Taja, Ostanek, Barbara, Marc, Janja, Lojk, Jasna

“…RT-qPCR is the gold standard and the most commonly used method for measuring gene expression. Selection of appropriate reference gene(s) for normalization is a…”
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Inhibition of O-acetylserine sulfhydrylase by fluoroalanine derivatives by Franko, Nina, Grammatoglou, Konstantinos, Campanini, Barbara, Costantino, Gabriele, Jirgensons, Aigars, Mozzarelli, Andrea

“…O-acetylserine sulfhydrylase (OASS) is the pyridoxal 5′-phosphate dependent enzyme that catalyses the formation of L-cysteine in bacteria and plants. Its…”
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Combination of SAXS and Protein Painting Discloses the Three-Dimensional Organization of the Bacterial Cysteine Synthase Complex, a Potential Target for Enhancers of Antibiotic Action by Rosa, Brenda, Marchetti, Marialaura, Paredi, Gianluca, Amenitsch, Heinz, Franko, Nina, Benoni, Roberto, Giabbai, Barbara, De Marino, Maria Giovanna, Mozzarelli, Andrea, Ronda, Luca, Storici, Paola, Campanini, Barbara, Bettati, Stefano

“…The formation of multienzymatic complexes allows for the fine tuning of many aspects of enzymatic functions, such as efficiency, localization, stability, and…”
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Inhibitors of O-Acetylserine Sulfhydrylase with a Cyclopropane-Carboxylic Acid Scaffold Are Effective Colistin Adjuvants in Gram Negative Bacteria by Annunziato, Giannamaria, Spadini, Costanza, Marchetti, Marialaura, Franko, Nina, Pavone, Marialaura, Iannarelli, Mattia, Bruno, Agostino, Pieroni, Marco, Bettati, Stefano, Cabassi, Clotilde Silvia, Campanini, Barbara, Costantino, Gabriele

“…Antibacterial adjuvants are of great significance, since they allow one to downscale the therapeutic dose of conventional antibiotics and reduce the insurgence…”
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Refining the structure−activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms by Magalhães, Joana, Franko, Nina, Annunziato, Giannamaria, Pieroni, Marco, Benoni, Roberto, Nikitjuka, Anna, Mozzarelli, Andrea, Bettati, Stefano, Karawajczyk, Anna, Jirgensons, Aigars, Campanini, Barbara, Costantino, Gabriele

“…The lack of efficacy of current antibacterials to treat multidrug resistant bacteria poses a life-threatening alarm. In order to develop enhancers of the…”
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Discovery of Substituted (2-Aminooxazol-4-yl)Isoxazole-3-carboxylic Acids as Inhibitors of Bacterial Serine Acetyltransferase in the Quest for Novel Potential Antibacterial Adjuvants by Magalhães, Joana, Franko, Nina, Raboni, Samanta, Annunziato, Giannamaria, Tammela, Päivi, Bruno, Agostino, Bettati, Stefano, Armao, Stefano, Spadini, Costanza, Cabassi, Clotilde Silvia, Mozzarelli, Andrea, Pieroni, Marco, Campanini, Barbara, Costantino, Gabriele

“…Many bacteria and actinomycetales use L-cysteine biosynthesis to increase their tolerance to antibacterial treatment and establish a long-lasting infection. In…”
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Discovery of novel fragments inhibiting O-acetylserine sulphhydrylase by combining scaffold hopping and ligand-based drug design by Magalhães, Joana, Franko, Nina, Annunziato, Giannamaria, Welch, Martin, Dolan, Stephen K., Bruno, Agostino, Mozzarelli, Andrea, Armao, Stefano, Jirgensons, Aigars, Pieroni, Marco, Costantino, Gabriele, Campanini, Barbara

“…Several bacteria rely on the reductive sulphur assimilation pathway, absent in mammals, to synthesise cysteine. Reduction of virulence and decrease in…”
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A review on immunomodulatory effects of BPA analogues by Kodila, Anja, Franko, Nina, Sollner Dolenc, Marija

“…Bisphenol A (BPA) is a known endocrine disruptor found in many consumer products that humans come into contact with on a daily basis. Due to increasing…”
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Adverse outcomes of the newly emerging bisphenol A substitutes by Franko, Nina, Kodila, Anja, Sollner Dolenc, Marija

“…BPA and its analogues are facing increasingly stringent regulations restricting their use due to the increasing knowledge of their harmful effects. It is…”
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Integration of Enhanced Sampling Methods with Saturation Transfer Difference Experiments to Identify Protein Druggable Pockets by Magalhães, Joana, Annunziato, Giannamaria, Franko, Nina, Pieroni, Marco, Campanini, Barbara, Bruno, Agostino, Costantino, Gabriele

“…Saturation transfer difference (STD) is an NMR technique conventionally applied in drug discovery to identify ligand moieties relevant for binding to protein…”
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Modulation of Escherichia coli serine acetyltransferase catalytic activity in the cysteine synthase complex by Benoni, Roberto, De Bei, Omar, Paredi, Gianluca, Hayes, Christopher S., Franko, Nina, Mozzarelli, Andrea, Bettati, Stefano, Campanini, Barbara

“…In bacteria and plants, serine acetyltransferase (CysE) and O‐acetylserine sulfhydrylase‐A sulfhydrylase (CysK) collaborate to synthesize l‐Cys from l‐Ser…”
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Inhibition of Nonessential Bacterial Targets: Discovery of a Novel Serine O‑Acetyltransferase Inhibitor by Magalhães, Joana, Franko, Nina, Raboni, Samanta, Annunziato, Giannamaria, Tammela, Päivi, Bruno, Agostino, Bettati, Stefano, Mozzarelli, Andrea, Pieroni, Marco, Campanini, Barbara, Costantino, Gabriele

“…In ϒ-proteobacteria and Actinomycetales, cysteine biosynthetic enzymes are indispensable during persistence and become dispensable during growth or acute…”
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Investigational Studies on a Hit Compound Cyclopropane–Carboxylic Acid Derivative Targeting O‑Acetylserine Sulfhydrylase as a Colistin Adjuvant by Annunziato, Giannamaria, Spadini, Costanza, Franko, Nina, Storici, Paola, Demitri, Nicola, Pieroni, Marco, Flisi, Sara, Rosati, Lucrezia, Iannarelli, Mattia, Marchetti, Marialaura, Magalhaes, Joana, Bettati, Stefano, Mozzarelli, Andrea, Cabassi, Clotilde Silvia, Campanini, Barbara, Costantino, Gabriele

“…Antibacterial adjuvants are of great significance, since they allow the therapeutic dose of conventional antibiotics to be lowered and reduce the insurgence of…”
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Cyclopropane-1,2-dicarboxylic acids as new tools for the biophysical investigation of O-acetylserine sulfhydrylases by fluorimetric methods and saturation transfer difference (STD) NMR by Annunziato, Giannamaria, Pieroni, Marco, Benoni, Roberto, Campanini, Barbara, Pertinhez, Thelma A, Pecchini, Chiara, Bruno, Agostino, Magalhães, Joana, Bettati, Stefano, Franko, Nina, Mozzarelli, Andrea, Costantino, Gabriele

“…Cysteine is a building block for many biomolecules that are crucial for living organisms. O-Acetylserine sulfhydrylase (OASS), present in bacteria and plants…”
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New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals - a PARC (Partnership for the Assessment of Risk from Chemicals) project by Snapkow, Igor, Smith, Nicola M, Arnesdotter, Emma, Beekmann, Karsten, Blanc, Etienne B, Braeuning, Albert, Corsini, Emanuela, Sollner Dolenc, Marija, Duivenvoorde, Loes P M, Sundstøl Eriksen, Gunnar, Franko, Nina, Galbiati, Valentina, Gostner, Johanna M, Grova, Nathalie, Gutleb, Arno C, Hargitai, Rita, Janssen, Aafke W F, Krapf, Solveig A, Lindeman, Birgitte, Lumniczky, Katalin, Maddalon, Ambra, Mollerup, Steen, Parráková, Lucia, Pierzchalski, Arkadiusz, Pieters, Raymond H H, Silva, Maria J, Solhaug, Anita, Staal, Yvonne C M, Straumfors, Anne, Szatmári, Tünde, Turner, Jonathan D, Vandebriel, Rob J, Zenclussen, Ana Claudia, Barouki, Robert

“…As a complex system governing and interconnecting numerous functions within the human body, the immune system is unsurprisingly susceptible to the impact of…”
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