Search Results - "Franklin, R J M"

Debris clearance by microglia: an essential link between degeneration and regeneration by Neumann, H., Kotter, M. R., Franklin, R. J. M.

“…Microglia are cells of myeloid origin that populate the CNS during early development and form the brain's innate immune cell type. They perform homoeostatic…”
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Polyornithine-based polyplexes to boost effective gene silencing in CNS disorders by Conejos-Sánchez, I, Gallon, E, Niño-Pariente, A, Smith, J A, De la Fuente, A G, Di Canio, L, Pluchino, S, Franklin, R J M, Vicent, M J

“…Gene silencing therapies have successfully suppressed the translation of target proteins, a strategy that holds great promise for the treatment of central…”
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Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis by Anderson, J. M., Hampton, D. W., Patani, R., Pryce, G., Crowther, R. A., Reynolds, R., Franklin, R. J. M., Giovannoni, G., Compston, D. A. S., Baker, D., Spillantini, M. G., Chandran, S.

“…The pathological correlate of clinical disability and progression in multiple sclerosis is neuronal and axonal loss; however, the underlying mechanisms are…”
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Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen by Stacpoole, S R L, Bilican, B, Webber, D J, Luzhynskaya, A, He, X L, Compston, A, Karadottir, R, Franklin, R J M, Chandran, S

“…This protocol has been designed to generate neural precursor cells (NPCs) from human embryonic stem cells (hESCs) using a physiological oxygen (O 2 ) level of…”
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Schwann cell precursors: a favourable cell for myelin repair in the Central Nervous System by Woodhoo, A., Sahni, V., Gilson, J., Setzu, A., Franklin, R.J.M, Blakemore, W.F., Mirsky, R., Jessen, K.R.

“…Cell transplant therapies are currently under active consideration for a number of degenerative diseases. In the immune-mediated…”
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Clinical canine spinal cord injury provides an opportunity to examine the issues in translating laboratory techniques into practical therapy by JEFFERY, N. D, SMITH, P. M, LAKATOS, A, IBANEZ, C, ITO, D, FRANKLIN, R. J. M

“…Review. To highlight the value of investigating the effects of putative therapeutic interventions in clinical spinal cord injury (SCI) in domestic dogs…”
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Systemic progesterone administration results in a partial reversal of the age-associated decline in CNS remyelination following toxin-induced demyelination in male rats by Ibanez, C., Shields, S. A., El-Etr, M., Baulieu, E.-E., Schumacher, M., Franklin, R. J. M.

“…In order to establish the effects of systemically administered progesterone on central nervous system (CNS) remyelination, a toxin‐induced model of CNS…”
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Remyelination in experimental models of toxin-induced demyelination by Blakemore, W F, Franklin, R J M

“…Remyelination is the regenerative process by which demyelinated axons are reinvested with new myelin sheaths. It is associated with functional recovery and…”
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Seeing is believing: Identifying remyelination in the central nervous system by Hill, M.F.E., Cunniffe, N.G., Franklin, R.J.M.

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Oligodendrocyte progenitors: Adult stem cells of the central nervous system? by Crawford, A.H., Stockley, J.H., Tripathi, R.B., Richardson, W.D., Franklin, R.J.M.

“…Oligodendrocyte progenitors (OPs) are a major proliferating cell population within the adult CNS. In response to myelin loss or increasing demand, OPs have the…”
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Remyelination: The True Regeneration of the Central Nervous System by Crawford, A.H., Chambers, C., Franklin, R.J.M.

“…The myelin sheath, generated by oligodendrocytes in the central nervous system (CNS), is crucial to neuronal function, enabling rapid propagation of nerve…”
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The responses of oligodendrocyte precursor cells, astrocytes and microglia to a cortical stab injury, in the brain by Hampton, D.W, Rhodes, K.E, Zhao, C, Franklin, R.J.M, Fawcett, J.W

“…The cortical stab injury has been widely used for biochemical analysis of molecular changes following CNS injury. However, the cellular responses to this…”
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Repair of demyelinated lesions by transplantation of purified 0-2A progenitor cells by Groves, A. K, Barnett, S. C, Franklin, R. J. M, Crang, A. J, Mayer, M, Blakemore, W. F, Noble, M

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Depletion of endogenous oligodendrocyte progenitors rather than increased availability of survival factors is a likely explanation for enhanced survival of transplanted oligodendrocyte progenitors in X-irradiated compared to normal CNS by Hinks, G. L., Chari, D. M., T. O'Leary, M., Zhao, C., Keirstead, H. S., Blakemore, W. F., Franklin, R. J. M.

“…Oligodendrocyte progenitors (OPs) survive and migrate following transplantation into adult rat central nervous system (CNS) exposed to high levels of…”
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Adenoviral vectors for in vivo gene delivery to oligodendrocytes : transgene expression and cytopathic consequences by FRANKLIN, R. J. M, QUICK, M. M, HAASE, G

“…Replication defective viral vectors provide a potentially useful means of gene transfer to oligodendrocytes and thus for studying the pathogenesis of white…”
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Cryopreserved Cells Isolated from the Adult Canine Olfactory Bulb Are Capable of Extensive Remyelination Following Transplantation into the Adult Rat CNS by Smith, P.M., Lakatos, A., Barnett, S.C., Jeffery, N.D., Franklin, R.J.M.

“…Naturally occurring spinal cord injury in dogs provides a potentially powerful intermediate model for testing the efficacy of therapeutic strategies developed…”
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Congenital Unilateral Absence of the Corticospinal Tract in a Siamese Cat by Palmer, A.C, Jeffery, N.D, Franklin, R.J.M

“…A Siamese kitten presented with mild gait dysfunction associated with periodic circling. Pathologic investigation revealed unilateral (right-sided) absence of…”
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Differentiation of the O-2A progenitor cell line CG-4 into oligodendrocytes and astrocytes following transplantation into glia-deficient areas of CNS white matter by Franklin, R J, Bayley, S A, Milner, R, Ffrench-Constant, C, Blakemore, W F

“…The in vitro properties of the CG4 cell line have led to its increasing use as a cell line with which to study the behaviour of the O-2A progenitor cell. In…”
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Promoting remyelination in multiple sclerosis by endogenous adult neural stem/precursor cells by Roulois, A J A, Zhao, C, Zawadzka, M, Bruce, C C, Franklin, R J M

“…Although the treatment of multiple sclerosis has made significant strides in the last decade, successful translation from laboratory to clinical medicine of…”
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Progressive encephalomyelopathy and cerebellar degeneration in 10 captive-bred cheetahs by Palmer, A. C., Callanan, J. J., Guerin, L. A., Sheahan, B. J., Franklin, R. J. M.

“…Progressive ataxia, with head tremor, developed in 10 captive-born cheetah cubs under six months of age. The condition was usually preceded by coryza and an…”
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