Search Results - "Franklin, Jeffrey L."

KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes by McKenzie, Andrew J., Hoshino, Daisuke, Hong, Nan Hyung, Cha, Diana J., Franklin, Jeffrey L., Coffey, Robert J., Patton, James G., Weaver, Alissa M.

“…Secretion of RNAs in extracellular vesicles is a newly recognized form of intercellular communication. A potential regulatory protein for microRNA (miRNA)…”
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The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor by Powell, Anne E., Wang, Yang, Li, Yina, Poulin, Emily J., Means, Anna L., Washington, Mary K., Higginbotham, James N., Juchheim, Alwin, Prasad, Nripesh, Levy, Shawn E., Guo, Yan, Shyr, Yu, Aronow, Bruce J., Haigis, Kevin M., Franklin, Jeffrey L., Coffey, Robert J.

“…Lineage mapping has identified both proliferative and quiescent intestinal stem cells, but the molecular circuitry controlling stem cell quiescence is…”
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Transfer of Functional Cargo in Exomeres by Zhang, Qin, Higginbotham, James N., Jeppesen, Dennis K., Yang, Yu-Ping, Li, Wei, McKinley, Eliot T., Graves-Deal, Ramona, Ping, Jie, Britain, Colleen M., Dorsett, Kaitlyn A., Hartman, Celine L., Ford, David A., Allen, Ryan M., Vickers, Kasey C., Liu, Qi, Franklin, Jeffrey L., Bellis, Susan L., Coffey, Robert J.

“…Exomeres are a recently discovered type of extracellular nanoparticle with no known biological function. Herein, we describe a simple ultracentrifugation-based…”
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Proteomic Analysis of Exosomes from Mutant KRAS Colon Cancer Cells Identifies Intercellular Transfer of Mutant KRAS by Demory Beckler, Michelle, Higginbotham, James N., Franklin, Jeffrey L., Ham, Amy-Joan, Halvey, Patrick J., Imasuen, Imade E., Whitwell, Corbin, Li, Ming, Liebler, Daniel C., Coffey, Robert J.

“…Activating mutations in KRAS occur in 30% to 40% of colorectal cancers. How mutant KRAS alters cancer cell behavior has been studied intensively, but non-cell…”
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Amphiregulin Exosomes Increase Cancer Cell Invasion by Higginbotham, James N., Demory Beckler, Michelle, Gephart, Jonathan D., Franklin, Jeffrey L., Bogatcheva, Galina, Kremers, Gert-Jan, Piston, David W., Ayers, Gregory D., McConnell, Russell E., Tyska, Matthew J., Coffey, Robert J.

“…Autocrine, paracrine, and juxtacrine are recognized modes of action for mammalian EGFR ligands including EGF, TGF-α (TGFα), amphiregulin (AREG),…”
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Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression by Liu, Hao, Li, Danxiu, Sun, Lina, Qin, Hongqiang, Fan, Ahui, Meng, Lingnan, Graves-Deal, Ramona, Glass, Sarah E, Franklin, Jeffrey L, Liu, Qi, Wang, Jing, Yeatman, Timothy J, Guo, Hao, Zong, Hong, Jin, Shuilin, Chen, Zhiyu, Deng, Ting, Fang, Ying, Li, Cunxi, Karijolich, John, Patton, James G, Wang, Xin, Nie, Yongzhan, Fan, Daiming, Coffey, Robert J, Zhao, Xiaodi, Lu, Yuanyuan

“…Abstract Background Epithelial-to-mesenchymal transition (EMT) is a process linked to metastasis and drug resistance with non-coding RNAs (ncRNAs) playing…”
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Quantitative Proteomic Analysis of Small and Large Extracellular Vesicles (EVs) Reveals Enrichment of Adhesion Proteins in Small EVs by Jimenez, Lizandra, Yu, Hui, McKenzie, Andrew J, Franklin, Jeffrey L, Patton, James G, Liu, Qi, Weaver, Alissa M

“…Extracellular vesicles (EVs) are important mediators of cell–cell communication due to their cargo content of proteins, lipids, and RNAs. We previously…”
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KRAS-dependent sorting of miRNA to exosomes by Cha, Diana J, Franklin, Jeffrey L, Dou, Yongchao, Liu, Qi, Higginbotham, James N, Demory Beckler, Michelle, Weaver, Alissa M, Vickers, Kasey, Prasad, Nirpesh, Levy, Shawn, Zhang, Bing, Coffey, Robert J, Patton, James G

“…Mutant KRAS colorectal cancer (CRC) cells release protein-laden exosomes that can alter the tumor microenvironment. To test whether exosomal RNAs also…”
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Diverse Long RNAs Are Differentially Sorted into Extracellular Vesicles Secreted by Colorectal Cancer Cells by Hinger, Scott A., Cha, Diana J., Franklin, Jeffrey L., Higginbotham, James N., Dou, Yongchao, Ping, Jie, Shu, Lihua, Prasad, Nripesh, Levy, Shawn, Zhang, Bing, Liu, Qi, Weaver, Alissa M., Coffey, Robert J., Patton, James G.

“…The regulation and functional roles of secreted coding and long noncoding RNAs (lncRNAs; >200 nt) are largely unknown. We previously showed that mutant KRAS…”
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A smooth muscle‐derived, Braf‐driven mouse model of gastrointestinal stromal tumor (GIST): evidence for an alternative GIST cell‐of‐origin by Kondo, Jumpei, Huh, Won Jae, Franklin, Jeffrey L, Heinrich, Michael C, Rubin, Brian P, Coffey, Robert J

“…Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the gut. GISTs are thought to arise solely from interstitial cells of Cajal…”
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Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex by Farrow, Melissa A., Chumbler, Nicole M., Lapierre, Lynne A., Franklin, Jeffrey L., Rutherford, Stacey A., Goldenring, James R., Lacy, D. Borden

“…Clostridium difficile infection (CDI) is a leading cause of health care-associated diarrhea and has increased in incidence and severity over the last decade…”
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Extracellular RNA in oncogenesis, metastasis and drug resistance by Nelson, Hannah, Qu, Sherman, Franklin, Jeffrey L, Liu, Qi, Pua, Heather H, Vickers, Kasey C, Weaver, Alissa M, Coffey, Robert J, Patton, James G

“…Extracellular vesicles and nanoparticles (EVPs) are now recognized as a novel form of cell-cell communication. All cells release a wide array of heterogeneous…”
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Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism by Chumbler, Nicole M, Farrow, Melissa A, Lapierre, Lynne A, Franklin, Jeffrey L, Haslam, David B, Haslam, David, Goldenring, James R, Lacy, D Borden

“…Clostridium difficile is the most common cause of antibiotic-associated nosocomial infection in the United States. C. difficile secretes two homologous toxins,…”
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Identification and characterization of EGF receptor in individual exosomes by fluorescence-activated vesicle sorting by Higginbotham, James N., Zhang, Qin, Jeppesen, Dennis K., Scott, Andrew M., Manning, H. Charles, Ochieng, Josiah, Franklin, Jeffrey L., Coffey, Robert J.

“…Exosomes are small, 40-130 nm secreted extracellular vesicles that recently have become the subject of intense focus as agents of intercellular communication,…”
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Extracellular vesicles and nanoparticles: emerging complexities by Jeppesen, Dennis K., Zhang, Qin, Franklin, Jeffrey L., Coffey, Robert J.

“…Research from the past few years has overturned our understanding of the field of extracellular vesicles (EVs) and nanoparticles (NPs) by demonstrating a much…”
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A Chimeric Egfr Protein Reporter Mouse Reveals Egfr Localization and Trafficking In Vivo by Yang, Yu-Ping, Ma, Haiting, Starchenko, Alina, Huh, Won Jae, Li, Wei, Hickman, F. Edward, Zhang, Qin, Franklin, Jeffrey L., Mortlock, Douglas P., Fuhrmann, Sabine, Carter, Bruce D., Ihrie, Rebecca A., Coffey, Robert J.

“…EGF receptor (EGFR) is a critical signaling node throughout life. However, it has not been possible to directly visualize endogenous Egfr in mice. Using…”
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LRIG1 Regulates Ontogeny of Smooth Muscle−Derived Subsets of Interstitial Cells of Cajal in Mice by Kondo, Jumpei, Powell, Anne E, Wang, Yang, Musser, Melissa A, Southard-Smith, E. Michelle, Franklin, Jeffrey L, Coffey, Robert J

“…Background & Aims Interstitial cells of Cajal (ICC) control intestinal smooth muscle contraction to regulate gut motility. ICC within the plane of the…”
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Cytometry‐based single‐cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF‐α‐induced apoptosis in vivo by Simmons, Alan J, Banerjee, Amrita, McKinley, Eliot T, Scurrah, Cherie' R, Herring, Charles A, Gewin, Leslie S, Masuzaki, Ryota, Karp, Seth J, Franklin, Jeffrey L, Gerdes, Michael J, Irish, Jonathan M, Coffey, Robert J, Lau, Ken S

“…Understanding heterogeneous cellular behaviors in a complex tissue requires the evaluation of signaling networks at single‐cell resolution. However, probing…”
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Electrodeposited magnetic nanoporous membrane for high-yield and high-throughput immunocapture of extracellular vesicles and lipoproteins by Zhang, Chenguang, Huo, Xiaoye, Zhu, Yini, Higginbotham, James N., Cao, Zheng, Lu, Xin, Franklin, Jeffrey L., Vickers, Kasey C., Coffey, Robert J., Senapati, Satyajyoti, Wang, Ceming, Chang, Hsueh-Chia

“…Superparamagnetic nanobeads offer several advantages over microbeads for immunocapture of nanocarriers (extracellular vesicles, lipoproteins, and viruses) in a…”
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An anion exchange membrane sensor detects EGFR and its activity state in plasma CD63 extracellular vesicles from patients with glioblastoma by Maniya, Nalin H., Kumar, Sonu, Franklin, Jeffrey L., Higginbotham, James N., Scott, Andrew M., Gan, Hui K., Coffey, Robert J., Senapati, Satyajyoti, Chang, Hsueh-Chia

“…We present a quantitative sandwich immunoassay for CD63 Extracellular Vesicles (EVs) and a constituent surface cargo, EGFR and its activity state, that…”
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