Search Results - "Frankfurt, O S"

Identification of Apoptotic Cells by Formamide-induced DNA Denaturation in Condensed Chromatin by Frankfurt, Oskar S, Krishan, Awtar

“…In this article we describe a novel effect of formamide on DNA of apoptotic nuclei and present a method for specific detection of apoptotic cells based on this…”
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Apoptosis in breast carcinomas detected with monoclonal antibody to single-stranded DNA: relation to bcl-2 expression, hormone receptors, and lymph node metastases by FRANKFURT, O. S, ROBB, J. A, SUGARBAKER, E. V, VILLA, L

“…Precise quantitation of apoptotic cells in solid tumors is necessary to determine the role of apoptosis in cancer growth, prognosis, and treatment. In this…”
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Detection of apoptosis in leukemic and breast cancer cells with monoclonal antibody to single-stranded DNA by Frankfurt, O S

“…In cultures of leukemic HL-60 and MOLT-4 cells treated with etoposide all nuclei with distinctive morphology of apoptosis (chromatin condensation at the…”
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Synergistic induction of apoptosis in breast cancer cells by tamoxifen and calmodulin inhibitors by Frankfurt, Oskar S., Sugarbaker, Everett V., Robb, James A., Villa, Luis

“…Breast cancer cells are relatively resistant to the induction of apoptosis (AP) and drug regimens which readily activate apoptotic death, may enhance the…”
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Inhibition of DNA repair and the enhancement of cytotoxicity of alkylating agents by Frankfurt, O S

“…DNA damage was evaluated by flow cytometric (FCM) analysis of cells treated with L-phenylalanine mustard (L-PAM) and stained with anti-DNA monoclonal antibody…”
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Protection from apoptotic cell death by interleukin-4 is increased in previously treated chronic lymphocytic leukemia patients by Frankfurt, Oskar S., Byrnes, John J., Villa, Luis

“…Chronic lymphocytic leukemia (CLL) cells were cultured in a medium supplemented with 0.01-1 ng/ml interleukin-4 (IL-4) for 18 h, fixed and analyzed on a flow…”
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Inhibition of DNA repair in cells treated with a combination of alkylating agents by Frankfurt, O S, Seckinger, D, Sugarbaker, E V

“…Aphidicolin (AP) or hydroxyurea (HU) inhibited DNA repair and enhanced cytotoxicity in human ovarian carcinoma cells A2780 treated with L-phenylalanine mustard…”
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Monoclonal Antibody to Single-Stranded DNA Is a Specific and Sensitive Cellular Marker of Apoptosis by Frankfurt, Oskar S., Robb, James A., Sugarbaker, Everett V., Villa, Luis

“…The most widely used histochemical marker of apoptosis (in situend labeling, TUNEL) detects both apoptotic and necrotic cells and evaluates only late stages of…”
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Decreased stability of DNA in cells treated with alkylating agents by Frankfurt, O S

“…A modified highly sensitive procedure for the evaluation of DNA damage in individual cells treated with alkylating agents is reported. The new methodology is…”
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Flow cytometric deoxyribonucleic acid analysis of primary and metastatic human renal cell carcinoma by Chin, J L, Pontes, J E, Frankfurt, O S

“…The deoxyribonucleic acid profiles of 54 renal cell carcinoma specimens (43 primary and 11 metastatic tumors) from 50 patients are reported. Deoxyribonucleic…”
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Apoptosis in human breast and gastrointestinal carcinomas. Detection in histological sections with monoclonal antibody to single-stranded DNA by Frankfurt, O S, Robb, J A, Sugarbaker, E V, Villa, L

“…We report application of a novel immunohistochemical procedure for the staining of apoptotic (AP) cells in paraffin sections using monoclonal antibody (MAb) to…”
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Immunoassay for single-stranded DNA in apoptotic cells by Frankfurt, O S

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Intercellular transfer of drug resistance by FRANKFURT, O. S, SECKINGER, D, SUGARBAKER, E. V

“…The effect of L-phenylalanine mustard (L-PAM) on heterogeneous cell populations containing sensitive and resistant cells was evaluated by flow cytometric…”
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Relationship between DNA ploidy, glandular differentiation, and tumor spread in human prostate cancer by FRANKFURT, O. S, CHIN, J. L, ENGLANDER, L. S, GRECO, W. R, PONTES, J. E, RUSTUM, Y. M

“…DNA ploidy was evaluated by flow cytometry for 45 human prostate carcinomas (34 prostatectomy specimens and 11 biopsies). Twenty tumors (44.4%) contained a…”
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Flow cytometric screening for selective toxicity to multidrug-resistant cells by Frankfurt, O S

“…Mixed cultures originally containing doxorubicin [(DOX) NCS-123127]-sensitive leukemia P388 (P388/S) cells and DOX-resistant leukemia P388 (P388/R) cells were…”
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Detection of DNA damage in individual cells by flow cytometric analysis using anti-DNA monoclonal antibody by Frankfurt, O S

“…A new method for the measurement of DNA damage in individual cells treated with alkylating agents is described. The method is based on the binding of anti-DNA…”
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Flow cytometry analysis of DNA damage and the evaluation of cytotoxicity of alkylating agents by FRANKFURT, O. S

“…Monoclonal antibody (MAb) F7-26 generated against nitrogen mustard (HN2)-treated DNA (O.S. Frankfurt, Exp. Cell Res., 170: 369-380, 1987) reacted with regions…”
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Enzyme-linked immunosorbent assay (ELISA) for the specific detection of apoptotic cells and its application to rapid drug screening by Frankfurt, Oskar S., Krishan, Awtar

“…We have developed a solid-phase ELISA for the specific and sensitive detection of apoptotic cells. This method is based on the ability of a monoclonal antibody…”
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Flow cytometric analysis of double-stranded RNA content distributions by Frankfurt, OS

“…A staining procedure is described for quantitative analysis of cellular RNA content distributions by flow cytometry (FCM). Cells were fixed in ethanol, treated…”
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Apoptosis (programmed cell death) and the evaluation of chemosensitivity in chronic lymphocytic leukemia and lymphoma by Frankfurt, O S, Byrnes, J J, Seckinger, D, Sugarbaker, E V

“…Chronic lymphocytic leukemia and lymphoma cells were treated with antitumor drugs in vitro and analyzed by flow cytometry to measure the number of apoptotic…”
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