Search Results - "Franken, N A"

The alfa and beta of tumours: a review of parameters of the linear-quadratic model, derived from clinical radiotherapy studies by van Leeuwen, C M, Oei, A L, Crezee, J, Bel, A, Franken, N A P, Stalpers, L J A, Kok, H P

“…Prediction of radiobiological response is a major challenge in radiotherapy. Of several radiobiological models, the linear-quadratic (LQ) model has been best…”
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Chromatin mobility is increased at sites of DNA double-strand breaks by Krawczyk, P M, Borovski, T, Stap, J, Cijsouw, T, ten Cate, R, Medema, J P, Kanaar, R, Franken, N A P, Aten, J A

“…DNA double-strand breaks (DSBs) can efficiently kill cancer cells, but they can also produce unwanted chromosome rearrangements when DNA ends from different…”
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Biological modelling of the radiation dose escalation effect of regional hyperthermia in cervical cancer by Crezee, J, van Leeuwen, C M, Oei, A L, van Heerden, L E, Bel, A, Stalpers, L J A, Ghadjar, P, Franken, N A P, Kok, H P

“…Locoregional hyperthermia combined with radiotherapy significantly improves locoregional control and overall survival for cervical tumors compared to…”
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Molecular and biological rationale of hyperthermia as radio- and chemosensitizer by Oei, A.L., Kok, H.P., Oei, S.B., Horsman, M.R., Stalpers, L.J.A., Franken, N.A.P., Crezee, J.

“…Mild hyperthermia, local heating of the tumour up to temperatures <43 °C, has been clinically applied for almost four decades and has been proven to…”
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Hyperthermia, cisplatin and radiation trimodality treatment: a promising cancer treatment? A review from preclinical studies to clinical application by Bergs, J W J, Franken, N A P, Haveman, J, Geijsen, E D, Crezee, J, van Bree, C

“…This review discusses available clinical and experimental data and the underlying mechanisms involved in trimodality treatment consisting of hyperthermia,…”
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The effect of time interval between radiotherapy and hyperthermia on planned equivalent radiation dose by van Leeuwen, C M, Crezee, J, Oei, A L, Franken, N A P, Stalpers, L J A, Bel, A, Kok, H P

“…Thermoradiotherapy is an effective treatment for locally advanced cervical cancer. However, the optimal time interval between radiotherapy and hyperthermia,…”
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Measurement and analysis of the impact of time-interval, temperature and radiation dose on tumour cell survival and its application in thermoradiotherapy plan evaluation by van Leeuwen, C M, Oei, A L, Ten Cate, R, Franken, N A P, Bel, A, Stalpers, L J A, Crezee, J, Kok, H P

“…Biological modelling of thermoradiotherapy may further improve patient selection and treatment plan optimisation, but requires a model that describes the…”
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Time course of enhanced activity of deoxycytidine kinase and thymidine kinase 1 and 2 in cultured human squamous lung carcinoma cells, SW-1573, induced by γ-irradiation by HAVEMAN, J, SIGMOND, J, VAN BREE, C, FRANKEN, N. A, KOEDOODER, C, PETERS, G. J

“…Single high dose rate irradiation of 4 Gy in SW-1573 cells, derived from non-small cell lung cancer, led to increased activities of deoxycytidine kinase (dCK)…”
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Quantitative analysis of contribution of mild and moderate hyperthermia to thermal ablation and sensitization of irreversible electroporation of pancreatic cancer cells by Agnass, P., Rodermond, H.M., van Veldhuisen, E., Vogel, J.A., ten Cate, R., van Lienden, K.P., van Gulik, T.M., Franken, N.A.P., Oei, A.L., Kok, H.P., Besselink, M.G., Crezee, J.

“…Irreversible electroporation (IRE) is an ablation modality that applies short, high-voltage electric pulses to unresectable cancers. Although considered a…”
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Differential Response to Radiation of TP53-Inactivated Cells by Overexpression of Dominant-Negative Mutant TP53 or HPVE6 by Franken, N. A P., van Bree, C., Haveman, J.

“…Franken, N. A. P., van Bree, C. and Haveman, J. Differential Response to Radiation of TP53-Inactivated Cells by Overexpression of Dominant-Negative Mutant TP53…”
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Importance of TP53 and RB in the Repair of Potentially Lethal Damage and Induction of Color Junctions after Exposure to Ionizing Radiation by Franken, N. A P., van Bree, C., ten Cate, R., van Oven, C. H., Haveman, J.

“…Franken, N. A. P., van Bree, C., ten Cate, R., van Oven, C. H. and Haveman, J. Importance of TP53 and RB in the Repair of Potentially Lethal Damage and…”
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Cellular Response to Pulsed Low-dose Rate Irradiation in X-ray Sensitive Hamster Mutant Cell Lines by Kreder, N Castro, ten Cate, R, Rodermond, H M, van Bree, C, Franken, N A P, Zdzienicka, M Z, Haveman, J

“…The role of DNA repair mechanisms in the cellular response to low dose rate (LDR) irradiation was studied with the aim to gain insight in the process of…”
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Repair of Potentially Lethal Damage does not Depend on Functional TP53 in Human Glioblastoma Cells by van Bree, C., Franken, N. A P., Rodermond, H. M., Stalpers, L. J A., Haveman, J.

“…van Bree, C., Franken, N. A. P., Rodermond, H. M., Stalpers, L. J. A. and Haveman, J. Repair of Potentially Lethal Damage does not Depend on Functional TP53 in…”
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Outcome of a rabbit model for late irradiation effects in mandibular oral mucosa and bone: A pilot study by Helmers, R, Milstein, D M J, Straat, N F, Rodermond, H M, Franken, N A P, Savci-Heijink, C D, de Boer, H H, de Lange, J

“…Late side effects of radiotherapy (RT) in the treatment for head and neck (HN) malignancies involve an inadequate healing response of the distressed tissue due…”
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Myocardial enzyme activities in plasma after whole-heart irradiation in rats by FRANKEN, N. A. P, STROOTMAN, E, HOLLAAR, L, VAN DER LAARSE, A, WONDERGEM, J

“…Plasma levels of myocardial enzymes present after local heart irradiation were studied in a rat model. The purpose was to investigate whether, within days…”
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Correlation between cell reproductive death and chromosome aberrations assessed by FISH for low and high doses of radiation and sensitization by iodo-deoxyuridine in human SW-1573 cells by FRANKEN, N. A. P.

“…Purpose : To study the relationship between cell reproductive death and exchange frequency in SW-1573 human lung tumour cells with and without incorporated…”
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Induction of chromosome aberrations in unirradiated chromatin after partial irradiation of a cell nucleus by Ludwików, G., Xiao, Yun, Hoebe, R. A., Franken, N. A. P., Darroudi, F., Stap, J., Oven, C. H. Van, Noorden, C. J. F. Van, Aten, J. A.

“…Purpose : It is generally accepted that chromosome exchanges in irradiated cells are formed through interactions between separate DNA double-strand breaks…”
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The effect of p53-function on the sensitivity to paclitaxel with or without hyperthermia in human colorectal carcinoma cells by van Bree, C, Savonije, J H, Franken, N A, Haveman, J, Bakker, P J

“…The importance of p53-function for the sensitivity to paclitaxel with and without hyperthermia (HT) was studied in an isogenic cell line system. The…”
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Chromosome aberrations detected by FISH and correlation with cell survival after irradiation at various dose-rates and after bromodeoxyuridine radiosensitization by Kreder, N. Castro, Bree, C. Van, Franken, N. A. P., Haveman, J.

“…Purpose : To determine whether measurement of chromosome aberrations by fluorescence in situ hybridization (FISH) predicts cell survival after irradiation at…”
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Wild-type p53-function is not required for hyperthermia-enhanced cytotoxicity of cisplatin by van Bree, C, Franken, N A, Snel, F A, Haveman, J, Bakker, P J

“…The objective was to test the hypothesis that wild-type p53-function is required for the enhancement of the cytotoxicity of cis-diammine-dichloroplatinum(II)…”
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