Search Results - "Frank Diehl"

Performance of Streck cfDNA Blood Collection Tubes for Liquid Biopsy Testing by Medina Diaz, Inga, Nocon, Annette, Mehnert, Daniel H, Fredebohm, Johannes, Diehl, Frank, Holtrup, Frank

“…Making liquid biopsy testing widely available requires a concept to ship whole blood at ambient temperatures while retaining the integrity of the cell-free DNA…”
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Circulating mutant DNA to assess tumor dynamics by Sokoll, Lori, Li, Meng, Agrawal, Nishant, Thornton, Katherine, Schmidt, Kerstin, Szabo, Steve A, Vogelstein, Bert, Diaz Jr, Luis A, Diehl, Frank, Romans, Katharine, Choti, Michael A, Goodman, Steven, Kinzler, Kenneth W

“…The measurement of circulating nucleic acids has transformed the management of chronic viral infections such as HIV. The development of analogous markers for…”
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Comparative lesion sequencing provides insights into tumor evolution by Jones, Siân, Chen, Wei-dong, Parmigiani, Giovanni, Diehl, Frank, Beerenwinkel, Niko, Antal, Tibor, Traulsen, Arne, Nowak, Martin A, Siegel, Christopher, Velculescu, Victor E, Kinzler, Kenneth W, Vogelstein, Bert, Willis, Joseph, Markowitz, Sanford D

“…We show that the times separating the birth of benign, invasive, and metastatic tumor cells can be determined by analysis of the mutations they have in common…”
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Detection of Tumor PIK3CA Status in Metastatic Breast Cancer Using Peripheral Blood by HIGGINS, Michaela J, JELOVAC, Danijela, EMENS, Leisha, RILEY, Carol, STEARNS, Vered, DIEHL, Frank, ANGENENDT, Philipp, PENG HUANG, COPE, Leslie, ARGANI, Pedram, MURPHY, Kathleen M, BACHMAN, Kurtis E, BARNATHAN, Evan, GRESHOCK, Joel, WOLFF, Antonio C, PARK, Ben H, BLAIR, Brian, SLATER, Shannon, POWERS, Penny, ZORZI, Jane, JETER, Stacie C, OLIVER, George R, FETTING, John

“…We sought to evaluate the feasibility of detecting PIK3CA mutations in circulating tumor DNA (ctDNA) from plasma of patients with metastatic breast cancer…”
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BEAMing: single-molecule PCR on microparticles in water-in-oil emulsions by Vogelstein, Bert, Diehl, Frank, Li, Meng, He, Yiping, Kinzler, Kenneth W, Dressman, Devin

“…BEAMing (beads, emulsions, amplification and magnetics) is a process built on emulsion PCR that (i) includes beads within the compartments and (ii) ensures…”
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Development of personalized tumor biomarkers using massively parallel sequencing by Leary, Rebecca J, Kinde, Isaac, Diehl, Frank, Schmidt, Kerstin, Clouser, Chris, Duncan, Cisilya, Antipova, Alena, Lee, Clarence, McKernan, Kevin, De La Vega, Francisco M, Kinzler, Kenneth W, Vogelstein, Bert, Diaz, Jr, Luis A, Velculescu, Victor E

“…Clinical management of human cancer is dependent on the accurate monitoring of residual and recurrent tumors. The evaluation of patient-specific translocations…”
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Detection and Quantification of Mutations in the Plasma of Patients with Colorectal Tumors by Frank Diehl, Li, Meng, Dressman, Devin, He, Yiping, Shen, Dong, Szabo, Steve, Luis A. Diaz, Jr, Goodman, Steven N., Kerstin A. David, Juhl, Hartmut, Kinzler, Kenneth W., Vogelstein, Bert

“…The early detection of cancers through analysis of circulating DNA could have a substantial impact on morbidity and mortality. To achieve this goal, it is…”
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Combined targeting of AKT and mTOR using MK‐2206 and RAD001 is synergistic in the treatment of cholangiocarcinoma by Ewald, Florian, Grabinski, Nicole, Grottke, Astrid, Windhorst, Sabine, Nörz, Dominik, Carstensen, Lisa, Staufer, Katharina, Hofmann, Bianca T., Diehl, Frank, David, Kerstin, Schumacher, Udo, Nashan, Björn, Jücker, Manfred

“…Cholangiocarcinoma (CCA) is a rare, but devastating disease arising from the epithelium of intrahepatic and extrahepatic bile ducts. There are neither…”
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Analysis of Mutations in DNA Isolated From Plasma and Stool of Colorectal Cancer Patients by Diehl, Frank, Schmidt, Kerstin, Durkee, Kristine H, Moore, Kent J, Goodman, Steve N, Shuber, Anthony P, Kinzler, Kenneth W, Vogelstein, Bert

“…Background & Aims: Somatic mutations provide uniquely specific markers for the early detection of neoplasia that can be detected in DNA purified from plasma or…”
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BEAMing up for detection and quantification of rare sequence variants by Vogelstein, Bert, Kinzler, Kenneth W, Li, Meng, Diehl, Frank, Dressman, Devin

“…BEAMing allows the one-to-one conversion of a population of DNA fragments into a population of beads. We used rolling circle amplification to increase the…”
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Pre-malignant conditions diagnosed following a positive cancer signal from a multi-cancer early detection test by Choudhry, Omair A., Kharge, Angana B., Rego, Seema P., Elias, Paul Z., Buchanan, Adam H., Lennon, Anne Marie, Papadopoulos, Nickolas, Diehl, Frank, Beer, Tomasz M.

“…Blood-based tests for multi-cancer early detection (MCED) are being developed to facilitate the detection of various cancer types. The Detecting cancers…”
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Pre-Analytical Evaluation of Streck Cell-Free DNA Blood Collection Tubes for Liquid Profiling in Oncology by Diaz, Inga Medina, Nocon, Annette, Held, Stefanie A E, Kobilay, Makbule, Skowasch, Dirk, Bronkhorst, Abel J, Ungerer, Vida, Fredebohm, Johannes, Diehl, Frank, Holdenrieder, Stefan, Holtrup, Frank

“…Excellent pre-analytical stability is an essential precondition for reliable molecular profiling of circulating tumor DNA (ctDNA) in oncological diagnostics…”
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Serial assessment of human tumor burdens in mice by the analysis of circulating DNA by RAGO, Carlo, HUSO, David L, DIAZ, Luis A, DIEHL, Frank, KARIM, Baktiar, GUOSHENG LIU, PAPADOPOULOS, Nickolas, SAMUELS, Yardena, VELCULESCU, Victor E, VOGELSTEIN, Bert, KINZLER, Kenneth W

“…Internal human xenografts provide valuable animal models to study the microenvironments and metastatic processes occurring in human cancers. However, the use…”
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Antibody microarrays: An evaluation of production parameters by Kusnezow, Wlad, Jacob, Anette, Walijew, Alexandra, Diehl, Frank, Hoheisel, Jörg D.

“…Antibody microarrays could have an enormous impact on the functional analysis of cellular activity and regulation, especially at the level of protein…”
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Detection of Tumor DNA at the Margins of Colorectal Cancer Liver Metastasis by HOLDHOFF, Matthias, SCHMIDT, Kerstin, CHOTI, Michael A, DIAZ, Luis A, DIEHL, Frank, AGGRAWAL, Nishant, ANGENENDT, Philipp, ROMANS, Katharine, EDELSTEIN, Daniel L, TORBENSON, Michael, KINZLER, Kenneth W, VOGELSTEIN, Bert

“…Defining an adequate resection margin of colorectal cancer liver metastases is essential for optimizing surgical technique. We have attempted to evaluate the…”
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Human Papillomavirus Type 16 E6 Promotes Retinoblastoma Protein Phosphorylation and Cell Cycle Progression by MALANCHI, Ilaria, ACCARDI, Rosita, DIEHL, Frank, SMET, Anouk, ANDROPHY, Elliot, HOHEISEL, Jörg, TOMMASINO, Massimo

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Digital quantification of mutant DNA in cancer patients by Diehl, Frank, Diaz, Luis A

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Towards systematic nomenclature for cell-free DNA by Bronkhorst, Abel J., Ungerer, Vida, Diehl, Frank, Anker, Philippe, Dor, Yuval, Fleischhacker, Michael, Gahan, Peter B., Hui, Lisa, Holdenrieder, Stefan, Thierry, Alain R.

“…Cell-free DNA (cfDNA) has become widely recognized as a promising candidate biomarker for minimally invasive characterization of various genomic disorders and…”
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Sensitive digital quantification of DNA methylation in clinical samples by Markowitz, Sanford D, Li, Meng, Chen, Wei-dong, Papadopoulos, Nickolas, Goodman, Steven N, Bjerregaard, Niels Christian, Laurberg, Søren, Levin, Bernard, Juhl, Hartmut, Arber, Nadir, Moinova, Helen, Durkee, Kris, Schmidt, Kerstin, He, Yiping, Diehl, Frank, Velculescu, Victor E, Zhou, Shibin, Diaz, Luis A, Kinzler, Kenneth W, Vogelstein, Bert

“…Analysis of abnormally methylated genes is increasingly important in basic research and in the development of cancer biomarkers. We have developed…”
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Abstract IA023: Improved sensitivity of a multi-analyte early detection test based on mutation, methylation, aneuploidy, and protein biomarkers by Gianullin, Vladimir, Hagmann, Leonardo, Arvai, Kevin, Djebbari, Amira, Nobles, Christopher L., Hogstrom, Larson, Manesse, Mael, Fa, Vuna, Zhuang, Fanglei, Chen, Xi, Katerov, Viatcheslav E., Garces, Jorge, Allawi, Hatim T., McElhinny, Abigail, Diehl, Frank, Cerqueira, Gustavo C

“…Abstract Background: A multi-analyte blood test has the potential to maximize performance for early detection across different cancer stages and types…”
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