Search Results - "Frank, Stephan"

Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics by Schmitt, Karen, Grimm, Amandine, Dallmann, Robert, Oettinghaus, Bjoern, Restelli, Lisa Michelle, Witzig, Melissa, Ishihara, Naotada, Mihara, Katsuyoshi, Ripperger, Jürgen A., Albrecht, Urs, Frank, Stephan, Brown, Steven A., Eckert, Anne

“…Mitochondrial fission-fusion dynamics and mitochondrial bioenergetics, including oxidative phosphorylation and generation of ATP, are strongly…”
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Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes by Shahmoradian, Sarah H., Lewis, Amanda J., Genoud, Christel, Hench, Jürgen, Moors, Tim E., Navarro, Paula P., Castaño-Díez, Daniel, Schweighauser, Gabriel, Graff-Meyer, Alexandra, Goldie, Kenneth N., Sütterlin, Rosmarie, Huisman, Evelien, Ingrassia, Angela, Gier, Yvonne de, Rozemuller, Annemieke J. M., Wang, Jing, Paepe, Anne De, Erny, Johannes, Staempfli, Andreas, Hoernschemeyer, Joerg, Großerüschkamp, Frederik, Niedieker, Daniel, El-Mashtoly, Samir F., Quadri, Marialuisa, Van IJcken, Wilfred F. J., Bonifati, Vincenzo, Gerwert, Klaus, Bohrmann, Bernd, Frank, Stephan, Britschgi, Markus, Stahlberg, Henning, Van de Berg, Wilma D. J., Lauer, Matthias E.

“…Parkinson’s disease, the most common age-related movement disorder, is a progressive neurodegenerative disease with unclear etiology. Key neuropathological…”
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Brain homogenates from human tauopathies induce tau inclusions in mouse brain by Clavaguera, Florence, Akatsu, Hiroyasu, Fraser, Graham, Crowther, R. Anthony, Frank, Stephan, Hench, Jürgen, Probst, Alphonse, Winkler, David T., Reichwald, Julia, Staufenbiel, Matthias, Ghetti, Bernardino, Goedert, Michel, Tolnay, Markus

“…Filamentous inclusions made of hyperphosphorylated tau are characteristic of numerous human neurodegenerative diseases, including Alzheimer’s disease,…”
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Transmission and spreading of tauopathy in transgenic mouse brain by Crowther, R. Anthony, Clavaguera, Florence, Abramowski, Dorothee, Goedert, Michel, Bolmont, Tristan, Probst, Alphonse, Tolnay, Markus, Fraser, Graham, Staufenbiel, Matthias, Stalder, Anna K, Jucker, Mathias, Beibel, Martin, Frank, Stephan

“…Hyperphosphorylated tau makes up the filamentous intracellular inclusions of several neurodegenerative diseases, including Alzheimer's disease. In the disease…”
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Shaping mitochondria: The complex posttranslational regulation of the mitochondrial fission protein DRP1 by Santel, Ansgar, Frank, Stephan

“…Mitochondria are essential and dynamic cellular organelles differing in size, subcellular distribution, and internal structure. These aspects of mitochondrial…”
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Differential retrotranslocation of mitochondrial Bax and Bak by Todt, Franziska, Cakir, Zeynep, Reichenbach, Frank, Emschermann, Frederic, Lauterwasser, Joachim, Kaiser, Andrea, Ichim, Gabriel, Tait, Stephen WG, Frank, Stephan, Langer, Harald F, Edlich, Frank

“…The Bcl‐2 proteins Bax and Bak can permeabilize the outer mitochondrial membrane and commit cells to apoptosis. Pro‐survival Bcl‐2 proteins control Bax by…”
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Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy by Castets, Perrine, Lin, Shuo, Rion, Nathalie, Di Fulvio, Sabrina, Romanino, Klaas, Guridi, Maitea, Frank, Stephan, Tintignac, Lionel A., Sinnreich, Michael, Rüegg, Markus A.

“…Autophagy is a catabolic process that ensures homeostatic cell clearance and is deregulated in a growing number of myopathological conditions. Although FoxO3…”
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"Prion-Like" Templated Misfolding in Tauopathies by Clavaguera, Florence, Lavenir, Isabelle, Falcon, Ben, Frank, Stephan, Goedert, Michel, Tolnay, Markus

“…The soluble microtubule‐associated protein tau forms hyperphosphorylated, insoluble and filamentous inclusions in a number of neurodegenerative diseases…”
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An ordered approach to solving parity games in quasi-polynomial time and quasi-linear space by Fearnley, John, Jain, Sanjay, de Keijzer, Bart, Schewe, Sven, Stephan, Frank, Wojtczak, Dominik

“…Parity games play an important role in model checking and synthesis. In their paper, Calude et al. have recently shown that these games can be solved in…”
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Undertriage in older emergency department patients--tilting against windmills? by Grossmann, Florian F, Zumbrunn, Thomas, Ciprian, Sandro, Stephan, Frank-Peter, Woy, Natascha, Bingisser, Roland, Nickel, Christian H

“…The aim of this study was to investigate the long-term effect of a teaching intervention designed to reduce undertriage rates in older ED patients. Further, to…”
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A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR by Sievers, Philipp, Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Reuss, David E, Sturm, Dominik, Hench, Jürgen, Frank, Stephan, Krskova, Lenka, Vicha, Ales, Zapotocky, Michal, Bison, Brigitte, Castel, David, Grill, Jacques, Debily, Marie-Anne, Harter, Patrick N, Snuderl, Matija, Kramm, Christof M, Reifenberger, Guido, Korshunov, Andrey, Jabado, Nada, Wesseling, Pieter, Wick, Wolfgang, Solomon, David A, Perry, Arie, Jacques, Thomas S, Jones, Chris, Witt, Olaf, Pfister, Stefan M, von Deimling, Andreas, Jones, David T W, Sahm, Felix

“…Abstract Background Malignant astrocytic gliomas in children show a remarkable biological and clinical diversity. Small in-frame insertions or missense…”
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Immunosuppressive effects of circulating bile acids in human endotoxemia and septic shock: patients with liver failure are at risk by Leonhardt, Julia, Dorresteijn, Mirrin J, Neugebauer, Sophie, Mihaylov, Diana, Kunze, Julia, Rubio, Ignacio, Hohberger, Frank-Stephan, Leonhardt, Silke, Kiehntopf, Michael, Stahl, Klaus, Bode, Christian, David, Sascha, Wagener, Frank A D T G, Pickkers, Peter, Bauer, Michael

“…Sepsis-induced immunosuppression is a frequent cause of opportunistic infections and death in critically ill patients. A better understanding of the underlying…”
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Peripheral administration of tau aggregates triggers intracerebral tauopathy in transgenic mice by Clavaguera, Florence, Hench, Jürgen, Lavenir, Isabelle, Schweighauser, Gabriel, Frank, Stephan, Goedert, Michel, Tolnay, Markus

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Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21 by Restelli, Lisa Michelle, Oettinghaus, Björn, Halliday, Mark, Agca, Cavit, Licci, Maria, Sironi, Lara, Savoia, Claudia, Hench, Jürgen, Tolnay, Markus, Neutzner, Albert, Schmidt, Alexander, Eckert, Anne, Mallucci, Giovanna, Scorrano, Luca, Frank, Stephan

“…Stress adaptation is essential for neuronal health. While the fundamental role of mitochondria in neuronal development has been demonstrated, it is still not…”
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CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10 by Huang, Xiaoping, Wu, Beverly P, Nguyen, Diana, Liu, Yi-Ting, Marani, Melika, Hench, Jürgen, Bénit, Paule, Kozjak-Pavlovic, Vera, Rustin, Pierre, Frank, Stephan, Narendra, Derek P

“…Abstract Mutations in paralogous mitochondrial proteins CHCHD2 and CHCHD10 cause autosomal dominant Parkinson Disease (PD) and Amyotrophic Lateral…”
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DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress by Oettinghaus, Björn, D'Alonzo, Donato, Barbieri, Elisa, Restelli, Lisa Michelle, Savoia, Claudia, Licci, Maria, Tolnay, Markus, Frank, Stephan, Scorrano, Luca

“…During apoptosis mitochondria undergo cristae remodeling and fragmentation, but how the latter relates to outer membrane permeabilization and downstream…”
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Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I by Brockhoff, Marielle, Rion, Nathalie, Chojnowska, Kathrin, Wiktorowicz, Tatiana, Eickhorst, Christopher, Erne, Beat, Frank, Stephan, Angelini, Corrado, Furling, Denis, Rüegg, Markus A, Sinnreich, Michael, Castets, Perrine

“…Myotonic dystrophy type I (DM1) is a disabling multisystemic disease that predominantly affects skeletal muscle. It is caused by expanded CTG repeats in the…”
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Generation of UV Ellipsoidal Pulses by 3D Amplitude Shaping for Application in High-Brightness Photoinjectors by Hoffmann, Andreas, Good, James, Gross, Matthias, Krasilnikov, Mikhail, Stephan, Frank

“…Photocathode laser pulse shaping is a crucial technology for enhancing the performance of X-ray free-electron lasers by optimizing the quality of electron…”
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A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes by Giachino, Claudio, Boulay, Jean-Louis, Ivanek, Robert, Alvarado, Alvaro, Tostado, Cristobal, Lugert, Sebastian, Tchorz, Jan, Coban, Mustafa, Mariani, Luigi, Bettler, Bernhard, Lathia, Justin, Frank, Stephan, Pfister, Stefan, Kool, Marcel, Taylor, Verdon

“…In the brain, Notch signaling maintains normal neural stem cells, but also brain cancer stem cells, indicating an oncogenic role. Here, we identify an…”
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Direct measurement of photocathode time response in a high-brightness photoinjector by Loisch, Gregor, Chen, Ye, Koschitzki, Christian, Qian, Houjun, Gross, Matthias, Hannah, Adrian, Hoffmann, Andreas, Kalantaryan, Davit, Krasilnikov, Mikhail, Lederer, Sven, Li, Xiangkun, Lishilin, Osip, Melkumyan, David, Monaco, Laura, Niemczyk, Raffael, Oppelt, Anne, Sertore, Daniele, Stephan, Frank, Valizadeh, Reza, Vashchenko, Grygorii, Weilbach, Tobias

“…Electron photoinjectors provide high-brightness electron beams to numerous research applications in physics, chemistry, material, and life sciences…”
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