Search Results - "Frank, René A W"

The in-tissue molecular architecture of β-amyloid pathology in the mammalian brain by Leistner, Conny, Wilkinson, Martin, Burgess, Ailidh, Lovatt, Megan, Goodbody, Stanley, Xu, Yong, Deuchars, Susan, Radford, Sheena E., Ranson, Neil A., Frank, René A. W.

“…Amyloid plaques composed of Aβ fibrils are a hallmark of Alzheimer’s disease (AD). However, the molecular architecture of amyloid plaques in the context of…”
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A Molecular Switch and Proton Wire Synchronize the Active Sites in Thiamine Enzymes by René A. W. Frank, Titman, Christopher M., Pratap, J. Venkatesh, Luisi, Ben F., Perham, Richard N.

“…Thiamine diphosphate (ThDP) is used as a cofactor in many key metabolic enzymes. We present evidence that the ThDPs in the two active sites of the E1 (EC…”
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Pushing the limits in single particle cryo-EM: general discussion by Bakker, Saskia E, Bhella, David, Brescia, Rosaria, Bullough, Per, Clare, Daniel K, Daum, Bertram, Frank, René A W, Gold, Vicki A M, Jackson Hirst, Isobel, Kühlbrandt, Werner, Lu, Penghan, McLaren, Mathew, Menday, Rebbekah, Muench, Stephen P, Rauschenbach, Stephan, Russo, Christopher J, Saibil, Helen, Scheres, Sjors H W, Shah, Archna R, Smith, Corinne, Torpey, James, Zanetti, Giulia

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Map/model validation and machine learning in EM: general discussion by Bakker, Saskia E, Bergeron, Julien, Bharadwaj, Alok, Bhella, David, Bullough, Per, Chau, Pak-Lee, Frank, René A W, Jakobi, Arjen J, Joseph, Agnel Praveen, Kühlbrandt, Werner, Lahiri, Indrajit, Menday, Rebbekah, Muench, Stephen P, Nakasone, Mark, Nerukh, Dmitry, Paris, Giulia, Russo, Christopher J, Saibil, Helen R, Scheres, Sjors H W, Sehrawat, Vidhi, Shah, Archna R, Thorn, Andrea, Vilas, José Luis, Zanetti, Giulia

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Off-Pathway, Oxygen-Dependent Thiamine Radical in the Krebs Cycle by Frank, René A. W, Kay, Christopher W. M, Hirst, Judy, Luisi, Ben F

“…The catalytic cofactor thiamine diphosphate is found in many enzymes of central metabolism and is essential in all extant forms of life. We demonstrate the…”
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NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation by Frank, René A. W., Komiyama, Noboru H., Ryan, Tomás J., Zhu, Fei, O’Dell, Thomas J., Grant, Seth G. N.

“…How neuronal proteomes self-organize is poorly understood because of their inherent molecular and cellular complexity. Here, focusing on mammalian synapses we…”
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Bridging length scales from molecules to the whole organism by cryoCLEM and cryoET by Lovatt, Megan, Leistner, Conny, Frank, René A W

“…Resolving atomic structures of isolated proteins has uncovered mechanisms and fundamental processes in biology. However, many functions can only be tested in…”
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Sample preparation in single particle cryo-EM: general discussion by Al-Otaibi, Natalie, Aminian J, Atieh, Anane, Rex Frimpong, Baatsen, Pieter, Bakker, Saskia E, Bergeron, Julien, Bharadwaj, Alok, Bhella, David, Braun, Thomas, Brescia, Rosaria, Bullough, Per, Clare, Daniel K, Daum, Bertram, Esser, Tim K, Farinas Lucas, Irene Del Mar, Frank, René A W, Gold, Vicki A M, Harrison, Peter J, Hirst, Isobel Jackson, Klebl, David P, Kühlbrandt, Werner, Morton, Christopher, Muench, Stephen P, Nakasone, Mark, Russo, Christopher J, Saibil, Helen R, Scheres, Sjors H W, Sehrawat, Vidhi, Shah, Archna R, Smith, Corinne, Thompson, Rebecca F, Thorn, Andrea, Zanetti, Giulia

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Clustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorder by Frank, René A W, McRae, Allan F, Pocklington, Andrew J, van de Lagemaat, Louie N, Navarro, Pau, Croning, Mike D R, Komiyama, Noboru H, Bradley, Sophie J, Challiss, R A John, Armstrong, J Douglas, Finn, Robert D, Malloy, Mary P, MacLean, Alan W, Harris, Sarah E, Starr, John M, Bhaskar, Sanjeev S, Howard, Eleanor K, Hunt, Sarah E, Coffey, Alison J, Ranganath, Venkatesh, Deloukas, Panos, Rogers, Jane, Muir, Walter J, Deary, Ian J, Blackwood, Douglas H, Visscher, Peter M, Grant, Seth G N

“…Current models of schizophrenia and bipolar disorder implicate multiple genes, however their biological relationships remain elusive. To test the genetic role…”
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Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes by Frank, René A. W., Zhu, Fei, Komiyama, Noboru H, Grant, Seth G. N.

“…PSD95 is an abundant postsynaptic scaffold protein in glutamatergic synapses that assembles into supercomplexes composed of over 80 proteins including…”
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CryoET of β-amyloid and tau within postmortem Alzheimer’s disease brain by Gilbert, Madeleine A. G., Fatima, Nayab, Jenkins, Joshua, O’Sullivan, Thomas J., Schertel, Andreas, Halfon, Yehuda, Wilkinson, Martin, Morrema, Tjado H. J., Geibel, Mirjam, Read, Randy J., Ranson, Neil A., Radford, Sheena E., Hoozemans, Jeroen J. M., Frank, René A. W.

“…A defining pathological feature of most neurodegenerative diseases is the assembly of proteins into amyloid that form disease-specific structures 1 . In…”
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Supramolecular organization of NMDA receptors and the postsynaptic density by Frank, René AW, Grant, Seth GN

“…Highlights • Complexes, supercomplexes and nanodomains are building blocks of the synapse. • A tripartite mechanism dictates NMDA receptor complex assembly…”
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Crystal Structure of the E1 Component of the Escherichia coli 2-Oxoglutarate Dehydrogenase Multienzyme Complex by Frank, René A.W., Price, Amanda J., Northrop, Fred D., Perham, Richard N., Luisi, Ben F.

“…The thiamine-dependent E1o component (EC 1.2.4.2) of the 2-oxoglutarate dehydrogenase complex catalyses a rate-limiting step of the tricarboxylic acid cycle…”
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A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits by Almeida-Souza, Leonardo, Frank, Rene A.W., García-Nafría, Javier, Colussi, Adeline, Gunawardana, Nushan, Johnson, Christopher M., Yu, Minmin, Howard, Gillian, Andrews, Byron, Vallis, Yvonne, McMahon, Harvey T.

“…Multiple proteins act co-operatively in mammalian clathrin-mediated endocytosis (CME) to generate endocytic vesicles from the plasma membrane. The principles…”
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Multidimensional Dynamics of the Proteome in the Neurodegenerative and Aging Mammalian Brain by Andrews, Byron, Murphy, Alan E., Stofella, Michele, Maslen, Sarah, Almeida-Souza, Leonardo, Skehel, J. Mark, Skene, Nathan G., Sobott, Frank, Frank, René A.W.

“…The amount of any given protein in the brain is determined by the rates of its synthesis and destruction, which are regulated by different cellular mechanisms…”
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Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence by Fernández, Esperanza, Collins, Mark O., Frank, René A.W., Zhu, Fei, Kopanitsa, Maksym V., Nithianantharajah, Jess, Lemprière, Sarah A., Fricker, David, Elsegood, Kathryn A., McLaughlin, Catherine L., Croning, Mike D.R., Mclean, Colin, Armstrong, J. Douglas, Hill, W. David, Deary, Ian J., Cencelli, Giulia, Bagni, Claudia, Fromer, Menachem, Purcell, Shaun M., Pocklington, Andrew J., Choudhary, Jyoti S., Komiyama, Noboru H., Grant, Seth G.N.

“…Arc is an activity-regulated neuronal protein, but little is known about its interactions, assembly into multiprotein complexes, and role in human disease and…”
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Endogenous ion channel complexes: the NMDA receptor by Frank, René A W

“…Ionotropic receptors, including the NMDAR (N-methyl-D-aspartate receptor) mediate fast neurotransmission, neurodevelopment, neuronal excitability and learning…”
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Hierarchical organization and genetically separable subfamilies of PSD 95 postsynaptic supercomplexes by Frank, René A. W., Zhu, Fei, Komiyama, Noboru H, Grant, Seth G. N.

“…Abstract PSD 95 is an abundant postsynaptic scaffold protein in glutamatergic synapses that assembles into supercomplexes composed of over 80 proteins…”
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Snapshots of Catalysis in the E1 Subunit of the Pyruvate Dehydrogenase Multienzyme Complex by Pei, Xue Yuan, Titman, Christopher M., Frank, René A.W., Leeper, Finian J., Luisi, Ben F.

“…The pyruvate dehydrogenase multienzyme assembly (PDH) generates acetyl coenzyme A and reducing equivalents from pyruvate in a multiple-step process that is a…”
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The Molecular Origins of Specificity in the Assembly of a Multienzyme Complex by Frank, René A.W., Pratap, J. Venkatesh, Pei, Xue Y., Perham, Richard N., Luisi, Ben F.

“…The pyruvate dehydrogenase (PDH) multienzyme complex is central to oxidative metabolism. We present the first crystal structure of a complex between pyruvate…”
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