Search Results - "Frank, Markus H."

Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth by Kleffel, Sonja, Posch, Christian, Barthel, Steven R., Mueller, Hansgeorg, Schlapbach, Christoph, Guenova, Emmanuella, Elco, Christopher P., Lee, Nayoung, Juneja, Vikram R., Zhan, Qian, Lian, Christine G., Thomi, Rahel, Hoetzenecker, Wolfram, Cozzio, Antonio, Dummer, Reinhard, Mihm, Martin C., Flaherty, Keith T., Frank, Markus H., Murphy, George F., Sharpe, Arlene H., Kupper, Thomas S., Schatton, Tobias

“…Therapeutic antibodies targeting programmed cell death 1 (PD-1) activate tumor-specific immunity and have shown remarkable efficacy in the treatment of…”
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The therapeutic promise of the cancer stem cell concept by Frank, Natasha Y, Schatton, Tobias, Frank, Markus H

“…Cancer stem cells (CSCs) are a subpopulation of tumor cells that selectively possess tumor initiation and self-renewal capacity and the ability to give rise to…”
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Antitumor Immunity and Cancer Stem Cells by Schatton, Tobias, Frank, Markus H.

“…Self‐renewing cancer stem cells (CSC) capable of spawning more differentiated tumor cell progeny are required for tumorigenesis and neoplastic progression of…”
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Cancer stem cells and human malignant melanoma by Schatton, Tobias, Frank, Markus H

“…Summary Cancer stem cells (CSC) have been identified in hematological malignancies and several solid cancers. Similar to physiological stem cells, CSC are…”
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Suppression of Neutrophil‐Mediated Tissue Damage—A Novel Skill of Mesenchymal Stem Cells by Jiang, Dongsheng, Muschhammer, Jana, Qi, Yu, Kügler, Andrea, de Vries, Juliane C., Saffarzadeh, Mona, Sindrilaru, Anca, Beken, Seppe Vander, Wlaschek, Meinhard, Kluth, Mark A., Ganss, Christoph, Frank, Natasha Y., Frank, Markus H., Preissner, Klaus T., Scharffetter‐Kochanek, Karin

“…Mesenchymal stem cells (MSCs) are crucial for tissue homeostasis and regeneration. Though of prime interest, their potentially protective role on…”
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Skin-Derived ABCB5 + Mesenchymal Stem Cells for High-Medical-Need Inflammatory Diseases: From Discovery to Entering Clinical Routine by Niebergall-Roth, Elke, Frank, Natasha Y, Ganss, Christoph, Frank, Markus H, Kluth, Mark A

“…The ATP-binding cassette superfamily member ABCB5 identifies a subset of skin-resident mesenchymal stem cells (MSCs) that exhibit potent immunomodulatory and…”
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Identification of cells initiating human melanomas by Frank, Markus H, Schatton, Tobias, Murphy, George F, Frank, Natasha Y, Yamaura, Kazuhiro, Waaga-Gasser, Ana Maria, Gasser, Martin, Zhan, Qian, Jordan, Stefan, Duncan, Lyn M, Weishaupt, Carsten, Fuhlbrigge, Robert C, Kupper, Thomas S, Sayegh, Mohamed H

“…Tumour-initiating cells capable of self-renewal and differentiation, which are responsible for tumour growth, have been identified in human haematological…”
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Identification and targeting of cancer stem cells by Schatton, Tobias, Frank, Natasha Y, Frank, Markus H

“…Cancer stem cells (CSC) represent malignant cell subsets in hierarchically organized tumors, which are selectively capable of tumor initiation and self-renewal…”
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ABCB5 Maintains Melanoma-Initiating Cells through a Proinflammatory Cytokine Signaling Circuit by WILSON, Brian J, SAAB, Karim R, FRANK, Markus H, JIE MA, SCHATTON, Tobias, PÜTZ, Pablo, QIAN ZHAN, MURPHY, George F, GASSER, Martin, WAAGA-GASSER, Ana Maria, FRANK, Natasha Y

“…The drug efflux transporter ABCB5 identifies cancer stem-like cells (CSC) in diverse human malignancies, where its expression is associated with clinical…”
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Repairing the corneal epithelium using limbal stem cells or alternative cell-based therapies by Sasamoto, Yuzuru, Ksander, Bruce R, Frank, Markus H, Frank, Natasha Y

“…The corneal epithelium is maintained by limbal stem cells (LSCs) that reside in the basal epithelial layer of the tissue surrounding the cornea termed the…”
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Anti-Inflammatory and Anti-(Lymph)angiogenic Properties of an ABCB5+ Limbal Mesenchymal Stem Cell Population by Meshko, Berbang, Volatier, Thomas L A, Mann, Johanna, Kluth, Mark A, Ganss, Christoph, Frank, Markus H, Frank, Natasha Y, Ksander, Bruce R, Cursiefen, Claus, Notara, Maria

“…Corneal transparency and avascularity are essential for vision. The avascular cornea transitions into the vascularized conjunctiva at the limbus. Here, we…”
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Epigenetic Regulation of Corneal Epithelial Differentiation by TET2 by Sasamoto, Yuzuru, Wu, Siyuan, Lee, Catherine A A, Jiang, Jason Y, Ksander, Bruce R, Frank, Markus H, Frank, Natasha Y

“…Epigenetic DNA modification by 5-hydroxymethylcytosine (5hmC), generated by the Ten-eleven translocation (TET) dioxygenases, regulates diverse biological…”
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ABCB5+ mesenchymal stromal cells therapy protects from hypoxia by restoring Ca2+ homeostasis in vitro and in vivo by Yan, Kaixuan, Zheng, Jiaxing, Kluth, Mark Andreas, Li, Lin, Ganss, Christoph, Yard, Benito, Magdeburg, Richard, Frank, Markus H, Pallavi, Prama, Keese, Michael

“…Abstract Background Hypoxia in ischemic disease impairs Ca 2+ homeostasis and may promote angiogenesis. The therapeutic efficacy of mesenchymal stromal cells…”
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Clinical-grade human skin-derived ABCB5+ mesenchymal stromal cells exert anti-apoptotic and anti-inflammatory effects in vitro and modulate mRNA expression in a cisplatin-induced kidney injury murine model by Rendra, Erika, Crigna, Adriana Torres, Daniele, Cristina, Sticht, Carsten, Cueppers, Maike, Kluth, Mark Andreas, Ganss, Christoph, Frank, Markus H, Gretz, Norbert, Bieback, Karen

“…Acute kidney injury (AKI) is characterized by a rapid reduction in renal function and glomerular filtration rate (GFR). The broadly used anti-cancer…”
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ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma by FRANK, Natasha Y, MARGARYAN, Armen, YING HUANG, SCHATTON, Tobias, WAAGA-GASSER, Ana Maria, GASSER, Martin, SAYEGH, Mohamed H, SADEE, Wolfgang, FRANK, Markus H

“…Enhanced drug efflux mediated by ABCB1 P-glycoprotein and related ATP-binding cassette transporters is one of several mechanisms of multidrug resistance…”
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VEGFR-1 Expressed by Malignant Melanoma- Initiating Cells Is Required for Tumor Growth by FRANK, Natasha Y, SCHATTON, Tobias, WAAGA-GASSER, Ana-Maria, KUPPER, Thomas S, MURPHY, George F, FRANK, Markus H, KIM, Soo, QIAN ZHAN, WILSON, Brian J, JIE MA, SAAB, Karim R, OSHEROV, Veronika, WIDLUND, Hans R, GASSER, Martin

“…Melanoma growth is driven by malignant melanoma-initiating cells (MMIC) identified by expression of the ATP-binding cassette (ABC) member ABCB5. ABCB5(+)…”
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Expression of Cell-Surface Marker ABCB5 Causes Characteristic Modifications of Glucose, Amino Acid and Phospholipid Metabolism in the G3361 Melanoma-Initiating Cell Line by Lutz, Norbert W, Banerjee, Pallavi, Wilson, Brian J, Ma, Jie, Cozzone, Patrick J, Frank, Markus H

“…We present a pilot study aimed at determining the effects of expression of ATP-binding cassette member B5 (ABCB5), a previously described marker for…”
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ABCB5 Identifies a Therapy-Refractory Tumor Cell Population in Colorectal Cancer Patients by WILSON, Brian J, SCHATTON, Tobias, MURPHY, George F, FRANK, Markus H, FRANK, Natasha Y, QIAN ZHAN, GASSER, Martin, JIE MA, SAAB, Karim R, SCHANCHE, Robin, WAAGA-GASSER, Ana-Maria, GOLD, Jason S, QIN HUANG

“…Identification and reversal of treatment resistance mechanisms of clinically refractory tumor cells is critical for successful cancer therapy. Here we show…”
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ABCB5 Identifies Immunoregulatory Dermal Cells by Schatton, Tobias, Yang, Jun, Kleffel, Sonja, Uehara, Mayuko, Barthel, Steven R., Schlapbach, Christoph, Zhan, Qian, Dudeney, Stephen, Mueller, Hansgeorg, Lee, Nayoung, de Vries, Juliane C., Meier, Barbara, Vander Beken, Seppe, Kluth, Mark A., Ganss, Christoph, Sharpe, Arlene H., Waaga-Gasser, Ana Maria, Sayegh, Mohamed H., Abdi, Reza, Scharffetter-Kochanek, Karin, Murphy, George F., Kupper, Thomas S., Frank, Natasha Y., Frank, Markus H.

“…Cell-based strategies represent a new frontier in the treatment of immune-mediated disorders. However, the paucity of markers for isolation of molecularly…”
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Process data of allogeneic ex vivo-expanded ABCB5 + mesenchymal stromal cells for human use: off-the-shelf GMP-manufactured donor-independent ATMP by Ballikaya, Seda, Sadeghi, Samar, Niebergall-Roth, Elke, Nimtz, Laura, Frindert, Jens, Norrick, Alexandra, Stemler, Nicole, Bauer, Nicole, Rosche, Yvonne, Kratzenberg, Vanessa, Pieper, Julia, Ficek, Tina, Frank, Markus H, Ganss, Christoph, Esterlechner, Jasmina, Kluth, Mark A

“…Human dermal mesenchymal stromal cells (MSCs) expressing the ATP-binding cassette (ABC) efflux transporter ABCB5 represent an easily accessible MSC population…”
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