Search Results - "Frank, Daria"

GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1 by Vadnais, Charles, Chen, Riyan, Fraszczak, Jennifer, Yu, Zhenbao, Boulais, Jonathan, Pinder, Jordan, Frank, Daria, Khandanpour, Cyrus, Hébert, Josée, Dellaire, Graham, Côté, Jean-François, Richard, Stéphane, Orthwein, Alexandre, Drobetsky, Elliot, Möröy, Tarik

“…GFI1 is a transcriptional regulator expressed in lymphoid cells, and an “oncorequisite” factor required for development and maintenance of T-lymphoid leukemia…”
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The influence of buoyancy upon pollution trapping and dispersal in the wake of a backward-facing step by Charlwood, Samuel, Frank, Daria, Davies Wykes, Megan

“…The importance of buoyancy relative to free-stream flow is described using an adapted Froude number $Fr' = U/f_0^{1/3}$ , where $U$ is the flow speed and $f_0$…”
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Curcumin as an Epigenetic Therapeutic Agent in Myelodysplastic Syndromes (MDS) by Xie, Xiaoqing, Frank, Daria, Patnana, Pradeep Kumar, Schütte, Judith, Al-Matary, Yahya, Liu, Longlong, Wei, Lanying, Dugas, Martin, Varghese, Julian, Nimmagadda, Subbaiah Chary, Khandanpour, Cyrus

“…Growth Factor Independence 1 (GFI1) is a transcription factor with an important role in the regulation of development of myeloid and lymphoid cell lineages and…”
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Inhibiting PI3K–AKT–mTOR Signaling in Multiple Myeloma-Associated Mesenchymal Stem Cells Impedes the Proliferation of Multiple Myeloma Cells by Heinemann, Luca, Möllers, Klara Maria, Ahmed, Helal Mohammed Mohammed, Wei, Lanying, Sun, Kaiyan, Nimmagadda, Subbaiah Chary, Frank, Daria, Baumann, Anja, Poos, Alexandra M., Dugas, Martin, Varghese, Julian, Raab, Marc-Steffen, Khandanpour, Cyrus

“…The microenvironment of cancer cells is receiving increasing attention as an important factor influencing the progression and prognosis of tumor diseases. In…”
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Gfi1b: a key player in the genesis and maintenance of acute myeloid leukemia and myelodysplastic syndrome by Thivakaran, Aniththa, Botezatu, Lacramioara, Hönes, Judith M, Schütte, Judith, Vassen, Lothar, Al-Matary, Yahya S, Patnana, Pradeep, Zeller, Amos, Heuser, Michael, Thol, Felicitas, Gabdoulline, Razif, Olberding, Nadine, Frank, Daria, Suslo, Marina, Köster, Renata, Lennartz, Klaus, Görgens, Andre, Giebel, Bernd, Opalka, Bertram, Dührsen, Ulrich, Khandanpour, Cyrus

“…Differentiation of hematopoietic stem cells is regulated by a concert of different transcription factors. Disturbed transcription factor function can be the…”
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Presence of the GFI1-36N single nucleotide polymorphism enhances the response of MLL-AF9 leukemic cells to CDK4/6 inhibition by Vorwerk, Jan, Sun, Kaiyan, Frank, Daria, Neumann, Felix, Hüve, Jana, Budde, Paulina Marie, Liu, Longlong, Xie, Xiaoqing, Patnana, Pradeep Kumar, Ahmed, Helal Mohammed Mohammed, Opalka, Bertram, Lenz, Georg, Jayavelu, Ashok Kumar, Khandanpour, Cyrus

“…The zinc finger protein Growth Factor Independence 1 (GFI1) acts as a transcriptional repressor regulating differentiation of myeloid and lymphoid cells. A…”
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Dose-dependent effect of GFI1 expression in the reconstitution and the differentiation capacity of HSCs by Xie, Xiaoqing, Patnana, Pradeep Kumar, Frank, Daria, Schütte, Judith, Al-Matary, Yahya, Künstner, Axel, Busch, Hauke, Ahmed, Helal, Liu, Longlong, Engel, Daniel R, Dührsen, Ulrich, Rosenbauer, Frank, Von Bubnoff, Nikolas, Lenz, Georg, Khandanpour, Cyrus

“…GFI1 is a transcriptional repressor and plays a pivotal role in regulating the differentiation of hematopoietic stem cells (HSCs) towards myeloid and lymphoid…”
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3088 – GFI1B DEPLETION INDUCES OXIDATIVE PHOSPHORYLATION AND SENSITIZES TO METFORMIN IN MICE PRIMARY CELLS by liu, Longlong, Patnana, Pradeep Kumar, Xie, Xiaoqing, Frank, Daria, Khandanpour, Cyrus

“…Growth factor independence 1b (GFI1b) is a transcriptional repressor, regulates dormancy and proliferation of hematopoietic stem cells (HSCs). Low expression…”
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3143 – GFI1 EXPRESSION AND ITS ROLE IN THE RECONSTITUTION CAPACITY OF HSCS by Xie, Xiaoqing, Patnana, Pradeep Kumar, Frank, Daria, Schütte, Judith, Liu, Longlong, Al-Matary, Yahya Saleh, Khandanpour, Cyrus

“…Growth factor independent (GFI1) is a transcriptional repressor with a role in the maintenance of hematopoietic stem cells (HSC) and their differentiation…”
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Leukaemia Cells Induced Metabolic Alterations in AML Associated Mesenchymal Stem Cells Via Notch Signalling by Noman, Helal Mohammed Mohammed Ahmed, Al-Matary, Yahya Saleh, Nimmagadda, Subbaiah Chary, Patnana, Pradeep Kumar, Liu, Longlong, Wei, Lanying, Frank, Daria, Lenz, Georg, Khandanpour, Cyrus

“…Introduction: Acute myeloid leukaemia (AML) is a haematological malignancy with a high relapse rate and poor prognosis. Leukaemia cell proliferation is…”
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GFI1B acts as a metabolic regulator in hematopoiesis and acute myeloid leukemia by Liu, Longlong, Patnana, Pradeep Kumar, Xie, Xiaoqing, Frank, Daria, Nimmagadda, Subbaiah Chary, Su, Minhua, Zhang, Donghua, Koenig, Thorsten, Rosenbauer, Frank, Liebmann, Marie, Klotz, Luisa, Xu, Wendan, Vorwerk, Jan, Neumann, Felix, Hüve, Jana, Unger, Andreas, Okun, Jürgen Günther, Opalka, Bertram, Khandanpour, Cyrus

“…Recent studies highlighted the role of transcription factors in metabolic regulation during hematopoiesis and leukemia development. GFI1B is a transcriptional…”
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High Metabolic Dependence on Oxidative Phosphorylation Drives Sensitivity to Metformin Treatment in MLL/AF9 Acute Myeloid Leukemia by Liu, Longlong, Patnana, Pradeep Kumar, Xie, Xiaoqing, Frank, Daria, Nimmagadda, Subbaiah Chary, Rosemann, Annegret, Liebmann, Marie, Klotz, Luisa, Opalka, Bertram, Khandanpour, Cyrus

“…Acute myeloid leukemia (AML) is a group of hematological cancers with metabolic heterogeneity. Oxidative phosphorylation (OXPHOS) has been reported to play an…”
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3112 – GROWTH FACTOR INDEPENDENCE 1 EXPRESSION INDUCED METABOLIC VULNERABILITIES AND PRESENTS NOVEL THERAPEUTIC OPPORTUNITIES IN ACUTE MYELOID LEUKAEMIA by Patnana, Pradeep Kumar, Behrens, Matthias, Klotz, Luisa, Liebmann, Marie, Frank, Daria, Nimmagadda, Chary, Siveke, Jens, Trajkovic-Arsic, Marija, Thivakaran, Aniththa, Hanenberg, Helmut, Lenz, Georg, Khandanpour, Cyrus

“…Growth Factor Independence 1 (GFI1) is a hematopoietic transcriptional repressor and plays an essential role in self-renewal and differentiation of healthy…”
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Targeting PI3K-AKT-mTOR Signaling in Multiple Myeloma Mesenchymal Stem Cells Mediates Antiproliferative Effect on Myeloma Cells by Heinmann, Luca, Noman, Helal Mohammed Mohammed Ahmed, Möllers, Klara, Nimmagadda, Subbaiah Chary, Sun, Kaiyan, Frank, Daria, Korab, Hanna, Wei, Lanying, Baumann, Anja, Poos, Alexandra, Raab, Marc-Steffen, Lenz, Georg, Khandanpour, Cyrus

“…Introduction: Multiple myeloma (MM) is a B-cell malignancy characterized by an abnormal proliferation and infiltration of malignant plasma cells in the bone…”
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A synthetic covalent ligand of the C/EBPβ transactivation domain inhibits acute myeloid leukemia cells by Abdel Ghani, Luca, Yusenko, Maria V., Frank, Daria, Moorthy, Ramkumar, Widen, John C., Dörner, Wolfgang, Khandanpour, Cyrus, Harki, Daniel A., Klempnauer, Karl-Heinz

“…C/EBPβ has recently emerged as a pro-leukemogenic transcription factor that cooperates with oncoprotein MYB to maintain proliferation and differentiation block…”
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Dexamethasone‐mediated inhibition of Notch signalling blocks the interaction of leukaemia and mesenchymal stromal cells by Ahmed, Helal Mohammed Mohammed, Nimmagadda, Subbaiah Chary, Al‐Matary, Yahya S., Fiori, Maren, May, Tobias, Frank, Daria, Patnana, Pradeep Kumar, Récher, Christian, Schliemann, Christoph, Mikesch, Jan‐Henrik, Koenig, Thorsten, Rosenbauer, Frank, Hartmann, Wolfgang, Tuckermann, Jan, Dührsen, Ulrich, Lanying, Wei, Dugas, Martin, Opalka, Bertram, Lenz, Georg, Khandanpour, Cyrus

“…Summary Acute myeloid leukaemia (AML) is a haematological malignancy characterized by a poor prognosis. Bone marrow mesenchymal stromal cells (BM MSCs) support…”
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Dose‐dependent expression of GFI1 alters metabolism in the haematopoietic progenitors and MLL::AF9‐induced leukaemic cells by Patnana, Pradeep Kumar, Liu, Longlong, Frank, Daria, Nimmagadda, Subbaiah Chary, Behrens, Matthias, Ahmed, Helal, Xie, Xiaoqing, Liebmann, Marie, Wei, Lanying, Gerdemann, Andrea, Thivakaran, Aniththa, Humpf, Hans‐Ulrich, Klotz, Luisa, Dugas, Martin, Varghese, Julian, Trajkovic‐Arsic, Marija, Siveke, Jens T., Hanenberg, Helmut, Opalka, Bertram, Dührsen, Ulrich, Reinhardt, Hans Christian, Guenther, Ulrich, Bubnoff, Nikolas, Khandanpour, Cyrus

“…Summary Growth factor independence 1 (GFI1) is a transcriptional repressor protein that plays an essential role in the differentiation of myeloid and lymphoid…”
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CURCUMIN AS A NOVEL EPIGENETIC TREATMENT APPROACH FOR GFI1-ASSOCIATED MDS/AML by Schütte, Judith, Thivakaran, Aniththa, Heinrichs, Dennis, Al-Matary, Yahya, Vaßen, Lothar, Patnana, Pradeep, Frank, Daria, Suslo, Marina, Dührsen, Ulrich, Khandanpour, Cyrus

“…Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are diseases caused by an ineffective myelopoiesis. AML is an aggressive blood cancer with poor…”
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AML Associated Mesenchymal Stroma Cells Support Growth of AML Cells As a Result of Activated Notch Signaling and This Can be Targeted By Dexamethasone by Ahmed, Helal Mohammed Mohammed Ahmed, Al-Matary, Yahya Saleh, Nimmagadda, Subbaiah Chary, Fiori, Maren, Patnana, Pradeep Kumar, Frank, Daria, Wei, Lanying, Schütte, Judith, May, Tobias, Goethert, Joachim R., Schroeder, Thomas, Buttkereit, Ulrike, Recher, Christian, Rodríguez-Paredes, Manuel, Koenig, Thorsten, Hartmann, Wolfgang, Tuckermann, Jan, Opalka, Bertram, Lenz, Georg, Khandanpour, Cyrus

“…Introduction: Acute myeloid leukemia (AML) is a hematological malignancy characterized by poor prognosis. Interaction with bone marrow mesenchymal stromal…”
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Bcr-TMP, a Novel Nanomolar-Active Compound That Exhibits Both MYB- and Microtubule-Inhibitory Activity by Yusenko, Maria V, Biyanee, Abhiruchi, Frank, Daria, Köhler, Leonhard H F, Andersson, Mattias K, Khandanpour, Cyrus, Schobert, Rainer, Stenman, Göran, Biersack, Bernhard, Klempnauer, Karl-Heinz

“…Studies of the role of MYB in human malignancies have highlighted MYB as a potential drug target for acute myeloid leukemia (AML) and adenoid cystic carcinoma…”
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