Search Results - "Francy, Christopher A"

Cardiolipin's propensity for phase transition and its reorganization by dynamin-related protein 1 form a basis for mitochondrial membrane fission by Stepanyants, Natalia, Macdonald, Patrick J, Francy, Christopher A, Mears, Jason A, Qi, Xin, Ramachandran, Rajesh

“…Cardiolipin (CL) is an atypical, dimeric phospholipid essential for mitochondrial dynamics in eukaryotic cells. Dynamin-related protein 1 (Drp1), a cytosolic…”
Get full text

The Mechanoenzymatic Core of Dynamin-related Protein 1 Comprises the Minimal Machinery Required for Membrane Constriction by Francy, Christopher A., Alvarez, Frances J.D., Zhou, Louie, Ramachandran, Rajesh, Mears, Jason A.

“…Mitochondria are dynamic organelles that continually undergo cycles of fission and fusion. Dynamin-related protein 1 (Drp1), a large GTPase of the dynamin…”
Get full text

Distinct Splice Variants of Dynamin-related Protein 1 Differentially Utilize Mitochondrial Fission Factor as an Effector of Cooperative GTPase Activity by Macdonald, Patrick J., Francy, Christopher A., Stepanyants, Natalia, Lehman, Lance, Baglio, Anthony, Mears, Jason A., Qi, Xin, Ramachandran, Rajesh

“…Multiple isoforms of the mitochondrial fission GTPase dynamin-related protein 1 (Drp1) arise from the alternative splicing of its single gene-encoded pre-mRNA…”
Get full text

Cryo-EM Studies of Drp1 Reveal Cardiolipin Interactions that Activate the Helical Oligomer by Francy, Christopher A., Clinton, Ryan W., Fröhlich, Chris, Murphy, Colleen, Mears, Jason A.

“…Dynamins are mechano-chemical GTPases involved in the remodeling of cellular membranes. In this study, we have investigated the mechanism of dynamin-related…”
Get full text

Dynamin-related Protein 1 Oligomerization in Solution Impairs Functional Interactions with Membrane-anchored Mitochondrial Fission Factor by Clinton, Ryan W., Francy, Christopher A., Ramachandran, Rajesh, Qi, Xin, Mears, Jason A.

“…Mitochondrial fission is a crucial cellular process mediated by the mechanoenzymatic GTPase, dynamin-related protein 1 (Drp1). During mitochondrial division,…”
Get full text

Defining Membrane Interactions that Drive Dynamin Related Protein 1 (Drp1) Oligomerization using cryo-EM by Francy, Christopher A., Frohlich, Chris, Daumke, Oliver, Mears, Jason A.

Get full text

Structural Studies that Define Regulatory Interactions Within the Mitochondrial Fission Machinery by Mears, Jason A., Francy, Christopher A., Clinton, Ryan W., Lee, Serena

Get full text

Examining Drp1 Conformational Changes and Domain Interactions in the Mitochondrial Fission Complex using Cryo-Em by Francy, Christopher A., Frölich, Chris, Daumke, Oliver, Mears, Jason A.

Get full text

Cryo-Em Studies of DRP1 Self-Assembly Provide Insights into the Mechanism of Mitochondrial Fission by Alvarez, Frances J.D., Francy, Christopher A., Mears, Jason A.

Get full text

The Mechanoenzymatic Properties of Drp1 in Nucleotide Induced Constriction of Lipid Bilayers by Francy, Christopher A., Alvarez, Frances J.D., Zhou, Louie, Mears, Jason A.

Get full text

Investigating the Functional Role of Drp1 in Mitochondrial Fission by Francy, Christopher A

“…Mitochondria are dynamic organelles that continually undergo cycles of fission and fusion. Maintaining this fission/fusion balance is extremely important in…”
Get full text