Search Results - "Francois, Nathan"

Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation by Burgener, Sabrina Sofia, Leborgne, Nathan Georges François, Snipas, Scott J., Salvesen, Guy S., Bird, Phillip Ian, Benarafa, Charaf

“…Neutrophil granule serine proteases contribute to immune responses through cleavage of microbial toxins and structural proteins. They induce tissue damage and…”
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Luteolin Isolated from Juncus acutus L., a Potential Remedy for Human Coronavirus 229E by Hakem, Asma, Desmarets, Lowiese, Sahli, Ramla, Malek, Rawen Ben, Camuzet, Charline, François, Nathan, Lefèvre, Gabriel, Samaillie, Jennifer, Moureu, Sophie, Sahpaz, Sevser, Belouzard, Sandrine, Ksouri, Riadh, Séron, Karin, Rivière, Céline

“…The COVID-19 pandemic, caused by SARS-CoV-2, addressed the lack of specific antiviral drugs against coronaviruses. In this study, bioguided fractionation…”
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New Phenolic Lipids from the Leaves of Clausena harmandiana Inhibit SARS-CoV-2 Entry into Host Cells by Chambon, Marion, Herrscher, Charline, Al Halabi, Dana, François, Nathan, Belouzard, Sandrine, Boutet, Stéphanie, Pham, Van Cuong, Doan, Thi Mai Huong, Séron, Karin, Mavingui, Patrick, Litaudon, Marc, El Kalamouni, Chaker, Apel, Cécile

“…Induced by the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the COVID-19 pandemic underlined the clear need for antivirals against…”
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Lichen or Associated Micro-Organism Compounds Are Active against Human Coronaviruses by Desmarets, Lowiese, Millot, Marion, Chollet-Krugler, Marylène, Boustie, Joël, Camuzet, Charline, François, Nathan, Rouillé, Yves, Belouzard, Sandrine, Tomasi, Sophie, Mambu, Lengo, Séron, Karin

“…(1) Background: Since the emergence of SARS-CoV-2, responsible for the COVID-19 pandemic, efforts have been made to identify antiviral compounds against human…”
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Hyperforin, the major metabolite of St. John's wort, exhibits pan-coronavirus antiviral activity by Raczkiewicz, Imelda, Rivière, Céline, Bouquet, Peggy, Desmarets, Lowiese, Tarricone, Audrey, Camuzet, Charline, François, Nathan, Lefèvre, Gabriel, Silva Angulo, Fabiola, Robil, Cyril, Trottein, François, Sahpaz, Sevser, Dubuisson, Jean, Belouzard, Sandrine, Goffard, Anne, Séron, Karin

“…The COVID-19 pandemic caused by the SARS-CoV-2 virus has underscored the urgent necessity for the development of antiviral compounds that can effectively…”
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Rapid Generation of Coronaviral Immunity Using Recombinant Peptide Modified Nanodiamonds by Bilyy, Rostyslav, Pagneux, Quentin, François, Nathan, Bila, Galyna, Grytsko, Roman, Lebedin, Yuri, Barras, Alexandre, Dubuisson, Jean, Belouzard, Sandrine, Séron, Karin, Boukherroub, Rabah, Szunerits, Sabine

“…Vaccination remains one of the most effective tools to prevent infectious diseases. To ensure that the best possible antigenic components are chosen to…”
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Distinct receptor binding domain IgG thresholds predict protective host immunity across SARS-CoV-2 variants and time by Kenny, Grace, O’Reilly, Sophie, Wrigley Kelly, Neil, Negi, Riya, Gaillard, Colette, Alalwan, Dana, Saini, Gurvin, Alrawahneh, Tamara, Francois, Nathan, Angeliadis, Matthew, Garcia Leon, Alejandro Abner, Tinago, Willard, Feeney, Eoin R., Cotter, Aoife G., de Barra, Eoghan, Yousif, Obada, Horgan, Mary, Doran, Peter, Stemler, Jannik, Koehler, Philipp, Cox, Rebecca Jane, O’Shea, Donal, Olesen, Ole F., Landay, Alan, Hogan, Andrew E., Lelievre, Jean-Daniel, Gautier, Virginie, Cornely, Oliver A., Mallon, Patrick W. G.

“…SARS-CoV-2 neutralising antibodies provide protection against COVID-19. Evidence from early vaccine trials suggested binding antibody thresholds could serve as…”
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Development of a novel medium throughput flow-cytometry based micro-neutralisation test for SARS-CoV-2 with applications in clinical vaccine trials and antibody screening by O'Reilly, Sophie, Kenny, Grace, Alrawahneh, Tamara, Francois, Nathan, Gu, Lili, Angeliadis, Matthew, de Masson d'Autume, Valentin, Garcia Leon, Alejandro, Feeney, Eoin R, Yousif, Obada, Cotter, Aoife, de Barra, Eoghan, Horgan, Mary, Mallon, Patrick W. G, Gautier, Virginie

“…Quantifying neutralising capacity of circulating SARS-COV-2 antibodies is critical in evaluating protective humoral immune responses generated…”
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Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells by Burgener, Sabrina Sofia, Brügger, Melanie, Leborgne, Nathan Georges François, Sollberger, Sophia, Basilico, Paola, Kaufmann, Thomas, Bird, Phillip Ian, Benarafa, Charaf

“…Mast cells are multifunctional immune cells scattered in tissues near blood vessels and mucosal surfaces where they mediate important reactions against…”
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A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic Coronaviruses by Meunier, Thomas, Desmarets, Lowiese, Bordage, Simon, Bamba, Moussa, Hervouet, Kévin, Rouillé, Yves, François, Nathan, Decossas, Marion, Sencio, Valentin, Trottein, François, Tra Bi, Fézan Honora, Lambert, Olivier, Dubuisson, Jean, Belouzard, Sandrine, Sahpaz, Sevser, Séron, Karin

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak has highlighted the need for broad-spectrum antivirals against coronaviruses (CoVs)…”
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Correction: Bilyy et al. Rapid Generation of Coronaviral Immunity Using Recombinant Peptide Modified Nanodiamonds. Pathogens 2021, 10 , 861 by Bilyy, Rostyslav, Pagneux, Quentin, François, Nathan, Bila, Galyna, Grytsko, Roman, Lebedin, Yuri, Barras, Alexandre, Dubuisson, Jean, Belouzard, Sandrine, Séron, Karin, Boukherroub, Rabah, Szunerits, Sabine

“…In the original publication [...]…”
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1057. Development of a Flow Cytometry-Based Micro-Neutralisation Assay to Evaluate Humoral Immunity Against SARS-CoV-2 Variants of Concern in Vaccine Trials by O’Reilly, Sophie R, Kenny, Grace, Alrawahneh, Tamara, Francois, Nathan, Angeliadis, Matthew, de Masson d’Autume, Valentin, Garcia-Leon, Alejandro, Feeney, Eoin, Yousif, Obada, Cotter, Aoife, de Barra, Eoghan, Horgan, Mary, Mallon, Patrick, BCh, M B, Gautier, Virginie

“…Abstract Background Quantifying neutralising capacity of circulating SARS-COV-2 antibodies is critical in evaluating protective humoral immune responses…”
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2356. Close correlation of RBD with Live Viral Neutralising Capacity Across Variants and Time Supports Use of RBD Thresholds to Predict Protective Host Immunity by Kenny, Grace, O’Reilly, Sophie R, Kelly, Neil Wrigley, Negi, Riya, Gaillard, Colette Marie, Alalwan, Dana, Saini, Gurvin, Alrawahneh, Tamara, Francois, Nathan, Angeliadis, Matthew, García-León, Alejandro, Tinago, Willard, Feeney, Eoin R, Cotter, Aoife, de Barra, Eoghan, Yousif, Obada, Horgan, Mary, Doran, Peter, Cox, Rebecca J, O’Shea, Donal, Olesen, Ole, Landay, Alan, Hogan, Andrew, Lelièvre, Jean-Daniel, Gautier, Virginie, Cornely, Oliver A, Mallon, Patrick

“…Abstract Background Although SARS-CoV-2 neutralising antibodies protect against severe COVID-19, whether circulating IgG titres reflect underlying host…”
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Development of a novel medium throughput flow-cytometry based micro-neutralisation test for SARS-CoV-2 with applications in clinical vaccine trials and antibody screening by Sophie O'Reilly, Grace Kenny, Tamara Alrawahneh, Nathan Francois, Lili Gu, Matthew Angeliadis, Valentin de Masson d'Autume, Alejandro Garcia Leon, Eoin R Feeney, Obada Yousif, Aoife Cotter, Eoghan de Barra, Mary Horgan, Patrick W G Mallon, Virginie Gautier

“…Quantifying neutralising capacity of circulating SARS-COV-2 antibodies is critical in evaluating protective humoral immune responses generated…”
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The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype by Barut, G. Tuba, Halwe, Nico Joel, Taddeo, Adriano, Kelly, Jenna N., Schön, Jacob, Ebert, Nadine, Ulrich, Lorenz, Devisme, Christelle, Steiner, Silvio, Trüeb, Bettina Salome, Hoffmann, Bernd, Veiga, Inês Berenguer, Leborgne, Nathan Georges François, Moreira, Etori Aguiar, Breithaupt, Angele, Wylezich, Claudia, Höper, Dirk, Wernike, Kerstin, Godel, Aurélie, Thomann, Lisa, Flück, Vera, Stalder, Hanspeter, Brügger, Melanie, Esteves, Blandina I. Oliveira, Zumkehr, Beatrice, Beilleau, Guillaume, Kratzel, Annika, Schmied, Kimberly, Ochsenbein, Sarah, Lang, Reto M., Wider, Manon, Machahua, Carlos, Dorn, Patrick, Marti, Thomas M., Funke-Chambour, Manuela, Rauch, Andri, Widera, Marek, Ciesek, Sandra, Dijkman, Ronald, Hoffmann, Donata, Alves, Marco P., Benarafa, Charaf, Beer, Martin, Thiel, Volker

“…Variant of concern (VOC) Omicron-BA.1 has achieved global predominance in early 2022. Therefore, surveillance and comprehensive characterization of…”
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New Phenolic Lipids from the Leaves of IClausena harmandiana/I Inhibit SARS-CoV-2 Entry into Host Cells by Chambon, Marion, Herrscher, Charline, Al Halabi, Dana, François, Nathan, Belouzard, Sandrine, Boutet, Stéphanie, Pham, Van Cuong, Doan, Thi Mai Huong, Séron, Karin, Mavingui, Patrick, Litaudon, Marc, El Kalamouni, Chaker, Apel, Cécile

“…Induced by the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the COVID-19 pandemic underlined the clear need for antivirals against…”
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Luteolin Isolated from IJuncus acutus/I L., a Potential Remedy for Human Coronavirus 229E by Hakem, Asma, Desmarets, Lowiese, Sahli, Ramla, Malek, Rawen Ben, Camuzet, Charline, François, Nathan, Lefèvre, Gabriel, Samaillie, Jennifer, Moureu, Sophie, Sahpaz, Sevser, Belouzard, Sandrine, Ksouri, Riadh, Séron, Karin, Rivière, Céline

“…The COVID-19 pandemic, caused by SARS-CoV-2, addressed the lack of specific antiviral drugs against coronaviruses. In this study, bioguided fractionation…”
Get full text

Correction: Bilyy et al. Rapid Generation of Coronaviral Immunity Using Recombinant Peptide Modified Nanodiamonds. IPathogens/I 2021, I10/I, 861 by Bilyy, Rostyslav, Pagneux, Quentin, François, Nathan, Bila, Galyna, Grytsko, Roman, Lebedin, Yuri, Barras, Alexandre, Dubuisson, Jean, Belouzard, Sandrine, Séron, Karin, Boukherroub, Rabah, Szunerits, Sabine

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Cathepsin G inhibition by Serpinb1 and Serpinb6 prevent programmed necrosis in neutrophils and monocytes and reduce GSDMD-driven inflammation by Burgener, Sabrina Sofia, Leborgne, Nathan Georges François, Snipas, Scott J., Salvesen, Guy S., Bird, Phillip Ian, Benarafa, Charaf

“…Neutrophil granule serine proteases contribute to immune responses through cleavage of microbial toxins and structural proteins. They induce tissue damage and…”
Get full text