Search Results - "Franco‐Penteado, Carla Fernanda"
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Red blood cells microparticles are associated with hemolysis markers and may contribute to clinical events among sickle cell disease patients
Published in Annals of hematology (01-11-2019)“…Microparticles are sub-micron vesicles possessing protein and other materials derived from the plasma membrane of their parent cells, and literature suggests…”
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A novel experimental model of erectile dysfunction in rats with heart failure using volume overload
Published in PloS one (02-11-2017)“…Patients with heart failure (HF) display erectile dysfunction (ED). However, the pathophysiology of ED during HF remains poorly investigated. This study aimed…”
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3
Hydroxycarbamide reduces eosinophil adhesion and degranulation in sickle cell anaemia patients
Published in British journal of haematology (01-01-2014)“…Summary Inflammation, leucocyte and red cell adhesion to the endothelium contribute to the pathogenesis of sickle cell anaemia. Neutrophils appear to be…”
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Urinary Bladder Dysfunction in Transgenic Sickle Cell Disease Mice
Published in PloS one (04-08-2015)“…Urological complications associated with sickle cell disease (SCD), include nocturia, enuresis, urinary infections and urinary incontinence. However,…”
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Erythropoiesis‐driven regulation of hepcidin in human red cell disorders is better reflected through concentrations of soluble transferrin receptor rather than growth differentiation factor 15
Published in American journal of hematology (01-04-2014)“…Growth differentiation factor 15 (GDF‐15) is a bone marrow‐derived cytokine whose ability to suppress iron regulator hepcidin in vitro and increased…”
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Increased Cavernosal Relaxations in Sickle Cell Mice Priapism are Associated with Alterations in the NO-cGMP Signaling Pathway
Published in Journal of sexual medicine (01-08-2009)“…Priapism is defined as prolonged and persistent penile erection, unassociated with sexual interest or stimulation, and is one of the many serious complications…”
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Effect of PDE9 inhibitor BAY 73‐6691 in the contractile response of cavernosal and detrusor smooth muscle of sickle cell disease mice
Published in The FASEB journal (01-04-2019)“…Introduction Genitourinary tract function is affected in sickle cell disease (SCD). Modulation of cyclic guanosine monophosphate (cGMP)‐dependent signalling is…”
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Fasudil, a ROCK inhibitor, attenuates endotelial‐leukocyte interaction in sickle cell transgenic mice
Published in The FASEB journal (01-04-2018)“…Introduction Sickle cell disease (SCD) is one of the most common genetic disorder worldwide, caused by point mutations in the gene encoding the hemoglobin β…”
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Rock Inhibitor Fasudil Reduces Leukocyte-Endothelium Interactions in the Microvasculature of a Sickle Cell Mouse Model of Allergic Inflammation
Published in Blood (08-12-2017)“…Introduction: Sickle cell disease (SCD) vaso-occlusion process involves different cell types, such as red blood cells,activated endothelial cells, platelets…”
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miRNA-146a, miRNA-203a, and miRNA-223 Modulate Inflammatory Response in LPS- Acute Lung Injury in Sickle Cell Transgenic Mice
Published in Blood (03-12-2015)“…Introduction: Mouse models have allowed a wider investigation of the inflammatory process in Sickle cell disease (SCD). Previous studies have demonstrated that…”
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Red Blood Cells Microparticles Are Associated with Hemolysis Markers and Leg Ulceration in Patients with Sickle Cell Disease
Published in Blood (08-12-2017)“…Microparticles are sub-micron, unilamellar vesicles possessing protein and other materials derived from the plasma membrane of their parent cells and…”
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Intravascular Hemolysis Leads to Increased Esophagus Smooth Muscle Contractions in Mice: Implication for Dysphagia and Odynophagia
Published in Blood (08-12-2017)“…Introduction: The nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway is well established as a regulatory pathway of smooth muscle…”
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Townes Transgenic Sickle Cell Mouse Model Displays Erectile Dysfunction
Published in Blood (06-12-2014)“…Introduction: Erectile function alterations result from an imbalance of nitric oxide (NO)-mediated relaxations and sympathetic-mediated vasoconstriction in the…”
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Rho-Kinase Inhibition Attenuates Airway Inflammation In An Experimental Asthma Model In Sickle Cell Mice
Published in Blood (15-11-2013)“…Asthma in sickle cell disease is known to be associated with increased morbidity and an elevated rate of sickle cell complications, such as acute chest…”
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Young and Old Sickle Cell Disease Transgenic Mice Present Underactive Bladder
Published in Blood (15-11-2013)“…Urinary bladder dysfunction is rarely spontaneously reported by sickle cell disease (SCD) patients to their caregivers. With increasing survival of these…”
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Design, Synthesis, and Pharmacological Evaluation of Novel Hybrid Compounds To Treat Sickle Cell Disease Symptoms
Published in Journal of medicinal chemistry (25-08-2011)“…A novel series of thalidomide derivatives (4a–f) designed by molecular hybridization were synthesized and evaluated in vitro and in vivo for their potential…”
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Oxidative Stress Contributes to Overactive Bladder in the Transgenic Sickle Cell Mouse
Published in Blood (03-12-2015)“…Introduction: Lower urinary tract symptoms (LUTS) such as nocturia, urinary frequency, and urgency have been clinically reported in children and adults with…”
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Increased Inflammatory Properties of Neutrophils in Patients with Venous Thromboembolism and the Effect of Simvastatin on Abrogating Inflamed Neutrophils Adhesiveness
Published in Blood (02-12-2016)“…Neutrophils have a complex migrating process out of the vascular lumen, that consists of chemoattraction and rolling, followed by firm attachment and migration…”
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High Transferrin Saturation Is Associated with Lower Monocytic Ferritin Heavy Chain Expression in Sickle Cell Anemia Patients
Published in Blood (06-12-2014)“…The pathophysiology of sickle cell anemia (SCA) involves hemolysis, vaso-occlusion and a chronic inflammatory state. Iron overload secondary to blood…”
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Inhibition Of the Rho/Rho-Kinase Pathway Reduces In Vitro Adhesion Of Sickle Cell Anemia Eosinophils To Human Endothelial Cells
Published in Blood (15-11-2013)“…Sickle cell anemia (SCA) individuals present a chronic inflammatory condition that contributes to the recurrent episodes of vaso-occlusion. This process is a…”
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