Clinical characteristics and outcomes of patients hospitalized with COVID-19 in Brazil: Results from the Brazilian COVID-19 registry

To describe the clinical characteristics, laboratory results, imaging findings, and in-hospital outcomes of COVID-19 patients admitted to Brazilian hospitals. A cohort study of laboratory-confirmed COVID-19 patients who were hospitalized from March 2020 to September 2020 in 25 hospitals. Data were c...

Full description

Saved in:

Bibliographic Details
Published in:	International journal of infectious diseases Vol. 107; pp. 300 - 310
Main Authors:	Marcolino, Milena S., Ziegelmann, Patricia K., Souza-Silva, Maira V.R., Nascimento, I.J.B., Oliveira, Luana M., Monteiro, Luanna S., Sales, Thaís L.S., Ruschel, Karen B., Martins, Karina P.M.P., Etges, Ana Paula B.S., Molina, Israel, Polanczyk, Carisi A., Schwarzbold, Alexandre Vargas, de Oliveira Maurílio, Amanda, de Barros, Ana Lara Rodrigues Monteiro, Scotton, Ana Luiza Bahia Alves, Rodríguez-Morales, Alfonso J., dos Reis, Anderson Lacerda, Moura Costa, André Soares, de Oliveira, Argenil José Assis, Farace, Bárbara Lopes, da Silva, Carla Thais Cândida Alves, Ramos, Carolina Marques, Cimini, Christiane Corrêa Rodrigues, de Carvalho, Cíntia Alcantara, Silveira, Daniel Vitório, Ponce, Daniela, Kroger, Emanuele Marianne Souza, Manenti, Euler Roberto Fernandes, Lucas, Fernanda Barbosa, Rodrigues, Fernanda d'Athayde, Anschau, Fernando, Botoni, Fernando Antonio, Bartolazzi, Frederico, Crestani, Gabriela Petry, Nascimento, Guilherme Fagundes, Noal, Helena Carolina, Duani, Helena, Vianna, Heloisa Reniers, Guimarães, Henrique Cerqueira, de Alvarenga, Joice Coutinho, de Morais, Júlia Drumond Parreiras, Rugolo, Juliana Machado, Franco, Lara Monalyza Gonçalves, Moreira, Leila Beltrami, de Oliveira, Leonardo Seixas, Pinheiro, Lílian Santos, Pacheco, Liliane Souto, Kopittke, Luciane, de Souza Viana, Luciano, de Moura, Luis Cesar Souto, Santos, Luisa Elem Almeida, de Souza Cabral, Máderson Alvares, Souza, Maíra Dias, Tofani, Marcela Gonçalves Trindade, da Silveira, Marconi Franco, de Melo Andrade, Marcus Vinicius, Ferreira, Maria Angélica Pires, Bicalho, Maria Aparecida Camargos, Martins, Maria Auxiliadora Parreiras, Lima, Maria Clara Pontello Barbosa, Borges, Mariana Balbinot, Canesso, Mariana de Braga Lima Carvalho, Nogueira, Matheus Carvalho Alves, de Figueiredo, Meire Pereira, Guimarães Junior, Milton Henriques, Almeida, Mychelle Stefany Santos, de Sordi, Mônica Aparecida de Paula, Sampaio, Natália da Cunha Severino, de Oliveira, Neimy Ramos, Vianna, Paulo Tarso Lima, Andrade, Pedro Guido Soares, Assaf, Pedro Ledic, Oliveira, Rafael Fusaro Aguiar, de Carvalho, Rafael Lima Rodrigues, de Almeida, Rafaela dos Santos Charão, Martins, Raphael Castro, Valacio, Reginaldo Aparecido, Cardoso, Ricardo Bertoglio, Coelho, Ricardo Braga, Pozza, Roberta, Mourato, Rodolfo Lucas Silva, Vieira, Rodrigo Costa Pereira, de Abreu, Roger Mendes, Silva, Rufino de Freitas, Francisco, Saionara Cristina, Guimarães, Silvana Mangeon Mereilles, Araújo, Silvia Ferreira, Oliveira, Talita Fischer, de Vargas, Tatiana, Fereguetti, Tatiani Oliveira, Lage, Thalita Martins, Diniz, Thulio Henrique Oliveira, dos Santos, Veridiana Baldon
Format:	Journal Article
Language:	English
Published:	Canada Elsevier Ltd 01-06-2021 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases Elsevier
Subjects:	Brazil COVID-19 disease progression hospitalizations mortality pandemic SARS-CoV-2 COVID-19 SARS-CoV-2 Brazil mortality disease progression pandemic hospitalizations
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	To describe the clinical characteristics, laboratory results, imaging findings, and in-hospital outcomes of COVID-19 patients admitted to Brazilian hospitals. A cohort study of laboratory-confirmed COVID-19 patients who were hospitalized from March 2020 to September 2020 in 25 hospitals. Data were collected from medical records using Research Electronic Data Capture (REDCap) tools. A multivariate Poisson regression model was used to assess the risk factors for in-hospital mortality. For a total of 2,054 patients (52.6% male; median age of 58 years), the in-hospital mortality was 22.0%; this rose to 47.6% for those treated in the intensive care unit (ICU). Hypertension (52.9%), diabetes (29.2%), and obesity (17.2%) were the most prevalent comorbidities. Overall, 32.5% required invasive mechanical ventilation, and 12.1% required kidney replacement therapy. Septic shock was observed in 15.0%, nosocomial infection in 13.1%, thromboembolism in 4.1%, and acute heart failure in 3.6%. Age >= 65 years, chronic kidney disease, hypertension, C-reactive protein ≥ 100mg/dL, platelet count < 100×109/L, oxygen saturation < 90%, the need for supplemental oxygen, and invasive mechanical ventilation at admission were independently associated with a higher risk of in-hospital mortality. The overall use of antimicrobials was 87.9%. This study reveals the characteristics and in-hospital outcomes of hospitalized patients with confirmed COVID-19 in Brazil. Certain easily assessed parameters at hospital admission were independently associated with a higher risk of death. The high frequency of antibiotic use points to an over-use of antimicrobials in COVID-19 patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Brazilian COVID-19 Registry Investigators are listed at the end of this paper.
ISSN:	1201-9712 1878-3511
DOI:	10.1016/j.ijid.2021.01.019