Search Results - "Franco, Heather L."

FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation by Vasquez, Yasmin M, Wang, Xiaoqiu, Wetendorf, Margeaux, Franco, Heather L, Mo, Qianxing, Wang, Tianyuan, Lanz, Rainer B, Young, Steven L, Lessey, Bruce A, Spencer, Thomas E, Lydon, John P, DeMayo, Francesco J

“…Successful embryo implantation requires a receptive endometrium. Poor uterine receptivity can account for implantation failure in women who experience…”
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Elimination of the male reproductive tract in the female embryo is promoted by COUP-TFII in mice by Zhao, Fei, Franco, Heather L., Rodriguez, Karina F., Brown, Paula R., Tsai, Ming-Jer, Tsai, Sophia Y., Yao, Humphrey H.-C.

“…The sexual differentiation paradigm contends that the female pattern of the reproductive system is established by default because the male reproductive tracts…”
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A Gata2-Dependent Transcription Network Regulates Uterine Progesterone Responsiveness and Endometrial Function by Rubel, Cory A., Wu, San-Pin, Lin, Lin, Wang, Tianyuan, Lanz, Rainer B., Li, Xilong, Kommagani, Ramakrishna, Franco, Heather L., Camper, Sally A., Tong, Qiang, Jeong, Jae-Wook, Lydon, John P., DeMayo, Francesco J.

“…Altered progesterone responsiveness leads to female infertility and cancer, but underlying mechanisms remain unclear. Mice with uterine-specific ablation of…”
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WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse by Franco, Heather L., Dai, Daisy, Lee, Kevin Y., Rubel, Cory A., Roop, Dennis, Boerboom, Derek, Jeong, Jae‐Wook, Lydon, John P., Bagchi, Indrani C., Bagchi, Milan K., DeMayo, Francesco J.

“…ABSTRACT WNT4, a member of the Wnt family of ligands, is critical for the development of the female reproductive tract. Analysis of Wnt4 expression in the…”
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Research Resource: Genome-Wide Profiling of Progesterone Receptor Binding in the Mouse Uterus by Rubel, Cory A, Lanz, Rainer B, Kommagani, Ramakrishna, Franco, Heather L, Lydon, John P, DeMayo, Francesco J

“…Progesterone (P4) signaling through its nuclear transcription factor, the progesterone receptor (PR), is essential for normal uterine function. Although…”
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Deletion of Dicer in Somatic Cells of the Female Reproductive Tract Causes Sterility by Nagaraja, Ankur K, Andreu-Vieyra, Claudia, Franco, Heather L, Ma, Lang, Chen, Ruihong, Han, Derek Y, Zhu, Huifeng, Agno, Julio E, Gunaratne, Preethi H, DeMayo, Francesco J, Matzuk, Martin M

“…Dicer is an evolutionarily conserved ribonuclease III that is necessary for microRNA (miRNA) processing and the synthesis of small interfering RNAs from long…”
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Epithelial progesterone receptor exhibits pleiotropic roles in uterine development and function by Franco, Heather L., Rubel, Cory A., Large, Michael J., Wetendorf, Margeaux, Fernandez‐Valdivia, Rodrigo, Jeong, Jae‐Wook, Spencer, Thomas E., Behringer, Richard R., Lydon, John P., DeMayo, Francesco J.

“…The ovarian steroid progesterone, acting through the progesterone receptor (PR), coordinates endometrial epithelial‐stromal cell communication, which is…”
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A transcriptome-wide screen for mRNAs enriched in fetal Leydig cells: CRHR1 agonism stimulates rat and mouse fetal testis steroidogenesis by McDowell, Erin N, Kisielewski, Anne E, Pike, Jack W, Franco, Heather L, Yao, Humphrey H-C, Johnson, Kamin J

“…Fetal testis steroidogenesis plays an important role in the reproductive development of the male fetus. While regulators of certain aspects of steroidogenesis…”
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In vivo analysis of progesterone receptor action in the uterus during embryo implantation by Franco, Heather L., Jeong, Jae-Wook, Tsai, Sophia Y., Lydon, John P., DeMayo, Francesco J.

“…In order for a successful pregnancy to occur, the embryo must attach to the luminal epithelial cells and invade into the stroma. Then, the surrounding stromal…”
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ERBB Receptor Feedback Inhibitor 1 Regulation of Estrogen Receptor Activity Is Critical for Uterine Implantation in Mice1 by Kim, Tae Hoon, Lee, Dong-Kee, Franco, Heather L, Lydon, John P, Jeong, Jae-Wook

“…Normal endometrial function requires a balance of progesterone (P4) and estrogen (E2) effects. E2 acts to stimulate the proliferation of uterine epithelial…”
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Ablation of Indian Hedgehog in the Murine Uterus Results in Decreased Cell Cycle Progression, Aberrant Epidermal Growth Factor Signaling, and Increased Estrogen Signaling1 by Franco, Heather L, Lee, Kevin Y, Broaddus, Russell R, White, Lisa D, Lanske, Beate, Lydon, John P, Jeong, Jae-Wook, DeMayo, Francesco J

“…Conditional ablation of Indian hedgehog (Ihh) in the murine uterus results in mice that are sterile because of defects in embryo implantation. We performed…”
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Constitutive Activation of Smoothened Leads to Female Infertility and Altered Uterine Differentiation in the Mouse1 by Franco, Heather L, Lee, Kevin Y, Rubel, Cory A, Creighton, Chad J, White, Lisa D, Broaddus, Russell R, Lewis, Michael T, Lydon, John P, Jeong, Jae-Wook, DeMayo, Francesco J

“…Previous work has identified Indian hedgehog (Ihh) as a major mediator of progesterone signaling during embryo implantation. Ihh acts through its downstream…”
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Granulosa Cell-Expressed BMPR1A and BMPR1B Have Unique Functions in Regulating Fertility but Act Redundantly to Suppress Ovarian Tumor Development by Edson, Mark A, Nalam, Roopa L, Clementi, Caterina, Franco, Heather L, DeMayo, Francesco J, Lyons, Karen M, Pangas, Stephanie A, Matzuk, Martin M

“…Bone morphogenetic proteins (BMPs) have diverse roles in development and reproduction. Although several BMPs are produced by oocytes, thecal cells, and…”
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Sex and hedgehog: roles of genes in the hedgehog signaling pathway in mammalian sexual differentiation by Franco, Heather L, Yao, Humphrey H.-C

“…The chromosome status of the mammalian embryo initiates a multistage process of sexual development in which the bipotential reproductive system establishes…”
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FZD1 Regulates Cumulus Expansion Genes and Is Required for Normal Female Fertility in Mice by LAPOINTE, Evelyne, BOYER, Alexandre, RICO, Charlène, PAQUET, Marilène, FRANCO, Heather L, GOSSEN, Jan, DEMAYO, Francesco J, RICHARDS, Joanne S, BOERBOOM, Derek

“…WNT4 is required for normal ovarian follicle development and female fertility in mice, but how its signal is transduced remains unknown. Fzd1 encodes a WNT…”
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Ablation of Indian Hedgehog in the Murine Uterus Results in Decreased Cell Cycle Progression, Aberrant Epidermal Growth Factor Signaling, and Increased Estrogen Signaling by Franco, Heather L, Lee, Kevin Y, Broaddus, Russell R, White, Lisa D, Lanske, Beate, Lydon, John P, Jeong, Jae-Wook, DeMayo, Francesco J

“…Conditional ablation of Indian hedgehog (Ihh) in the murine uterus results in mice that are sterile because of defects in embryo implantation. We performed…”
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ERBB Receptor Feedback Inhibitor 1 Regulation of Estrogen Receptor Activity Is Critical for Uterine Implantation in Mice by Kim, Tae Hoon, Lee, Dong-Kee, Franco, Heather L, Lydon, John P, Jeong, Jae-Wook

“…Normal endometrial function requires a balance of progesterone (P4) and estrogen (E2) effects. E2 acts to stimulate the proliferation of uterine epithelial…”
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GATA2 is expressed at critical times in the mouse uterus during pregnancy by Rubel, Cory A., Franco, Heather L., Jeong, Jae-Wook, Lydon, John P., DeMayo, Francesco J.

“…► We confirm GATA2 as a P4 responsive target in the uterus. ► We examined GATA2 protein expression during early pregnancy and decidualization. ► GATA2 peak…”
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Constitutive Activation of Smoothened Leads to Female Infertility and Altered Uterine Differentiation in the Mouse by FRANCO, Heather L, LEE, Kevin Y, RUBEL, Cory A, CREIGHTON, Chad J, WHITE, Lisa D, BROADDUS, Russell R, LEWIS, Michael T, LYDON, John P, JEONG, Jae-Wook, DEMAYO, Francesco J

“…Previous work has identified Indian hedgehog (Ihh) as a major mediator of progesterone signaling during embryo implantation. Ihh acts through its downstream…”
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A Role for Site-Specific Phosphorylation of Mouse Progesterone Receptor at Serine 191 in Vivo by Grimm, Sandra L, Ward, Robert D, Obr, Alison E, Franco, Heather L, Fernandez-Valdivia, Rodrigo, Kim, Jung-Sun, Roberts, Justin M, Jeong, Jae-Wook, DeMayo, Francesco J, Lydon, John P, Edwards, Dean P, Weigel, Nancy L

“…Progesterone receptors (PRs) are phosphorylated on multiple sites, and a variety of roles for phosphorylation have been suggested by cell-based studies…”
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